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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
68 articles
Newest firstBackground Maturity-onset diabetes of the young (MODY) is a rare monogenic diabetes with significant renal risk, especially when combined with hyperglycemia, obesity, and other factors. While chronic cannabis use may further accelerate kidney decline, no previous reports have described rapid progression to ESRD in a young patient with MODY, obesity, hypertension, and cannabinoid hyperemesis, as presented here. Cas…
Open article record in new tab ↗Hypertensionis one of the leading causes of cardiovascular disease and premature death worldwide, affecting more than 1.2 billion adults, with a significant part living in low- and middle-income countries. Pediatric hypertension is also a growing concern, with an estimated 4.5% of children in the United States affected. The 2024 European Society of Cardiology guidelines provide updated protocols for diagnosing and…
Open article record in new tab ↗BACKGROUND: Hypertension (HTN) results from intricate molecular mechanisms, making clinical remission difficult to achieve. This study explores the molecular pathways through which cannabidiol (CBD) may influence HTN. METHODS: Several RNA sequencing datasets related to HTN were retrieved from the GEO database and divided into training and validation sets. Candidate genes potentially associated with HTN were screen…
Open article record in new tab ↗Background Hypertension is a leading risk factor for cardiovascular disease, particularly in ageing populations. While pharmacological interventions are common, issues with long-term adherence and side effects have prompted interest in alternative treatments. Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa, has been proposed as a potential agent for blood pressure regulation due to its anxiolyti…
Open article record in new tab ↗BackgroundHypertension remains one of the most challenging healthcare problems in the community. It is a common, measurable, and treatable condition that is nonetheless responsible for millions of preventable deaths each year. Hypertension affects approximately 1.28 billion adults worldwide, yet fewer than half (46%) are aware of their condition. Undiagnosed hypertension is a critical public health gap, contributi…
ObjectiveTo determine the absolute risk of starting dialysis versus mortality among adults with chronic kidney disease (CKD) treated at EsSalud from 2013 to 2022, utilizing data from the Renal Health Surveillance system (VISARE). MethodsThis retrospective cohort study analyzed clinical records from the VISARE system (EsSalud). We estimated rates of dialysis initiation and death using Fine & Gray competitive risk m…
BackgroundNon-communicable diseases (NCDs) are significant public health concerns in Bangladesh, placing a heavy burden on the healthcare system. While the situation before COVID-19 was well-documented, it is unclear how the pandemic has impacted the prevalence and risk factors of these diseases. This study provides the first comparative assessment of the prevalence and determinants of diabetes mellitus (DM) and h…
Open article record in new tab ↗Background and ObjectiveBlood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent on clinician experience. Treatment choices can be personalised by patient empowerment, metabolomic profiles and augmented by machine learning, but robust evaluation is lacking on how these can be combined to enhance clinical effectiveness. The HYPERMARKER trial will eva…
BackgroundThe coexistence of cancer and hypertension presents complex clinical challenges, yet limited research has characterized this population using nationally representative data. Understanding demographic patterns, social determinants of health, and environmental health perceptions in this group is essential for developing targeted interventions. MethodsWe analyzed data from the Health Information National Tr…
Open article record in new tab ↗Background Pharmacists can play a crucial role in delivering the holistic care model. Research suggests that HIV-positive African American patients particularly benefit from this approach compared to other communities. Typically, pharmacists in community pharmacy settings are limited in their access to a patient's medical record, preventing holistic care delivery. Objectives This study addressed the impact of acce…
Open article record in new tab ↗Backgrounds Cannabigerol (CBG) is a non-psychoactive phytocannabinoid with a broad spectrum of biological effects. However, there is still too little research on its safety especially its effects on the cardiovascular system. Due to its agonist effects on alpha-2-adrenergic receptors (α2AR), it is speculated that it may have applications in the pharmacotherapy of metabolic syndrome, particularly hypertension. Thus…
Open article record in new tab ↗Hemp (Cannabis sativa L.) leaf oil (HLO) contains several bioactive compounds such as phenolics, flavonoids, and quercetin. However, the effects of HLO on hypertensive conditions have not yet been investigated. This study investigated the cardiovascular protective effects of HLO in a nitric oxide (NO) synthase inhibitor-induced hypertensive rat model. Five weeks of HLO administration significantly prevented blood…
Our study investigated the link between blood pressure control and the Social Determinants of Health of 142 adult hypertensive patients, treated at Muranga County Referral Hospital, Kenya, during November 2023 while receiving blood pressure interventions. Blood pressure readings were obtained from hospital records. A systematic random sampling technique was used for recruiting participants. Quantitative data was c…
ObjectiveNurses face various occupational stressors that are associated with an increased risk of hypertension. This study aimed to determine the prevalence of hypertension and its associated factors among nurses in private and public tertiary hospitals in Dar es Salaam, Tanzania. MethodsA cross-sectional study was conducted between July to August 2023, among nurses from one private and one public tertiary hospita…
Open article record in new tab ↗BackgroundThe universal test-and-treat (T&T) policy has improved HIV outcomes but may influence hypertension (HTN) risk due to prolonged antiretroviral therapy (ART) exposure. We compared HTN prevalence and risk factors among PLHIV before and after T&T implementation in Zambia. MethodsA retrospective cohort study analyzed 6,409 PLHIV (2,920 pre-T&T and 3,489 post-T&T) from 12 Southern Province districts. Data on d…
BackgroundAortic aneurysm (AA) is a life-threatening disease with significant global burden. ObjectivesThis study aims to evaluate epidemiological trends and risk factors for AA-related mortality from 1990 to 2021 across regions, accounting for age, sex, and socio-economic factors. MethodsUsing Global Burden of Disease (GBD) Study 2021, we analyzed AA-related death, death rates, and the age-standardized AA-related…
Attributed to poverty and resource constraint situations, the population in low- and middle-income sub-Saharan countries like Lesotho is at high risk of preventable non-communicable diseases such as hypertension. Literature showed a high burden of hypertension in sub-Saharan Africa. However, no study assessed the burden of hypertension and the situation of treatment-seeking among the household population of Lesoth…
Open article record in new tab ↗BackgroundThe World Health Organization (WHO) non-laboratory cardiovascular disease (CVD) risk chart is sub-region-specific and is advocated in resource-constrained settings. However, the extent of agreement with laboratory-based assessment among hypertensive adults attending primary health centers (PHCs) in the West Africa sub-region remains unknown. This study compared 10-year CVD risk among adults with hyperten…
Open article record in new tab ↗Background Observational evidence investigating associations between cannabis use and blood pressure and hypertension is inconsistent. Methods Cross-sectional data from 3,255 participants at Exam 6 (2016-2018) of the Multi-Ethnic Study of Atherosclerosis (MESA) were analyzed, including self-reported cannabis smoking patterns, standardized measures of systolic blood pressure (SBP), diastolic blood pressure (DBP), p…
Open article record in new tab ↗Patients with psychotic disorders exhibit elevated mortality and morbidity rates compared to the general population primarily due to comorbid somatic diseases. This study aims to describe the prevalence of selected risk factors and somatic disorders among psychiatric patients with a diagnosis of psychotic disorder. Material and methods: Data were retrieved from Greenland's nationwide electronic medical record. The…