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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
48 articles
Newest firstMedication adherence among patients with diabetes remains suboptimal in low- and middle-income countries, including Nigeria. Emerging digital health interventions such as AI-powered virtual support may be associated with improved adherence behaviours. This study examined self-care competence and perceived AI-powered virtual support as predictors of medication adherence among patients with diabetes. A cross-section…
Open article record in new tab ↗Background Pharmacists can play a crucial role in delivering the holistic care model. Research suggests that HIV-positive African American patients particularly benefit from this approach compared to other communities. Typically, pharmacists in community pharmacy settings are limited in their access to a patient's medical record, preventing holistic care delivery. Objectives This study addressed the impact of acce…
Open article record in new tab ↗Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are commonly prescribed for the management of type 2 diabetes mellitus (T2DM). However, the potential connection between GLP-1 RAs and the risk of pancreatitis presents a complex and nuanced issue. Although these drugs are effective in improving blood sugar control and cardiovascular health, their association with pancreatitis remains an area of c…
Open article record in new tab ↗BackgroundTo quantify the economic burden and health-related quality of life (HRQoL) impact of heart failure (HF) in the U.S., stratified by age and diabetes status. MethodsUsing a micro-level, bottom-up prevalence-based approach from a payer perspective, we analyzed healthcare costs from the Optum Research Database (ORD). HF prevalence and HRQoL via EuroQol 5-Dimensions and Healthy Days instruments were estimated…
Open article record in new tab ↗BackgroundDiabetic kidney disease (DKD) is a chronic complication of diabetes mellitus (DM). DKD and chronic kidney disease (CKD) are both long-term conditions requiring ongoing patient care. Individuals living with DKD or CKD can benefit from mobile apps that support effective self-management. However, limited evidence is available about what mobile apps features are commonly included for DKD. ObjectiveThis scopi…
Open article record in new tab ↗BackgroundTuberculosis (TB) is a significant global health threat, particularly in high-burden countries like Pakistan. The incidence of diabetes mellitus among TB patients is rising, necessitating integrated clinical management to address the dual burden. Despite existing guidelines, the implementation of integrated TB diabetes care remains inadequate in Pakistan. This study aims to explore the implementation det…
Open article record in new tab ↗The global nutritional transition has led to the increased frequency and severity of chronic degenerative diseases worldwide, primarily driven by chronic inflammatory stress. At mealtimes, various pharmaceutical products aim to prevent such inflammatory stress, but they usually cause various systemic side effects. Therefore, the supplementation of natural and safe ingredients is a promising strategy to reduce the…
Open article record in new tab ↗Introduction Diabetes mellitus (DM) is a common endocrinopathy in felines. Treatment is based on glycemic control and management of clinical signs by insulin administration coupled with a low-carbohydrate and high-protein content diet. However, achieving adequate remission or glycemia control is not always possible. Effects of cannabinoids on the regulation of glucose uptake and the incidence of diabetes have been…
Open article record in new tab ↗Dipeptidyl peptidase-IV (DPPIV) inhibitory peptides are a class of antihyperglycemic drugs used in the treatment of type 2 diabetes mellitus, a metabolic disorder resulting from reduced levels of the incretin hormone GLP-1. Given that DPPIV degrades incretin, a key regulator of blood sugar levels, various antidiabetic medications that inhibit DPPIV, such as vildagliptin, sitagliptin, and linagliptin, are employed.…
BackgroundChronic Kidney Disease (CKD) is a significant complication in people with diabetes, leading to serious adverse health outcomes and increased healthcare costs globally individually and on healthcare systems. This problem become more complicated when it is in Low and middle in countries including Rwanda when access to early diagnostic services is limited. Early prediction and intervention can improve patie…
Open article record in new tab ↗BackgroundA growing number of people living with HIV (PLHIV) also have non-communicable diseases (NCDs). Shifting the health systems paradigm from vertical, parallel care to an integrated delivery model may facilitate better care-seeking and ultimately improve outcomes for people with a dual burden of HIV and NCDs. We describe the current state of integration of hypertension and diabetes care into HIV treatment in…
Obesity is associated with a cluster of metabolic disorders, chronic low-grade inflammation, altered gut microbiota, increased intestinal permeability, and alterations of the lipid mediators of the expanded endocannabinoid (eCB) signaling system, or endocannabinoidome (eCBome). In the present study, we characterized the profile of the eCBome and related oxylipins in the small and large intestines of genetically ob…
Metabolic syndrome is a complex disease state, which appears mostly as a consequence of an unhealthy, sedentary lifestyle. Metabolic complications include insulin resistance (IR), diabetes, dyslipidemia, hypertension, and atherosclerosis, impairing life standards and reducing life expectancy. The endocannabinoid system (ECS) has an important role in signalization processes, not only in the central nervous system,…
Open article record in new tab ↗Objective This study assessed the efficacy of INV-202, a novel peripherally restricted cannabinoid type-1 receptor (CB1R) inverse agonist, in a streptozotocin-induced type-1 diabetes nephropathy mouse model. Methods Diabetes was induced in 8-week-old C57BL6/J male mice via intraperitoneal injection of streptozotocin (45 mg/kg/day for 5 days); nondiabetic controls received citrate buffer. Diabetic mice were randomi…
The following review focuses on the scientific studies related to the role of endocannabinoid system (ECS) in pancreatic islet physiology and dysfunction. Different natural or synthetic agonists and antagonists have been suggested as an alternative treatment for diabetes, obesity and metabolic syndrome. Therapeutic use of Cannabis led to the discovery and characterization of the ECS, a signaling complex involved i…
Open article record in new tab ↗Introduction Polybrominated diphenyl ethers (PBDEs) are commercially used flame retardants that bioaccumulate in human tissues, including breast milk. PBDEs produce endocrine and metabolic disruption in experimental animals and have been associated with diabetes and metabolic syndrome (MetS) in humans, however, their sex-specific diabetogenic effects are not completely understood. Our past works show glucolipid dy…
The pharmacological potential of industrial hemp (Cannabis sativa) has been widely studied. However, the majority of studies have focused on cannabidiol, isolated from the inflorescence and leaf of the plant. In the present study, we evaluated the anti-diabetic potential of hemp root water (HWE) and ethanol extracts (HEE) in streptozotocin (STZ)-induced insulin-deficient diabetic mice. The administration of HWE an…
Open article record in new tab ↗Obesity and nonalcoholic fatty liver disease (NAFLD) constitute global and growing epidemics that result in therapeutic dead ends. There is an urgent need for new and accessible treatments to improve and widen both preventive and curative approaches against NAFLD. The endocannabinoid system (ECS) is recognized as a complex signaling apparatus closely related to metabolic disorders and is a key target for treating…
Open article record in new tab ↗The incidence of type 2 diabetes (T2D) is rising, and finding new treatments is important. C. sativa is a plant suggested as a potential treatment for T2D, but how it works needs to be clarified. This study explored the pharmacological mechanism of C. sativa in treating T2D. We identified the active compounds in C. sativa and their targets. From there, we examined the genes associated with T2D and found overlappin…
Open article record in new tab ↗Diabetes is a prevalent chronic condition that poses significant challenges to early diagnosis and identifying at-risk individuals. Machine learning plays a crucial role in diabetes detection by leveraging its ability to process large volumes of data and identify complex patterns. However, imbalanced data, where the number of diabetic cases is substantially smaller than non-diabetic cases, complicates the identifi…
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