Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
402 articles
Newest firstBackground Patients with inflammatory bowel disease (IBD) increasingly use cannabis. Studies investigating the effectiveness and safety of cannabis as a therapeutic option for IBD have reported conflicting findings, and recent reviews have not incorporated evidence from real-world studies. This systematic review assessed controlled non-interventional studies and interventional trials evaluating the effectiveness o…
Open article record in new tab ↗The objective of this study was to explore non-aqueous spray-freeze-drying (SFD) as a formulation strategy to stabilize and improve the dissolution of Cannabis sativa full extracts. The medicinal use of Cannabis sativa has strongly intensified over the last decade. Here, Cannabis flos full extracts prepared by tert-butanolic solutions with 25% solid content were directly processed via spray-freeze-drying (SFD) wit…
Open article record in new tab ↗Background (-)-Cannabidiol (CBD) is a naturally occurring terpenoid belonging to the cannabinoid family, which is isolated from the Cannabis sativa L. plant. It possesses significant therapeutic potential, providing minimal side effects and no psychoactive activity. However, CBD applications are limited by a poor aqueous solubility and low bioavailability. Objective To address these limitations and investigate the…
Open article record in new tab ↗Background Although current treatment guidelines recommend against cannabinoids for Post-Traumatic Stress Disorder (PTSD), their use has increased in clinical settings despite fragmented evidence. This review critically examines the efficacy, effectiveness, and safety of cannabinoid-based interventions for PTSD. Methods We conducted a scoping review following PRISMA-ScR guidelines. Five databases were searched up…
Open article record in new tab ↗BackgroundFollowing the recent amendments in international legislations on cannabis, semi-synthetic cannabinoid derivatives have become increasingly available worldwide. These new psychoactive substances are obtained through chemical modifications of cannabidiol (CBD), a widely available legal compound, or through chemical synthesis from fitting precursors. Compared to Δ9-tetrahydrocannabinol (Δ9-THC), the primary…
BACKGROUND: Following the legalization of recreational cannabis in Canada under the Cannabis Act (2018), regulatory frameworks were implemented to ensure product safety, quality, and consistency within the legal market. Previous studies revealed significantly greater pesticide contamination in illegal cannabis than in legal products. In light of these findings, the present study expands contaminant surveillance to…
Open article record in new tab ↗BACKGROUND: With expanding U.S. cannabis legalization, clarifying its health impacts is critical. This study explores the association between cannabis use frequency and serum Klotho—a biomarker of aging and metabolic health. METHODS: We analyzed 5,827 adults aged 40–59 years from National Health and Nutrition Examination Survey (NHANES) 2007–2016. Cannabis use was self-reported by Computer Assisted Self Interview…
Open article record in new tab ↗BACKGROUND: Pain is one of the leading causes of disability worldwide. Despite the various pharmacological treatments available, patients with chronic pain often remain with significant disabilities and unsatisfactory pain control. Cannabis and cannabinoids are sometimes used in the treatment of chronic pain as they have been shown to be useful in a subset of patients. Some of the adverse effects associated with c…
Open article record in new tab ↗Background Micropropagation is an increasingly sought-after propagation method in the cannabis industry as growers seek to maximize production efficiency, improve multiplication rates and cultivate plants that are free from biotic stress. However, knowledge about the impact of micropropagation on cannabis is still limited in the scientific literature, as most studies have primarily focused on optimizing environmen…
BACKGROUND: The cannabis plant produces many bioactive compounds, including the major cannabinoids THC and CBD, and many lesser studied “minor” phytocannabinoids including cannabinol (CBN), cannabichromene (CBC), cannabicyclol (CBL), and cannabigerol (CBG). These compounds are touted for various ailments, including pain, inflammation, and anxiety, but experimental data on their effects are lacking, especially that…
Open article record in new tab ↗Background Although prior research has examined how cannabis legal status relates to psychosocial predictors of use, less is known about whether recreational legalization influences public knowledge of specific cannabis-related health effects. This study addresses this gap by analyzing trends in knowledge of health effects of cannabis consumption following the legalization of recreational cannabis in Canada. Metho…
Open article record in new tab ↗Introduction Following marijuana legalization in several U.S. states, motivations for its use have expanded, especially among marginalized populations. While prior research links marijuana use with disordered eating, little is known about this relationship within sexual minority groups, who are already at elevated risk for body dissatisfaction and unhealthy weight control behaviors. This study examines association…
Open article record in new tab ↗BACKGROUND: Cannabis sativa L. is increasingly used for medicinal and commercial purposes, yet most reviews treat chemical composition, ecology, and post-harvest processing as separate topics. This manuscript advances a conceptual framework that links chemical stability, chemodiversity, and post-harvest quality across the production chain (“crop to shop”), emphasizing and detailing how environmental and technologi…
The rapid growth of the cannabidiol (CBD) market has raised concerns about product labeling accuracy and quality control. This study aimed to validate a high-performance thin-layer chromatography (HPTLC) method and apply it to analyze CBD content in commercial oils and e-liquids available in Costa Rica. The HPTLC method was validated following guidelines of the International Council for Harmonization of Technical…
Open article record in new tab ↗BACKGROUND: In October 2018, Canada legalized non-medical cannabis, increasing accessibility nationwide. Although a separate medical cannabis framework exists, many individuals with cancer may now obtain cannabis through non-medical channels rather than through the medical system. This shift raises questions about how legalization has influenced patients’ attitudes and preferences regarding the use of cannabis to…
Open article record in new tab ↗BackgroundMedical cannabis has gained increasing attention globally for its potential in treating various conditions. As the use of medical cannabis expands, it is crucial for future healthcare professionals, particularly physicians, to have a comprehensive understanding of its clinical applications, side effects, and legal status. Therefore, this study aimed to assess the knowledge and attitudes of healthcare stu…
Open article record in new tab ↗Background Opioid withdrawal is a significant challenge for people seeking to reduce or eliminate opioid use, and unmanaged withdrawal increases the risk of relapse and overdose. Using cannabis to manage opioid withdrawal has been reported by people who use opioids, yet it is not clear whether this leads to reductions in opioid use. Moreover, because pain is prevalent among people who use unregulated opioids (PWUO…
Open article record in new tab ↗Background Gender identity influences patterns of substance use; however, few population-level studies have included transgender and gender-diverse identities when examining patterns of cannabis use by gender identity. Methods Data are from the International Cannabis Policy Study's national, repeat cross-sectional surveys conducted annually between 2018-2023 in Canada and the United States. Weighted logistic and l…
Open article record in new tab ↗BACKGROUND: Consumption of Cannabis sativa (CS), a well known psychoactive substance may impose threat on the hormonal activities of the body, hence, a protective measure is needed to prevent this threat. This study investigates the effects of melatonin and CS together with its receptors (cannabinoid receptors 1 and 2) on hormonal toxicity in female rats. METHODS: Fifty female rats were assigned into ten groups of…
Open article record in new tab ↗Since federal legalisation in November 2016, Australia’s medical cannabis regulation has evolved into a complex framework that involves the Therapeutic Goods Administration, state health departments, and multiple professional oversight bodies. This narrative review examines the policy hurdles and coordination gaps that have emerged between 2016 and 2024, providing a longitudinal perspective on the ongoing debate.…
Open article record in new tab ↗