Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
373 articles
Newest firstCannabidiol (CBD) has attracted growing scientific and clinical interest due to its potential therapeutic applications and increasing availability across Europe. This narrative review examined the regulatory status, market availability, and clinical use of CBD in Croatia in relation to selected European Union countries and international reference models (Canada and Australia). A literature search was conducted usi…
Open article record in new tab ↗Although random assignment is the standard for drawing causal inferences within clinical trials, it is generally precluded in legal market cannabis research given its federal classification as a schedule 1 drug. Unfortunately, this may cause selection bias and compromise internal validity, and thus, alternative approaches are necessary. One such approach in this context, as well as more broadly, is quasi-random as…
Open article record in new tab ↗Background (-)-Cannabidiol (CBD) is a naturally occurring terpenoid belonging to the cannabinoid family, which is isolated from the Cannabis sativa L. plant. It possesses significant therapeutic potential, providing minimal side effects and no psychoactive activity. However, CBD applications are limited by a poor aqueous solubility and low bioavailability. Objective To address these limitations and investigate the…
Open article record in new tab ↗Introduction Changes in regulatory policies regarding cannabis have led to a rapid expansion of the cannabis market and a substantial increase in cannabis sales. This study examined medicinal and recreational cannabis demand in a hypothetical legalisation scenario in Spain among people who use over-the-counter CBD, THC only and CBD + THC. Methods A cross-sectional study comprising 1492 participants aged 16-30. The…
Introduction and aim Assessment of antitumor activity in preclinical models remains challenging when relying solely on conventional size-based imaging, particularly for complex agents such as cannabinoids, whose biological effects may not translate into early volumetric tumor changes. Cannabinoid formulations, including the synthetic cannabinoid JWH-182, Cannabixir® Medium dried flowers, and Cannabixir® THC full e…
Open article record in new tab ↗IntroductionChanging trends in legal recreational cannabis markets necessitates the continuous monitoring of important market metrics such as price, potency, type, and availability of cannabis products which may influence consumer purchasing behavior. After initial legalization of recreational cannabis use in Canada in 2018 and expansion of the legal market in 2019, an increase in product types and decrease in pri…
Open article record in new tab ↗Background Medical cannabis is now commonly prescribed for a range of chronic health conditions. Many medical cannabis products contain delta-9-tetrahydrocannabinol (THC), the intoxicating component in cannabis, though it is unclear whether these products produce impairment when used as prescribed and at therapeutic doses. With current Australian laws prohibiting driving with any amount of THC in one's system, thi…
Open article record in new tab ↗Cannabidiol (CBD) is a bioactive phytocannabinoid with considerable pharmacological potential. However, its limited aqueous solubility and high lipophilicity remain significant barriers to its broader pharmaceutical application. In this study, the enzymatic potential of selected filamentous fungi was investigated as a whole-cell biocatalytic platform for the regioselective functionalization of CBD. Sixteen fungal…
Open article record in new tab ↗This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2-q13.1 duplication or deletion syndromes (15q-DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5 (10-22.5) years, with a median (IQR) follow-up of 21 (14-33) months. Al…
INTRODUCTION: This study investigated the effects of a topical cannabidiol (CBD) gel compared to placebo on muscle function recovery, perceived muscle soreness, and blood marker of muscle damage following strenuous exercise designed to induce muscle damage. METHODS: Fifteen physically active students (age: 21.4 ± 2.1 years; mass: 78.0 ± 9.5 kg; height: 181.7 ± 5.0 cm) participated in the study. To induce muscle da…
Open article record in new tab ↗IntroductionApproximately 20% of cancer patients report cannabis use, yet only 30% of oncologists feel sufficiently informed to make recommendations on its use. This study aimed to visualize the network of themes that arise within cancer patients’ reported experiences with cannabis.Materials and methodsData was collected via an online survey of 65 patients who self-reported the use of cannabis in their treatment f…
Open article record in new tab ↗Background Cannabinoids have attracted significant attention for their potential therapeutic application in cancer research. However, recent studies have reported antitumor activity of cannabidiolic acid (CBDA)-the acidic precursor of CBD-in breast cancer cells, involving modulation of cyclooxygenase signaling. To our knowledge, no investigations have examined the effects of CBDA on RNA expression and signaling pa…
BACKGROUND: It is well-established that cannabis can affect driving in the hours after cannabis use, but the exact duration of these effects, and relationship with delta-9-tetrahydrocannabinol (THC) concentrations in blood and oral fluid, remains to be determined. METHODS: Frequent (≥ 4 times a week) users of smoked cannabis drove a simulator the morning after (12-15 hours) last use of smoked cannabis; a control g…
Open article record in new tab ↗Cury et al. present the first randomized placebo-controlled trial of a low-dose balanced tetrahydrocannabinol–cannabidiol extract targeting cognition in Alzheimer’s disease (AD). The study marks a milestone in a field long dominated by anecdotes and low-certainty evidence. While it demonstrated modest cognitive improvement on the Mini-Mental State Examination, the lack of functional and behavioral outcomes raises…
Open article record in new tab ↗Background/Objectives: Current literature regarding the efficacy of cannabis to reduce chronic pain intensity is mixed. Despite growing accessibility throughout the U.S., it is still unclear if the naturalistic use of recreational cannabis edible products is associated with decreases in pain intensity on days of use or longitudinally, and if these associations are dependent on the doses of delta-9-tetrahydrocannab…
Open article record in new tab ↗This retrospective cohort study evaluated the tolerability, efficacy, and safety of adjunctive cannabidiol (CBD) therapy in pediatric-onset intractable epilepsy across diverse genetic and nongenetic etiologies. Twenty-nine patients aged 6 to 24 years, treated at Korea University Hospitals between April 2019 and May 2024, were included. The median follow-up duration was 14.3 months. Confirmed genetic etiologies inc…
Open article record in new tab ↗Aims Cannabidiol (CBD), the main non-intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP-mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol, two commonly used analgesics. Methods This was an open-label, fixed-seque…
Background Cannabidiol (CBD) is one of over 100 naturally occurring phytocannabinoids in Cannabis. While extensive research has evaluated the effects that CBD and other phytocannabinoids have on consumers, less attention has been directed towards studying the health impacts of the compounds formed when cannabinoids are burned. Such an investigation is highly desirable, as smoking remains the most common form of Ca…
Open article record in new tab ↗Introduction Cannabidiol (CBD) use has increased substantially in the United States alongside expanding legalization of cannabis and hemp-derived products. CBD is widely marketed for recovery, sleep, stress reduction, and overall well-being, yet evidence supporting these claims in healthy, physically active populations remains limited and mixed. Most controlled trials have been conducted in predominantly male coho…
Open article record in new tab ↗Background Sarcoids are locally invasive skin tumors in equids, associated with bovine papillomavirus. Hypothesis/objectives Address potential applications of cannabidiol (CBD) in veterinary medicine. We evaluated the response of equine sarcoid cells to CBD in vitro, focusing on viability, invasiveness, and matrix remodeling. Animals Three primary sarcoid cell lines. Methods Cells were treated with CBD (20, 6.75,…
Open article record in new tab ↗