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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
36 articles
Newest firstBackgroundHypertension remains one of the most challenging healthcare problems in the community. It is a common, measurable, and treatable condition that is nonetheless responsible for millions of preventable deaths each year. Hypertension affects approximately 1.28 billion adults worldwide, yet fewer than half (46%) are aware of their condition. Undiagnosed hypertension is a critical public health gap, contributi…
Open article record in new tab ↗ObjectiveCognitive impairment is common among older adults with epilepsy, although efficient screening tools suitable for routine use are lacking. Here we examine, for the first time, the utility of the Alzheimers Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) as a screening tool to identify cognitive impairment in older adults with epilepsy. MethodsParticipants included 83 adults (ages [≥] 55) with epilep…
Open article record in new tab ↗IntroductionPersistent infection with high-risk Human Papillomavirus (hr-HPV) in women is a leading cause of cervical cancer, and its co-infection among people living with HIV (PLHIV) increases the risk of HPV-associated cancer, including oropharyngeal and anogenital cancers. In sub-Saharan Africa, awareness of HPV is limited, screening and vaccine adoption are critically low, undermining efforts toward sexually t…
Open article record in new tab ↗ObjectiveThis study is to evaluate the cost-effectiveness of an annual screening program for diabetic retinopathy (DR) at primary healthcare level among patients with type 2 diabetes mellitus (type 2 DM) from a societal perspective in Danang city, Vietnam. MethodsA Markov model was developed to compare costs and effects of an annual screening program for DR using non-mydriatic fundus photography with the absence o…
Open article record in new tab ↗Purpose Intraocular pressure (IOP) is a major clinical marker used to diagnose glaucoma and monitor its treatment. Marijuana use can confound IOP measurements by temporarily lowering the IOP, potentially leading to missed diagnoses of glaucoma or a false sense of effective treatment. Therefore, factors that may affect diagnosis or treatment of glaucoma need to be characterized and considered. We aim to assess the…
Open article record in new tab ↗This paper introduces the special issue on cannabis use in Europe. It describes data on the prevalence of cannabis use in Europe and the more limited data on the prevalence of cannabis use disorders, one of the most common forms of drug problem treated in many countries in Europe. It summarises what research has indicated about the adverse effects of acute and chronic cannabis use and discusses potential health sy…
Open article record in new tab ↗Monoacylglycerol lipase (MAGL) degrades the endocannabinoid 2-arachidonyl glycerol. MAGL inhibitors, such as the triterpene pristimerin, alleviate neuropathic pain in animal models. In silico studies were carried out using SwissDock, PyRx-0.8 and CB-Dock2, to check if they correlated with the in vitro MAGL inhibition potency of various triterpenes. In terms of affinity, free energy of binding and docking scores to…
Open article record in new tab ↗Background Substance use among adolescents is strongly associated with adverse physical, mental health, and social outcomes. Prevention and early intervention can reduce the likelihood of future problems, but requires valid and reliable screening tools capable of assessing risk across a range of substances. This study assessed the validity, reliability, and clinical utility of the Alcohol, Smoking and Substance In…
Background The post-Soviet country of Georgia has recently decriminalized recreational cannabis use, yet implementation of screening for cannabis use in clinical practice remains unclear. This study assesses relevant knowledge, attitudes, and practices of primary health care physicians (PCPs) regarding recreational cannabis use in the country of Georgia. Methods We conducted a mixed-method study, starting with a c…
The Cannabis Use Disorders Identification Test-Revised (CUDIT-R) is an eight-item screening tool designed to identify problematic cannabis use. The present study intended to assess the psychometric properties of the measure in a youth sample. N = 76 participants completed the CUDIT-R and a measure of cannabis consumption. All participants underwent an assessment for a current cannabis use disorder using the Struct…
Open article record in new tab ↗BackgroundArtificial intelligence (AI) applied to routine electrocardiograms (ECGs) offers promise for screening of structural heart disease (SHD), yet broad clinical integration remains limited by high false positive rates and the lack of tailored deployment strategies. MethodsWe developed TARGET-AI, a multimodal AI-enabled pipeline that integrates longitudinal electronic health record (EHR) data with ECG images…
BackgroundCandida auris is an emerging fungal pathogen that is often multidrug-resistant. It can persist on skin and in hospital environments, leading to outbreaks and severe infections for patients at risk. Several countries and institutions are working on establishing guidelines and recommendations for prevention. This review aims to assess the evidence on factors associated with C. auris colonisation or infecti…
This study examines changes in oral risk habits and identifies factors influencing these changes among participants in a population-based oral cancer screening program to support effective public health interventions. The study included 2,569,920 individuals aged 30 and older who participated in Taiwans Oral Cancer Screening Program at least twice between 2010 and 2021. Changes in cigarette smoking and betel quid…
Open article record in new tab ↗Background Clinical practice guidelines (CPGs) synthesize high-quality information to support evidence-based clinical practice. In primary care, numerous CPGs must be integrated to address the needs of patients with multiple risks and conditions. The BETTER program aims to improve prevention and screening for cancer and chronic disease in primary care by synthesizing CPGs into integrated, actionable recommendation…
BACKGROUND AND AIMS: Poor substance use-related health outcomes after release from prison are common. Identifying people at greatest risk of substance use and related harms post-release would help to target support at those most in need. The Alcohol Smoking and Substance Involvement Screening Test (ASSIST) is a validated substance use screener, but its utility in predicting substance-related hospitalisation post-r…
Introduction Cannabis use and misuse are surging among the Chinese community in East and Southeast Asia. A quick screening instrument that can effectively identify users with dependence for early intervention is in utmost need. This study examined the psychometric properties of the Chinese version of the Severity of Dependence Scale for cannabis (C-SDS-C) in screening for the DSM-5 defined Cannabis Use Disorder (C…
Open article record in new tab ↗ObjectiveTo compile the available literature regarding the usefulness, methodology used, and limitations of ACEs screening in a pediatric clinical sample, to prevent adverse health outcomes. IntroductionSeveral studies have found an association between the presence of adverse childhood experiences (ACEs) and the development of negative health outcomes, however the usefulness of screening for this condition and how…
Open article record in new tab ↗BackgroundDepression and anxiety are significant health burdens that greatly impact the quality of life of refugees and migrants. In this study, we have translated and culturally adapted the Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Screener (GAD-7) into Kinyarwanda and performed a validation study in a United States (US) primary care setting. MethodsA committee of experts translated an…
Cervical cancer screening has reduced cervical cancer-related mortality by over 70% in countries that have achieved high coverage. However, there are significant geographic disparities in access to screening. In Ghana, although cervical cancer is the second most common cancer in women, there is no national-level cervical cancer screening program, and only 2 to 4% of eligible Ghanaian women have ever been screened…
Background and aims Illicit substance use is common among people entering prisons, as is returning to substance use after release from prison. We aimed to assess the predictive validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) for returning to substance use after release from prison. Design A longitudinal design with baseline survey conducted between 2008 and 2010 in the 6 weeks be…