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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
14,906 articles
Newest firstBackground Pancreaticobiliary maljunction (PBM) is a congenital disease in which the pancreatic and bile ducts fuse outside the duodenal wall. Congenital biliary dilatation (CBD) involves PBM and dilatation of the extrahepatic bile duct. The lack of Oddi sphincter action at the confluence results in the retrograde flow of pancreatic juice into the bile duct, placing patients with CBD at high risk of biliary carcin…
Open article record in new tab ↗Hemp hurds (HHs), an underutilised lignocellulosic biomass (LB) from agricultural waste, offer potential for bioconversion into high-value bioproducts within a circular bioeconomy. Building on prior work involving magnetic nanoparticle-immobilised cellulase hydrolysis of pretreated HH, this study computationally designed candidate phaCAB expression constructs for cellulolytic hosts toward future polyhdroxybutyrate…
Open article record in new tab ↗Reliable and traceable quantification of cannabinoids is essential for forensic, regulatory, and quality control applications involving cannabis-derived products. However, the limited availability of certified reference materials (CRMs), particularly for minor cannabinoids such as cannabinol (CBN), remains a major analytical challenge. In this work, an integrated analytical and preparative strategy is presented fo…
Background Substance use among university students in Ghana is a pressing concern, with pronounced sex differences yet poorly characterised determinants. This study examined factors associated with lifetime alcohol, tobacco and cannabis use among undergraduate students, with explicit attention to sex-specific patterns. Methods A cross-sectional study was conducted from January to March 2023 at the University for D…
Open article record in new tab ↗Cannabis use can have detrimental effects on adolescents' mental health, often co-occurring with child and adolescent psychiatric disorders (CAPD). This study assessed diagnostic prevalence trends in cannabis-related disorders and co-occurring diagnosed CAPD in adolescents receiving outpatient treatment in Germany. Outpatient claims data from the national public health insurance system, covering almost 4 million c…
IntroductionCannabis use has been linked to alterations in cognitive control and emotional processing, although findings vary according to use pattern and abstinence status. This pilot study examined whether emotional interference is especially sensitive to short-term abstinence-related differences across cannabis-use profiles and whether such differences are accompanied by distinct prefrontal hemodynamic response…
Astrocytes play essential roles in brain function and disorders. Yet, compared to neurons, our knowledge of the physiological and pathological signaling mechanisms in astrocytes remains limited. As a major challenge, the ultrathin (~10-100 nm) processes of astrocytes render high-throughput quantitative molecular imaging within well-defined cellular contexts very difficult. Here, we introduce a single-molecule loca…
Open article record in new tab ↗Background and hypothesis A sex difference in the clinical presentation of schizophrenia is well known. Males have on average an earlier symptom onset, worse functional capacity, and more negative symptoms. Studies on the neurobiological correlates of psychosis show that brain endocannabinoid system (ECS) is dysregulated in male patients with first-episode psychosis (FEP). We now evaluated whether the brain ECS is…
IntroductionSubstance use is an important public health concern in Saudi Arabia. Coping strategies and perceived social support may be associated with substance-use patterns, but these relationships remain underexplored among individuals who report substance use in the Saudi context. This study aimed to examine substance-use patterns and their associations with coping dimensions, perceived social support, and sele…
Rimonabant (SR141716A), an inverse agonist of the cannabinoid receptor type 1 (CB1), once approved for treating obesity and metabolic disorders, was withdrawn shortly after due to psychiatric and psychological adverse events (PPAEs), including depression and suicidality. Although its primary pharmacological mechanism of action is well-characterized, the molecular basis underlying these neuropsychiatric effects rem…
Background CBD is widely studied for its stress-reduction and cognitive-enhancing properties, but its effects on hippocampal molecular organisation under physiological settings are unknown. Acute and long-term intraperitoneal CBD treatment at different doses was tested on hippocampus gene expression, circulating corticosterone, and behavioural performance in C57BL/6J mice. Results Short-term administration did not…
Open article record in new tab ↗N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) are lipid signalling molecules within the endocannabinoid system, which regulates numerous physiological processes and is implicated in diverse pathological conditions. Given the limited feasibility of obtaining human tissue samples, quantifying AEA and 2-AG in biological matrices is essential for understanding the endocannabinoid system in humans.…
Open article record in new tab ↗BackgroundCannabis use disorder affects a substantial proportion of the population and is often accompanied by mental health comorbidities, including depressive symptoms and problematic Internet use (PIU). This study explores the association between PIU and depressive symptoms among adults at high-risk of cannabis use disorder, a relationship insufficiently explored despite the high prevalence of these conditions…
Introduction Cannabidiol (CBD) has gained interest in equine medicine due to its potential therapeutic effects. Preclinical studies suggest that CBD may influence metabolic pathways relevant to metabolic syndrome, which present in both human and equine populations. The aim of this study was to evaluate the effects of oral CBD on metabolic parameters in Connemara ponies and to characterize its pharmacokinetics. Met…
Objective This study aimed to construct a high-efficiency dual-modal diagnostic model for treatment-resistant depression (TRD) by integrating serum metabolomics and clinical risk factors, and explore its metabolic pathological mechanisms. Methods A total of 93 major depressive disorder (MDD) patients (53 TRD, 40 non-TRD) were enrolled for a single-center retrospective study. Serum untargeted metabolomics and clini…
Open article record in new tab ↗Significance Flavor accessories (e.g., flavor capsules), which are separate products that can be used with combustible tobacco products to alter their flavor, are on the market. These new products may bypass flavor restrictions and appeal to youth, yet no research has examined US youth awareness or use of flavor accessories. This study aimed to examine awareness and use of flavor accessories among a sample of yout…
Objective The objective of this study was to examine whether cannabis exposure calls to the British Columbia Drug and Poison Information Centre (DPIC) were impacted by the legalization of non-medical cannabis in Canada. Methods We fit interrupted time series models to monthly counts of cannabis cases from 2013 to 2021, stratified by age and cannabis form. We set the intervention month to October 2018 legalization…
INTRODUCTION: In the Australian 2001-2013 National Drug Strategy Household Surveys (NDSHS), frequent cannabis use declined among higher socioeconomic groups while remaining stable among lower socioeconomic groups, suggesting a widening socio-demographic gap. This study examined trends in cannabis use frequency and sociodemographic disparities in Australia up to 2022/23. METHODS: Data were from eight waves of the N…
Open article record in new tab ↗This study examined the prevalence and patterns of polydrug use among a national sample of civilians aged 12 years or older, with a focus on polydrug use involving opioids, assessing the influence of the first drug used on these behaviors. Using 2020 National Survey on Drug Use and Health (NSDUH) data, five mutually exclusive drug groups were identified in a hierarchical order: opioid use, stimulant or psychoactiv…
Purpose This study used data from the National Health and Nutrition Examination Survey (NHANES) to examine associations between the use of four illicit drugs (cocaine, heroin, marijuana, and methamphetamine) and the dental caries experience among adults in the US using the Decayed, Missing and Filled Teeth (DMFT) index. Materials and methods Data from NHANES 2017-2018, a cross-sectional study that included adults…