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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
2,151 articles
Newest firstCannabidiol (CBD) has attracted growing scientific and clinical interest due to its potential therapeutic applications and increasing availability across Europe. This narrative review examined the regulatory status, market availability, and clinical use of CBD in Croatia in relation to selected European Union countries and international reference models (Canada and Australia). A literature search was conducted usi…
Open article record in new tab ↗Osteoporosis (OP) is a chronic metabolic disease characterized by reduced bone mass and impaired bone microstructure, posing a significant global health threat. Mitochondria, as the body's energy regulators, participate in numerous critical biological processes, and their dysfunction is a precipitating factor in various diseases. Accumulating evidence indicates that mitochondrial dysfunction-including abnormalitie…
Open article record in new tab ↗Cannabis-based therapies are widely used for chronic pain, yet their mechanisms and therapeutic windows remain incompletely defined. This review synthesizes preclinical and clinical evidence on how dose, route of administration, treatment duration, and chemical composition shape analgesic efficacy and adverse-effect liability for Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and select cannabis-derived terpene…
Open article record in new tab ↗Background Patients with inflammatory bowel disease (IBD) increasingly use cannabis. Studies investigating the effectiveness and safety of cannabis as a therapeutic option for IBD have reported conflicting findings, and recent reviews have not incorporated evidence from real-world studies. This systematic review assessed controlled non-interventional studies and interventional trials evaluating the effectiveness o…
Hemp is a high-yield crop traditionally cultivated for fiber used in products such as paper, textiles, ropes, and animal bedding, and more recently for sustainable applications in biofuels, insulation, and bioplastics. Beyond fiber, hemp is rich in phytochemicals. More than 500 compounds including cannabinoids, terpenes, phenolics, phytosterols, and tocopherols are accumulated in leaves, flowers, and seeds, which…
Open article record in new tab ↗Sublingual (SL) drug delivery represents an important alternative route of analgesic administration, particularly in settings where rapid pain control is desired or oral and parenteral routes are limited. By enabling direct absorption through the oral mucosa, SL administration partially bypasses first-pass hepatic metabolism, potentially improving bioavailability and accelerating the onset of action for select med…
Open article record in new tab ↗Objectives Poor adherence to psychopharmacological treatment may contribute to relapses in bipolar disorder (BD). We performed a systematic review and meta-analysis to identify factors associated with poor adherence in BD. Methods The protocol was registered in Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/2KZFJ). We searched main electronic databases through March 2025. Random-effects meta-an…
Growing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular levels. The endocannabinoid system has emerged as a key regulator of brain homeostasis during aging, interfacing with neuroinflammation, neurogenesis, and blood-brain barrier integrity. However, the neurological impact of exogenous cannabinoids in the aging brain remains incomplete…
The endocannabinoid system is a neuromodulatory network regulating synaptic plasticity, neuronal activity, and neuroinflammatory responses in both the central and peripheral nervous systems. The endocannabinoid system comprises endogenous ligands, termed endocannabinoids, and two principal receptors, cannabinoid receptor type 1 and type 2 (CB1R and CB2R). While CB1R is predominantly associated with the central ner…
Open article record in new tab ↗Introduction Cannabidiol (CBD), a nonpsychoactive compound derived from Cannabis sativa, has shown potential to influence cellular processes that are important for dental tissue repair. The aim of this scoping review was to map in vitro studies evaluating the influence of CBD on the osteogenic/odontogenic differentiation of human dental pulp stem cells (hDPSCs) in order to contribute to a better understanding of i…
Phytocannabinoids have received attention for their therapeutic properties, however, it is unclear how they affect bone homeostasis. Additionally, increased use of cannabis and hemp-derived products have raised questions about their impact on musculoskeletal health. This review summarizes recent studies that investigate the impact of phytocannabinoids on bone. The most well studied phytocannabinoid in relation to…
Open article record in new tab ↗Background Although current treatment guidelines recommend against cannabinoids for Post-Traumatic Stress Disorder (PTSD), their use has increased in clinical settings despite fragmented evidence. This review critically examines the efficacy, effectiveness, and safety of cannabinoid-based interventions for PTSD. Methods We conducted a scoping review following PRISMA-ScR guidelines. Five databases were searched up…
Open article record in new tab ↗BACKGROUND: Interest in cannabis extracts for chronic pain, including osteoarthritis (OA), is growing. This systematic review evaluated the efficacy of cannabis extracts in OA across preclinical and clinical studies. METHODS: A comprehensive literature search was performed using Medline via Ovid, Embase via Ovid, CINAHL, and Cochrane Central Register of Controlled Trials database to identify studies published up t…
Open article record in new tab ↗Anxiety disorders are associated with impaired inhibitory neurotransmission mediated by γ-aminobutyric acid type A (GABA-A) receptors. Although benzodiazepines remain effective anxiolytics, their clinical utility is limited by sedation, cognitive impairment, tolerance, and dependence, prompting the search for mechanistically distinct GABAergic modulators. Among cannabinoid-related molecules, the strongest evidence…
The EILAT Conferences on New Antiepileptic Drugs (AEDs), which have taken place biennially since 1992, have traditionally offered a forum for stakeholders from industry and academia to present updates on potential antiseizure medications (ASMs) in development. We reviewed publicly accessible data on compounds that were presented at EILAT conferences over this period but failed to reach the ASM market. The overarch…
Open article record in new tab ↗Background With regard to laparoscopic approach, the objective arises whether standard multiorgan Whipple resection (PD) or parenchyma-sparing procedures (DPPHRt) are the most qualified surgical treatments for benign, premalignant neoplasms. Methods Pubmed, Embase, Medline, and Cochrane Libraries were searched for studies reporting results and late outcomes after laparoscopic DPPHRt (L-DPPHRt) and laparoscopic PD…
BackgroundThe therapeutic potential of Cannabis sativa has attracted growing interest in oncology. Its diverse phytochemicals, including cannabinoids, flavonoids, and terpenes, interact with oncogenic signaling pathways and the endocannabinoid system influencing tumour progression and therapeutic responses.ObjectiveThis review critically evaluates the molecular mechanisms by which Cannabis sativa phytochemicals mo…
Open article record in new tab ↗Prenatal alcohol exposure (PAE) leads to fetal alcohol spectrum disorder (FASD), the most common preventable cause of neurodevelopmental impairment. The classical narrative attributes the clinical picture of FASD exclusively to direct ethanol-induced brain injury. In the present review, we argue that this perspective is incomplete and leads to diagnostic errors, most often to the misdiagnosis of ADHD in children w…
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