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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
522 articles
Newest firstWe report the case of a 29-year-old male from the Indian subcontinent (a tuberculosis (TB)-endemic region) residing in Qatar, who presented with a three-day history of epigastric pain, dark urine, and pale stools. He had no known TB exposure, was HIV-negative, and had received the Bacillus Calmette-Guérin or BCG vaccination in childhood. Physical examination revealed scleral icterus without peripheral lymphadenopa…
Open article record in new tab ↗Introduction Post-stroke tremor and post-stroke thalamic pain (PS-TP) are common and often refractory conditions that significantly impact patients' quality of life. Conventional pharmacotherapy frequently provides inadequate relief, while cannabis has shown potential for managing movement disorders and pain; however, evidence supporting its efficacy remains limited. On the other hand, physiotherapy is well-docume…
Open article record in new tab ↗Takotsubo syndrome (TS), also known as stress cardiomyopathy, is a clinical condition characterized by transient left ventricular dysfunction in the absence of coronary artery disease findings. The most widely accepted mechanism suggests a trigger, either physical or emotional stress, which causes catecholamine release and results in myocardial stunning and contractility alterations. Clinically and analytically, i…
Open article record in new tab ↗Cannabinoid-based therapies have shown analgesic, anti-inflammatory, and wound-healing potential across veterinary species; however, clinical data on long-term use of THC-rich formulations in horses remain scarce. This case report describes the use of combined oral and topical THC-rich and CBD-rich full-spectrum cannabis oils as part of a palliative care strategy in a rescued horse with severe chronic disease. A s…
Anomalous pancreaticobiliary ductal union (APBDU) represents a congenital anomaly predisposing patients to biliary dilatation. This aberrant architecture facilitates the intermingling of pancreatic and biliary fluids, thereby elevating susceptibility to cholelithiasis and malignancies of the biliary tract. While radical cholangiojejunostomy constitutes the standard therapeutic intervention, it frequently fails to…
BackgroundFollowing the recent amendments in international legislations on cannabis, semi-synthetic cannabinoid derivatives have become increasingly available worldwide. These new psychoactive substances are obtained through chemical modifications of cannabidiol (CBD), a widely available legal compound, or through chemical synthesis from fitting precursors. Compared to Δ9-tetrahydrocannabinol (Δ9-THC), the primary…
Background Maturity-onset diabetes of the young (MODY) is a rare monogenic diabetes with significant renal risk, especially when combined with hyperglycemia, obesity, and other factors. While chronic cannabis use may further accelerate kidney decline, no previous reports have described rapid progression to ESRD in a young patient with MODY, obesity, hypertension, and cannabinoid hyperemesis, as presented here. Cas…
Purpose A powder found at a fatality scene, labeled as the synthetic cathinone 3',4'-methylenedioxy-α-pyrrolidinohexiophenone (MDPHP) and most likely smoked using a crack pipe, was analyzed. The powder was identified as very potent synthetic cannabinoid ADB-BUTINACA/ADB-BINACA with a high purity (> 98%). This case highlights the risks associated with mislabeled novel psychoactive substances (NPS), particularly tho…
We report a rare complication of prophylactic pancreatic duct stenting during ERCP for suspected hilar cholangiocarcinoma. A 47-year-old woman presented with two weeks of painless jaundice, total bilirubin 18 mg/dL, and cholestatic enzymes. Imaging revealed intrahepatic biliary dilation without CBD dilation. ERCP with cholangioscopy identified a right hepatic duct stricture; biopsies were obtained. A 10 mm × 4 cm…
Open article record in new tab ↗Priapism is an uncommon but serious urological emergency, defined as a persistent penile erection unrelated to sexual stimulation. If not promptly treated, it carries a significant risk of permanent erectile dysfunction. Among pharmacologically induced causes, antipsychotic medications are frequently implicated. We describe the case of an 18-year-old male diagnosed with cannabis-induced psychosis who developed acu…
Open article record in new tab ↗Introduction and importance:Lemmel syndrome (LS) is a rare cause of obstructive jaundice resulting from compression of the distal common bile duct (CBD) by a periampullary duodenal diverticulum. The diagnosis is frequently missed due to nonspecific clinical features and subtle radiologic findings.Case presentation:A 39-year-old woman presented with recurrent epigastric pain, fever, and jaundice. Laboratory results…
Situs inversus totalis (SIT) is a rare congenital condition characterized by a complete mirror-image reversal of the thoracic and abdominal organs. Although usually asymptomatic, SIT poses significant challenges during diagnostic and therapeutic procedures due to reversed anatomy. Endoscopic retrograde cholangiopancreatography (ERCP) is the standard treatment of biliary and pancreatic ductal diseases, yet it becom…
Open article record in new tab ↗A variety of etiologies can lead a patient to present with symptoms that appear manic. A wide differential should be considered, including delirium, which may in turn be caused by multiple etiologies. Substance ingestion, specifically of dietary supplements, is one potential trigger that is not always considered. A 40-year-old male patient with a history of long-standing attention-deficit/hyperactivity disorder (A…
Open article record in new tab ↗We describe a 35-year-old Caribbean-Black male patient with a significant cannabis history who presented with an inferior ST-segment-elevation acute coronary syndrome (STE-ACS), with advanced heart block during active, ongoing cannabis consumption. During primary percutaneous coronary intervention, cineangiography revealed substantial thrombus burden in the first acute marginal branch of the right coronary artery.…
AbstractSeptate common bile duct (CBD) is a rare congenital anomaly resulting from incomplete recanalization of the primitive biliary tract. Although often asymptomatic, it predisposes to bile stasis, chronic inflammation, and potential malignant transformation. Distal cholangiocarcinoma arising in association with a septate CBD is exceptionally rare. We report the case of an 84-year-old male presenting with progr…
Synthetic cathinones, frequently used in chemsex, are difficult to identify in postmortem blood due to their short half-life and in vitro degradation. This unusual case of chemsex involving 3-CMC highlights the importance of freezing a blood aliquot and testing for metabolites. A 62-year-old man was found dead with chemsex paraphernalia beside him. Peripheral blood with sodium fluoride (PB), cardiac blood (CB) and…
Open article record in new tab ↗Background A 38-year-old woman with a 32-year history of recurrent biliary stones (cholecystectomy at age 6 and open choledochotomy with 6-month T-tube indwelling at age 16) presented with 2 h of postprandial right upper quadrant pain. Laboratory tests showed mild hyperbilirubinemia (total bilirubin 24.4 μmol/L, direct bilirubin 8.4 μmol/L) and elevated alanine transaminase of 287 U/L. Abdominal CT scan revealed c…
Premacular subhyaloid hemorrhage is an uncommon cause of acute visual impairment and is most frequently associated with Valsalva, trauma, hypertension, retinal vascular disease, or hematologic disorders. However, idiopathic cases have been described, suggesting the possibility of additional contributing factors. We describe the case of a 25-year-old man who presented with sudden unilateral visual loss two hours af…
Open article record in new tab ↗INTRODUCTION: Cannabinoid hyperemesis syndrome (CHS) is a debilitating disorder of chronic, heavy cannabis users characterized by cyclic severe nausea, vomiting, and abdominal pain that is classically relieved by hot baths. Standard antiemetics often fail, and dysregulation of endocannabinoid signaling with involvement of heat-sensitive TRPV1 channels has been proposed. Topical capsaicin - a TRPV1 agonist - has be…
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