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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
45 articles
Newest firstBackground: Traumatic brain injury (TBI) imposes a substantial public health burden through long-term physical, cognitive, and psychiatric effects. This includes substance use disorders (SUDs) for which TBI is a demonstrated risk factor; however, prior studies have not comprehensively compared relative incidences of SUD subtypes post-TBI or differences between intracranial hemorrhage (ICH) and non-ICH TBI in patie…
Open article record in new tab ↗BACKGROUND: Psychotic disorders substantially impact individuals psychologically, occupationally, and socially. Although modifiable risk factors such as insecure attachment styles, history of psychological trauma, and substance use disorders (of which cannabis is the most frequent) are known to increase risk, it remains unclear how they may interact with each other to create pathways of vulnerability. More importa…
Open article record in new tab ↗Most adolescents and young adult victims of firearm violence survive, yet the mental and behavioral health outcomes associated with these incidents remain understudied. Given the potential for recurrent violence victimization and long-term psychosocial sequela after being shot, understanding the experiences of firearm injury survivors is a critical area for development. We conducted a qualitative study to explore…
Introduction Facial trauma is a public health concern, with reports of about 25% of all traumas having a component of facial injury. Alcohol and illicit drug use have previously been shown to exacerbate the severity of trauma injuries. This study investigates the relationship between illicit drug use and clinical outcomes amongst patients presenting with facial fracture injuries. Methods A retrospective multicente…
Open article record in new tab ↗Background Sexual and gender minority (SGM) youth are at elevated risk for adverse mental health and substance use outcomes. Stressors such as family conflict, discrimination, and trauma have been suggested as possible mediators of these disparities. Aims This study examined whether family conflict, discrimination, and trauma mediate the associations between SGM identity and adverse outcomes, including suicide att…
Post-traumatic stress symptoms (PTSSs) are associated with an imbalanced time perspective (TP) as well as with unhealthy substance use. Although neurodevelopmental processes during adolescence may impact PTSS, most etiological models of post-traumatic stress disorder (PTSD) are derived from studies with adults and neglect possible distinctive characteristics in adolescent PTSD. This study examined possible direct…
Introduction As the legalization of cannabis becomes more widespread use has steadily increased. Approximately 5 percent of pregnant individuals self-report use during pregnancy. Methods This study uses a mixed methods approach to examine adverse childhood experiences, mental health needs, and cannabis use among a small sample (N =59) of women. Cumulative ACE scores of four or more were considerably high within th…
Open article record in new tab ↗Post-Traumatic Stress Disorder (PTSD) is a highly debilitating psychiatric disorder, which develops in a subset of trauma-exposed individuals. Patients with PTSD fail to extinguish fear responses to no-longer dangerous stimuli and develop enduring experiences of fear and anxiety. To advance the understanding of PTSD neurobiology, longitudinal and comprehensive clinical and molecular data are needed. Here we presen…
Open article record in new tab ↗Background While understanding how corticostriatal connectivity is associated with socioeconomic status (SES), trauma exposure, cognitive function, reward salience, impulsivity, and future substance use is essential to identifying neurobiological pathways that contribute to health disparities and behavioral outcomes, very few studies have tested the role of left caudate resting-state functional connectivity (rsFC)…
Open article record in new tab ↗IntroductionMigrants are drawn to high-income countries (HICs) for employment, often in sectors deemed difficult, risky, and low paying. However, they experience more injuries and deaths and face barriers to healthcare. The World Health Organization has highlighted migrant health as a priority. While Hargreaves et al. and others studied migrant occupational health, most did not compare with residents. Lau et al. a…
Open article record in new tab ↗BackgroundPost-Traumatic Stress Disorder (PTSD) affects 8-10% of trauma-exposed individuals globally (2), with significant gender disparities in prevalence and clinicalpresentation. The relationship between PTSD and substance use disorders creates complex comorbidity patterns requiring gender-sensitive approaches. ObjectiveTo examine gender-specific differences in PTSD symptom expression and addiction patterns amo…
Open article record in new tab ↗BackgroundThe Posttraumatic Stress Disorder Checklist (PCL-5) is one of the most widely used instruments for assessing posttraumatic stress disorder (PTSD), adapted to meet DSM-5 criteria. Establishing a validated online version for Spanish-speaking populations, particularly among healthcare professionals, is essential to ensure accurate assessment aligned with these updated criteria. AimThe purpose is to evaluate…
Head injuries are a leading global cause of mortality and disability, highlighting the critical need for advanced prognostic tools to inform clinical decision-making and optimize healthcare resource utilization. For the first time, this study introduces a cutting-edge artificial intelligence (AI) framework designed to predict mortality outcomes from head injury narratives. Leveraging deep learning-based natural la…
Substance use disorder (SUD) is a significant health problem, and trauma exposure is a known risk factor for the escalation of substance use. However, the shared neural mechanisms through which trauma is associated with substance use are still unknown. Therefore, we systematically review neuroimaging studies focusing on three domains that may contribute to the overlapping mechanisms of SUD and trauma-reward salien…
Background Various forms of interpersonal abuse (e.g., physical, emotional, sexual) and cannabis use across the lifespan have both been known to increase odds of psychotic experiences; however, there have been few studies examining their separate and joint effects in the United States. Methods We analyzed data from the Healthy Minds Study (2020-2021) and used multivariable logistic regression and interaction contr…
Background Metabotropic glutamate receptor 5 (mGlu5) dysregulation has been implicated in the pathophysiology of trauma-related psychopathology, and there are direct interactions between the endocannabinoid and glutamatergic systems. However, relationships between cannabis use (CU) and mGlu5 have not been directly investigated in trauma-related psychopathology. Methods Using positron emission tomography with [18F]…
BackgroundAlcohol use is a contributing factor in many cases of traumatic injury. There is conflicting evidence on the impact of alcohol use at the time of physical trauma on severity of injury and hospital course. Similarly, the significance of alcohol use disorder on outcomes in hospitalized trauma patients is unclear. This scoping review aims to provide a concise overview of the current literature surrounding p…
ABSTRACTBackground: The occurrence of attenuated psychotic symptoms (APS) is a major concern in populations with substance use disorders (SUDs). However, APS also frequently develop in the course of Post-Traumatic Stress Disorder (PTSD). This study explores how the prevalence of APS differs between adolescent patients with only SUD, SUD with a history of traumatic experiences (TEs), and with SUD and self-reported…
Open article record in new tab ↗PurposeSubstance misuse has long been recognized as a major predisposing risk factor for traumatic injury. However, there still exists no clear scientific consensus regarding the impact of drug use on patient outcomes. Therefore, this study aims to evaluate the demographic profile, hospital-course factors, and outcomes of trauma patients based on their toxicology.MethodsThis is a non-concurrent cohort study of 370…
Open article record in new tab ↗BackgroundA dissociative subtype of posttraumatic stress disorder, known as “D-PTSD”, has been included in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. In addition to meeting criteria for PTSD, patients endorse prominent dissociative symptoms, namely depersonalization and derealization, or detachment from one's self and surroundings. At present, this population is supported by a highly…