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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
35 articles
Newest firstBackground and Objectives: One of the strongest early factors influencing later psychoactive substance use is adverse childhood experiences (ACEs). Studies investigate a variety of adverse experiences in relation to substance use, yet not all adverse childhood experiences are equal in intensity and harm. Our study aimed to address this gap by examining in detail the associations between individual ACEs, broader AC…
Open article record in new tab ↗Purpose To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents. Method Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental (ch…
Background: Adverse childhood experiences (ACEs) are associated with adolescent substance use. However, the influence of individual ACEs after controlling for concurrent ACEs is understudied. Methods: Using longitudinal data from the Future of Families and Child Wellbeing Study (n = 3200), we evaluated binary logistic models to test associations from 11 individual ACEs at ages 3-9 (physical abuse; emotional abuse;…
Open article record in new tab ↗Abstract Background: Adverse Childhood experiences (ACEs) disproportionately affect minoritized and low-income youth. Those with four or more ACEs are particularly vulnerable to chronic, unpredictable stress, which shapes their stress perception and response. Higher exposure to ACEs is associated with an increased risk of self-dysregulation, early initiation of alcohol and substance use, and cardiometabolic issues…
BackgroundHistorically, U.S. adolescent boys have reported higher substance use than girls, but this has changed in recent years with girls reporting more use. The reasons for this demographic shift are unclear, but girls may be more likely to turn to substance use as a way to cope with stress and internalizing problems.MethodsWe used cross-sectional data from the 2023 Nevada Middle School Youth Risk Behavior Surv…
Introduction Substance use is frequently encountered in emergency department (ED) visits and may reflect underlying emotional or developmental challenges. Adverse childhood experiences (ACEs) are linked to both emotional dysregulation and later substance use, but this relationship is rarely examined in acute care settings. We investigated whether recent substance use, as measured by the Tobacco, Alcohol, Prescript…
Background and hypothesis Evidence suggests a complex interplay among childhood trauma (CT), substance use, and psychopathology in psychosis, yet the precise nature of these relationships remains unclear. Network analysis offers distinct advantages for examining these factors simultaneously, as it can capture multidirectional associations across multiple trauma subtypes, substances, and symptoms that conventional…
Rationale Adverse childhood experiences (ACEs) have been identified as a major risk factor for psychiatric disorders from childhood to adult life along with the dysregulation of neuroendocrinological processes mediating stress and inflammation. The endocannabinoid system (ECS) has been found to play a putative role in the release of inflammatory cytokines. Objective We investigated the role of the ECS in the inter…
Non-medical use of cannabis (NmC) and/or opioids (NmO) can lead to adverse health effects (AHEs), yet the proportion of these harms attributable to adverse childhood experiences (ACEs) remains unclear. This study estimated the contribution of ACEs to AHEs from NmC and/or NmO among adults aged ≥18 years using 2019-2020 Behavioral Risk Factor Surveillance System data from Arizona and Massachusetts. We conducted a re…
Background Early life stress (ELS) increases the risk of substance use disorder (SUD) in adulthood. The pathway from ELS to SUD is hypothesized to be influenced by sex. We examine the impact of ELS on adolescent first substance use, a common precursor to adult SUDs, and test for sex differences in the relationship between ELS and risk of first use of alcohol, nicotine, and marijuana. Methods Individuals from the A…
Introduction Adverse childhood experiences (ACEs) have been linked to chronic health conditions, at-risk behaviors, and reduced quality and length of life. Public health interventions targeting childhood trauma require an investigation of overall prevalence of ACEs and associations with outcomes and behaviors. Methods We created an ACE score using aggregated North Dakota (ND) Behavioral Risk Factor Surveillance Sy…
Open article record in new tab ↗Objective To examine the association between adverse childhood events (ACEs) and cannabis use among adult cancer survivors in the United States. Methods We conducted a cross-sectional study of cancer survivors ≥ 18 years old using 2020 Behavioral Risk Factor Surveillance System data. ACEs were categorized as 0, 1, 2-3, and ≥ 4. Weighted multivariable logistic regression estimated the odds of cannabis use by ACE ca…
Background Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay between childhood trauma, cannabis use, and paranoia using standard tetrahydrocannabinol (THC) units as a comprehensive measure of cannabis exposure. Methods Data were derived from th…
Background Exposure to Adverse Childhood Experiences (ACEs) is associated with increased risk of substance use in women, including cannabis use during pregnancy. Less is known, however, about how resilience factors moderate the association of ACEs on cannabis use in early motherhood. Methods We used survey data from 126 predominately low-income and diverse mothers enrolled in a longitudinal study in the South Cent…
Open article record in new tab ↗Background and hypothesis Psychotic disorders (PDs) have huge personal and societal impact, and efforts to improve outcomes in patients are continuously needed. Environmental risk factors (ERFs), especially modifiable risk factors, are important to study because they pose a target for intervention and prevention. No studies have investigated ERFs, cognition, and psychotic symptoms together in a network approach. S…
Adverse childhood experiences (ACEs) are recognized risk factors for later substance use. Yet, data remain scarce-particularly regarding the differentiated effects of specific types of ACEs and their distinct associations with various psychoactive substances. The current study is one of the first in Lithuania to explore the associations between specific ACEs and psychoactive substance use in young adulthood (ages…
Introduction As the legalization of cannabis becomes more widespread use has steadily increased. Approximately 5 percent of pregnant individuals self-report use during pregnancy. Methods This study uses a mixed methods approach to examine adverse childhood experiences, mental health needs, and cannabis use among a small sample (N =59) of women. Cumulative ACE scores of four or more were considerably high within th…
Open article record in new tab ↗This study aimed to 1) describe the prevalence of Adverse Childhood Experiences (ACE) in relation to the type of substance used (alcohol or cannabis) among adults seeking treatment for Substance Use Disorder (SUD) in Greenland, and 2) examine whether an association exists between ACE and the type of substance used (alcohol and/or cannabis). The analysis was conducted using register data from individuals receiving…
Background Genetic and environmental factors, including adverse childhood experiences (ACEs), contribute to substance use disorders (SUDs). However, the interactions between these factors are poorly understood. Methods We examined associations between SUD polygenic scores (PGSs), ACEs, and the initiation of use and severity of alcohol (AUD), opioid use disorder (OUD), and cannabis use disorder (CanUD) in 10,275 in…
Adverse childhood experiences (ACEs) can have lasting effects into adulthood. This study examines the relationship between ACEs and the frequency of substance use among high school students in the United States. Data were drawn from the 2023 Youth Risk Behavior Survey, a nationally representative survey of high school students. A cumulative ACE score was calculated based on 8 self-reported lifetime experiences. Mu…
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