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Research Article 2026CC BYFree full text

Relative Incidence of New-Onset Substance Use Disorders Following Traumatic Brain Injury: A Global Retrospective Multicenter Analysis Using the TriNetX Database.

Zachary T Hoglund, Christopher Sollenberger, Kyle W Scott, John D Arena, Visish M Srinivasan, Jan-Karl Burkhardt +8 more

Background: Traumatic brain injury (TBI) imposes a substantial public health burden through long-term physical, cognitive, and psychiatric effects. This includes substance use disorders (SUDs) for which TBI is a demonstrated risk factor; however, prior studies have not comprehensively compared relative incidences of SUD subtypes post-TBI or differences between intracranial hemorrhage (ICH) and non-ICH TBI in patie…

Journal of Clinical Medicine Europe PMC

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Research Article 2026-04-23CC BY-NCFree full text · non-commercial reuse

Addition of Bupropion or Varenicline to Nicotine Replacement Therapy After Acute Coronary Syndrome: A Propensity-Matched Real-World Analysis

Abdul Qadeer, Najam Gohar, Pankti Maniyar, Lorena Mata Juarez, Nimra Shafi, Shiva Raju Gollapally Krishna +4 more

IntroductionSmoking cessation after acute coronary syndrome (ACS) is a Class I recommendation, yet prescription pharmacotherapy use remains low and its real-world cardiovascular effectiveness when added to nicotine replacement therapy (NRT) is poorly characterized. MethodsWe conducted a retrospective cohort study using the TriNetX US Collaborative Network (67 healthcare organizations). Adults hospitalized with ACS…

medRxiv medRxiv