Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
408 articles
Newest firstObjective This study aimed to construct a high-efficiency dual-modal diagnostic model for treatment-resistant depression (TRD) by integrating serum metabolomics and clinical risk factors, and explore its metabolic pathological mechanisms. Methods A total of 93 major depressive disorder (MDD) patients (53 TRD, 40 non-TRD) were enrolled for a single-center retrospective study. Serum untargeted metabolomics and clini…
Open article record in new tab ↗[This corrects the article DOI: 10.3389/fpsyt.2026.1816611.].
Open article record in new tab ↗Adolescent depression emerges during a developmental period characterized by ongoing maturation of corticolimbic and stress-regulatory systems. This narrative review critically evaluates a hypothesis that acute exercise-related endocannabinoid mobilization, particularly changes in circulating anandamide (AEA), may be linked to CB1 receptor (CB1R)-dependent processes relevant to prefrontal–amygdala function and str…
IntroductionCompulsive Sexual Behavior Disorder (CSBD) and problematic pornography use (PPU) frequently co-occur with substance use disorders, yet their associations with specific substances in non-clinical populations remain poorly understood. The present study examined associations between alcohol and cannabis use severity and CSBD and PPU symptoms in a non-clinical adult sample.MethodsEligible adults were invit…
Open article record in new tab ↗Introduction Cannabis is one of the most widely used psychoactive substances and is associated with negative consequences affecting physical and mental health, cognition, quality of life, functional outcomes, employment, and interpersonal relationships. The impact of cannabis use varies between individuals and is not necessarily related to consumption quantity or frequency. This variability underscores the importa…
Introduction Evidence suggests an association between chronic psychoactive substance use and memory deterioration. Autobiographical memory (AM) is one form of long-term memory that is captured through specific personal information. Exploring potential causes of AM impairment is crucial as these memories shape identity and are important for problem solving and imagining the future. This is the first systematic revi…
Open article record in new tab ↗Aim High-frequency repetitive transcranial magnetic stimulation (rTMS) targeting the dorsolateral prefrontal cortex (DLPFC) shows promise in treating substance use disorders, but its efficacy for cannabis use disorder (CUD) is less well established. This 12-month, two-phase, three-arm, prospective, open-label study evaluated the short- and long- term effects of high-frequency rTMS over the left DLPFC in individual…
Open article record in new tab ↗Major depressive disorder (MDD) refers to a complex mental disorder defined by hindered reward system and hindered stress resilience. The limitations of traditional monoamine antidepressants have prompted the academic community to study new pathological processes and intervention strategies. Major depressive disorder arises from a complex interplay of psychological, social, and biological factors. Among the latter…
Open article record in new tab ↗IntroductionNeuronal mechanisms of motion perception are susceptible to developmental anomalies. We tested whether heavy adolescent cannabis use is associated with enduring deficits in global motion perception, with relative sparing of global form perception, in abstinent adults.MethodsIn a cross-sectional study, 130 adults were enrolled: cannabis-naïve controls (n=50), non-heavy adolescent users (n=38), and heavy…
Open article record in new tab ↗Background and hypothesis Cannabis use initiation during adolescence has increased globally, raising concerns about neurodevelopmental consequences during this critical period when the brain undergoes extensive remodeling in cannabinoid receptor-rich regions. Study design This systematic review examines neurodevelopmental consequences of adolescent cannabis use, focusing on structural brain changes, cognitive impa…
Open article record in new tab ↗IntroductionCannabis use during pregnancy and the postpartum period has increased in recent years, raising clinical concerns regarding maternal and infant health, particularly during lactation. However, evidence regarding Δ9-THC concentrations in breast milk during the early postpartum period and their relationship with other biological matrices remains limited.ObjectiveThis study aimed to assess Δ9-THC concentrat…
Open article record in new tab ↗Introduction Pregnant women with criminal justice-system involvement (CJI) and substance use disorders (SUD) face considerable barriers that impact substance use treatment outcomes. However, limited research has investigated such factors among this population. To address this gap, we investigated associations of sociodemographic and treatment-related factors with reduced substance use and treatment completion amon…
Open article record in new tab ↗IntroductionApproximately 20% of cancer patients report cannabis use, yet only 30% of oncologists feel sufficiently informed to make recommendations on its use. This study aimed to visualize the network of themes that arise within cancer patients’ reported experiences with cannabis.Materials and methodsData was collected via an online survey of 65 patients who self-reported the use of cannabis in their treatment f…
Open article record in new tab ↗Background At present, there are no approved pharmacological treatments for people at clinical high risk for psychosis (CHR-P). We sought to assess the acceptability of cannabidiol (CBD): a promising candidate treatment for this population. Methods CHR-P individuals completed a survey which assessed their views on the acceptability of CBD, its expected effectiveness and side effects, and on formulation preferences…
Open article record in new tab ↗Cannabis is one of the most widely used psychoactive substances, with higher use rates in countries that have implemented policies to legalize medical or recreational use. Following the development of cannabis products with concentrations well above 10% THC (high potency, delta-9 tetrahydrocannabinol), the number of psychosis cases has also increased. Cannabis-attributable psychosis cases increased from 1995 to 20…
Open article record in new tab ↗Introduction Approximately one-third of individuals with schizophrenia will meet the criteria for treatment-resistant schizophrenia (TRS), the majority of whom demonstrate poor pharmacological response early in their course of illness. Clozapine response is higher when used early in the illness trajectory; thus, there is a need to characterize the neurobiological underpinnings of TRS to support early stratificatio…
Introduction Meaning in life (MIL) refers to the sense that one's existence is coherent, purposeful, and significant. A growing body of research highlights the role of MIL in psychological well-being and resilience, as well as its inverse associations with psychological distress and problematic substance use. However, empirical work examining the joint and reciprocal relations between MIL, psychopathological sympt…
Open article record in new tab ↗Background Cannabis use has increased across Europe over the last decade, accompanied by growing availability of high-potency THC products and rising psychiatric presentations. Despite these trends, European countries differ substantially in monitoring systems, clinical preparedness and public health responses. These disparities are especially visible between Western Europe, which has more developed pharmacovigila…