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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
225 articles
Newest firstBackgroundCannabis use disorder affects a substantial proportion of the population and is often accompanied by mental health comorbidities, including depressive symptoms and problematic Internet use (PIU). This study explores the association between PIU and depressive symptoms among adults at high-risk of cannabis use disorder, a relationship insufficiently explored despite the high prevalence of these conditions…
Open article record in new tab ↗Alcohol use disorder (AUD) remains a pervasive public health issue with limited effective treatments. Cannabidiol (CBD), a non-psychotropic constituent of cannabis, shows promise in modulating addictive behaviors. This study investigated the effects of chronic CBD administration on alcohol dependence, withdrawal symptoms, and neurodegeneration using two complementary rodent models: chronic intermittent ethanol (CI…
Cannabis and tobacco use are highly prevalent among people with psychosis and are associated with medical comorbidities and poor prognosis. Concurrent use of cannabis and tobacco ('co-use') is rising in the general population, but has not been studied in psychosis. Given the devastating consequences of cannabis and tobacco use, it is critical to understand how their co-use affects psychiatric symptoms and the deve…
Open article record in new tab ↗Substance use has been associated with blunted brain responses to non-drug rewards, but findings in people who use cannabis are mixed. Adolescents may be uniquely vulnerable to cannabis-related disruption to reward processing due to ongoing neuromaturation, but longitudinal research is lacking. In this longitudinal fMRI study, we compared brain measures of reward anticipation in 46 adolescents (16–17 years) and ad…
Open article record in new tab ↗Polysubstance use disorders ( ≥ 2 substance use disorders (SUDs)) are associated with high morbidity and mortality. We analyzed data from 92,233 adult participants in the 2022-2023 US National Surveys on Drug Use and Health to estimate past-year prevalence of polysubstance use disorders and to examine their associations with age of substance use initiation. Multivariable logistic regression and Poisson regression…
Open article record in new tab ↗Background Gender identity influences patterns of substance use; however, few population-level studies have included transgender and gender-diverse identities when examining patterns of cannabis use by gender identity. Methods Data are from the International Cannabis Policy Study's national, repeat cross-sectional surveys conducted annually between 2018-2023 in Canada and the United States. Weighted logistic and l…
Open article record in new tab ↗Rationale The ongoing global opioid crisis underscores the need to better understand the neurobiological mechanisms underlying opioid use disorder (OUD). Stress is a key risk factor for developing and maintaining OUD. While animal models report that the endocannabinoid system (ECS) plays a modulatory role in stress response, alterations of ECS stress reactivity in individuals with OUD have yet to be studied. Objec…
Open article record in new tab ↗Cannabis was previously associated with worse memory function in men but not in women. As the hippocampus is crucial in the formation and retrieval of memory, we studied if cumulative exposure to cannabis is associated with differences in the hippocampal tissue volume, fractional anisotropy (FA) and cerebral brain perfusion (CBF) by MRI, overall and by sex, stratified by ever tobacco smoking, in multivariable adju…
Open article record in new tab ↗Background Conventional psychological and pharmacological substance abuse treatments are limited to moderate effect sizes and fail to magnify outcomes when combined. Analog psychedelic agents N, N-dimethyltryptamine (DMT) and 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) show therapeutic potential for treatment-resistant psychiatric disorders including substance addictions. Methods This systematic review and meta-…
This case report presents the case of a 25-year-old woman who developed ketamine addiction following a single sub-anaesthetic dose of intranasal ketamine in a pilot study investigating intranasal racemic ketamine for acute suicidality. She had a history of depression, obsessive-compulsive disorder, autism spectrum disorder and anorexia nervosa, and she had sporadically used alcohol and cannabis. Following the inte…
Open article record in new tab ↗BACKGROUND: The entopeduncular nucleus (EP) is a major output nucleus of the basal ganglia and plays a critical role in integrating motor, emotional, and behavioral processes. Although traditionally linked to motor control, accumulating evidence indicates that the EP is deeply involved in psychiatric disorders, sleep regulation, addiction, and mood-related behaviors. As the rodent homolog of the human internal Glo…
Open article record in new tab ↗Background: In experimental studies using the cue reactivity paradigm (CRP), classically conditioned substance craving is well-documented among individuals who use substances with trauma histories. However, the magnitude of this effect has not yet been quantified, nor have moderators of this relationship been identified [DeGrace, S., Romero-Sanchiz, P., Standage, C., & Stewart, S. H. (2022). A scoping review of th…
Introduction Meaning in life (MIL) refers to the sense that one's existence is coherent, purposeful, and significant. A growing body of research highlights the role of MIL in psychological well-being and resilience, as well as its inverse associations with psychological distress and problematic substance use. However, empirical work examining the joint and reciprocal relations between MIL, psychopathological sympt…
Open article record in new tab ↗Background Impaired inhibitory control has been observed in regular cannabis users. Theories suggest that regular cannabis use is maintained by reward-driven behaviour, which may be underpinned by adaptations in neural reward and inhibitory control systems, thus increasing vulnerability to dependency. Aims This study investigated neural correlates of cannabis cue-specific inhibitory control in regular cannabis use…
Background Substance use has consistently been linked with cognitive impairments. However, most previous studies have focused on highly selective samples of individuals with chronic substance use disorders and have typically relied solely on self-reports. The associations between recreational use patterns of single or multiple substances and cognitive functioning in representative samples remain unclear. Methods W…
Background: Experiential avoidance (EA) refers to the tendency to evade or suppress unpleasant internal experiences, such as distressing thoughts, emotions, or bodily sensations. Increasing evidence indicates that EA plays a central role in the onset and maintenance of addictive behaviours. Objective: To synthesise quantitative evidence on the association between experiential avoidance (EA), operationalised as psy…
Unsatisfactory sleep is a worldwide concern, as evidenced by the high prevalence of insomnia symptoms and diagnosis in the general population, and an issue that has also risen among adolescents. These circumstances are a cause of worry due to, among other factors, the observed bidirectional association of sleep disturbances and the risk of substance use disorder development. In this regard, across the globe, sever…
Open article record in new tab ↗College students use substances for varied reasons, including to cope with stress. The parasympathetic nervous system (PNS) regulates bodily functions to promote energy conservation (the 'rest and digest' response), and individuals differ in their physiological sensitivity to challenge. It remains unclear whether greater PNS responses (i.e., declines in PNS activity, termed vagal withdrawal) to challenge could sug…
Open article record in new tab ↗Addiction is increasingly recognized as a disorder involving not only reward dysregulation but also alterations in core cognitive processes, including learning and memory. Although various studies have documented memory impairments in substance use and behavioral addictions, evidence remains inconsistent-particularly regarding verbal memory deficits and the diagnostic relevance of specific recall error types. This…
Objectives Opioid use has significantly increased in Germany in recent years. This study aimed to evaluate and compare the oral health, dental hygiene, self-perceived pain, and functional limitations of opioid-addicted patients with a healthy control group. Materials and methods 50 opioid-addicted patients (OAP) attending substitution treatment at the Centre for Addiction Medicine of the Department of Psychiatry a…
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