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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
134 articles
Newest firstTakotsubo syndrome (TS), also known as stress cardiomyopathy, is a clinical condition characterized by transient left ventricular dysfunction in the absence of coronary artery disease findings. The most widely accepted mechanism suggests a trigger, either physical or emotional stress, which causes catecholamine release and results in myocardial stunning and contractility alterations. Clinically and analytically, i…
Open article record in new tab ↗The rapid emergence of synthetic cannabinoid receptor agonists (SCRAs) poses challenges for drug testing, particularly when analyzing urine samples due to the rapid metabolization of the parent compounds. In early 2023, two novel SCRAs were reported to the European Union Drugs Agency (EUDA): ADMB-3TMS-PrINACA and Cumyl-3TMS-PrINACA, which are both indazole SCRAs featuring a trimethylsilyl propyl moiety connected t…
In the last twenty years, synthetic cannabinoid receptor agonists (SCRAs), also frequently known as synthetic cannabinoids, have grown into one of the leading and structurally diverse types of new psychoactive substances. This has brought about major trouble for clinical and forensic work. Even though there have been significant advances in the field, there remain important gaps in the understanding of the mechani…
Open article record in new tab ↗Background Synthetic cannabinoids (SCs), such as Spice and K2, appeal to adolescents because they are inexpensive and often evade standard drug tests. We assessed associations between SC use and sports-related traumatic brain injuries (TBIs) among US adolescents. Methods We analyzed nationally representative Youth Risk Behavior Survey data from 2017-2021 (n = 27,482). Sports-related TBIs were defined as self-repor…
Open article record in new tab ↗Objectives Youth vaping in UK schools has escalated, with reports of vapes sold as THC products containing synthetic cannabinoid receptor agonists (SCRAs) and other illicit substances, prompting health emergencies. This pilot study aimed to determine the prevalence and types of illicit substances present in vapes confiscated from secondary schools to inform future public health surveillance and interventions. Stud…
Open article record in new tab ↗BACKGROUND: This study aimed to develop and validate a highly sensitive and reproducible liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of 5F-MDMB-PICA and MDMB-4en-PINACA in human serum, ensuring suitability for both forensic and clinical toxicology applications. METHODS: Drug-free serum samples were fortified with target analytes, extracted through solid-phase…
Open article record in new tab ↗Purpose The recreational use of synthetic cannabinoids (SCs) by adolescents and adults has markedly increased in recent years. Previous studies demonstrated that exposure to SCs is associated with multiple adverse health effects. Nevertheless, little is known about the effects of these substances on male fertility. The current study aimed to investigate the toxicological effects of subacute exposure to synthetic c…
ABSTRACTBackgroundKush, a synthetic drug combining cannabinoids and nitazene opioids, has emerged as a major public health concern in Sierra Leone, with reported prevalence and clinical severity increasing markedly as it was first identified. This review examines the health consequences of Kush use, the socioeconomic and structural drivers underpinning its spread, and the adequacy of health system and policy respo…
Background Synthetic cannabinoids (SC) are created as alternatives to delta-9-tetrahydrocannabinol (∆9-THC) and can cause serious side effects like hallucinations and death. The DEA has identified eleven concerning synthetic cannabinoids: ADB-BUTINACA, ADB-HEXINACA, ADB-4en-PINACA, ADB-FUBIATA, 4F-MDMB-BICA, 4F-ABUTINACA, FUB-144, FUB-AKB-48, 5F-EMB-PICA, 5Cl-AKB-48, and MDA-19. These compounds were tested in rode…
Background and objectives Synthetic cannabinoids (SCs) are new psychoactive substances associated with acute intoxications. Experimental data obtained under controlled and comparable conditions remain limited for this category of compounds. This descriptive, hypothesis-generating screening study aimed to characterize the acute toxicity profile of three SCs, JWH-007, AM-694, and MAB-CHMINACA. Materials and methods…
The continuous emergence of New Psychoactive Substances (NPS) poses a significant challenge to public health and forensic toxicology due to their unpredictable pharmacology and rapid turnover on the illicit market. This study describes the development and validation of a high-resolution screening method for the simultaneous detection of 90 NPS in oral fluid (OF), a matrix of choice for non-invasive sampling and ro…
Highlights What are the main findings? HU210 altered both the metabolome and proteome, whereas Cannabis extract altered the metabolome with minimal proteome change in GT1-7 cells.Five pathways—citrate cycle, pentose phosphate pathway, pyruvate, butanoate, and glycerolipid metabolism—were differentially regulated by HU210 and Cannabis extract. What are the implications of the findings? Distinct metabolome–proteome…
Forensic entomologists estimate minimum post-mortem intervals (PMImin) by measuring the development of larvae on decomposing bodies. Entomotoxicology assumes significance when the deceased had ingested drugs, as these may alter insect development and consequently the accuracy of PMImin estimations. 5F-ADB, ADB-BUTINACA, and MDMB-4en-PINACA are potent synthetic cannabinoid receptor agonists and drugs of abuse, link…
Synthetic cannabinoids (SCs) are a rapidly developing kind of novel psychoactive substance, frequently associated with acute intoxication and public health concerns. This study aimed to elucidate and compare the phase I metabolic pathways of two structurally related SCs, 5F-ADB-PINACA and 5F-ADBICA, using in vitro and in vivo models. Temporal metabolic profiling was performed to identify potential signature metabo…
Synthetic cannabinoids （SCs） have become the most diverse and widely abused class of new psychoactive substances in the world. Blood and urine are classic sample matrices for in vivo toxin analysis， but some SCs have high lipophilicity， and the concentration of parent drugs in urine is extremely low， making them difficult to detect. Metabolites need to be investigated， and SCs with similar structures can produce t…
Acute cannabinoids toxicity is an alarming toxicological problem. The current study aimed to compare children and adults with acute natural cannabinoids toxicity and highlight cases with acute synthetic cannabinoids (SCs) toxicity. This retrospective cross-sectional study was conducted on patients with acute cannabinoids toxicity admitted to Tanta University Poison Control Center from January 2019 to December 2023…
Open article record in new tab ↗5F-ADB, MDMB-4en-PINACA and ADB-4en-PINACA are three potent indazole-carboxamide synthetic cannabinoids (SCs) that have been widely abused in recent years. However, the pharmacological research on these compounds remains limited, especially in vivo research data. The purpose of the present study was to investigate the pharmacological effects of 5F-ADB, MDMB-4en-PINACA and ADB-4en-PINACA in mice, comparing their in…
Background/Objectives: High-performance affinity chromatography (HPAC) was used to investigate the binding affinity of a series of synthetic cannabinoids, a widely abused class of new psychoactive substances, to human serum albumin (HSA) and obtain insights into the binding sites. To better understand the recognition mechanisms, molecular docking studies were conducted. Methods: Binding affinity was assessed throu…
Open article record in new tab ↗Background Germany provides a worldwide almost unique legal framework for offenders with substance use disorders through § 64 of the German Criminal Code, mandating a two-year multimodal therapy including an in-house clinical treatment period followed by a reintegration phase with gradually reduced supervision. During this phase, lapses are often concealed, with synthetic cannabinoids (SCs) serving as a potential…
Open article record in new tab ↗Background Synthetic cannabinoids (SCs) are prevalent in prisons and among people who experience homelessness in the UK and can cause serious harms to people who use them. While it is currently not possible to test for SCs at the point of care (POC), a new method for doing so using fluorescence spectral fingerprinting has recently been developed. In this study, we aimed to outline the potential utility of POC SC t…