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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
277 articles
Newest firstBackground Cannabis use is increasingly common among collegiate athletes. While acute tetrahydrocannabinol (THC) effects are well documented, the chronic impact on game-speed cognition, defined as the ability to perceive, decide, and act within sub-second windows, remains poorly quantified. The current study examined whether chronic THC use degrades football specific game-speed cognition and reaction times. Method…
Open article record in new tab ↗Current tools for spatial omics analysis often face challenges in performing integrated transcriptomics and metabolomics analysis, in-depth biological interpretation, and user-friendly operation. To address this, we developed SMIntegration, the first web-based graphical platform designed specifically for integrated spatial metabolomics and transcriptomics analysis. Built with R/Shiny and deployed using Docker cont…
Highlights Public health relevance—How does this work relate to a public health issue? The stress of transitioning to and from adulthood may have a negative impact on college student performance and health outcomes.While in college, students face high rates of mental health disorders (anxiety, depression, suicidal ideation), substance use disorder, severe sleep deprivation, and poor nutrition. Public health signif…
Open article record in new tab ↗Synaptic transmission is dynamically regulated by neuromodulators. One well-studied example is cannabinoid receptor type 1 (CB1R)-mediated suppression of neurotransmitter release by reducing presynaptic Ca2+ influx. Recently, GPR55 was shown to regulate transmitter release through a mechanism distinct from that of CB1R. However, the presynaptic role of cannabinoid receptor type 2 (CB2R) remains unclear. Here we st…
Open article record in new tab ↗The off-label use of cannabidiol (CBD) has outpaced investigation. We assessed the effects of CBD in Angelman syndrome model mice lacking the Ube3a gene and found that chronic injection of CBD increased rapid-eye movement sleep during the dark cycle, restored "Siesta", improved sleep homeostasis, and reduced spontaneous seizures following flurothyl kindling.
Open article record in new tab ↗Delta-8 THC is a psychoactive cannabinoid typically synthesized from hemp, with similar intoxicating effects as delta-9 THC. Surging public interest alongside the lack of federal regulation of delta-8 THC has led to an unclear legal landscape and increasing safety concerns. Educating young adults about the dangers of delta-8 THC is imperative. The current study investigated the effects of a brief educational video…
Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β-adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus. Although hippocampal activation of cannabinoid type-1 receptors (CB1Rs) is known to impair ORM consolidation, the mechanisms underlying this effect remain uncle…
Tauopathies are neurodegenerative disorders characterized by intracellular accumulation of abnormal tau encoded by MAPT, yet their molecular mechanisms remain incompletely understood. We aimed to identify proteomic signatures associated with the primary tauopathies corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), as well as the secondary tauopathy Alzheimer's disease (AD), and to character…
IntroductionKratom and hemp-derived cannabinoid use has increased in the United States.ObjectiveAssess pharmacists’ perceived knowledge of kratom and hemp-derived cannabinoids and whether it improved following continuing education.MethodsThis cross-sectional survey was administered to participants immediately before and after attending a live, one-hour continuing education presentation regarding the pharmacology,…
Open article record in new tab ↗Introduction Organized sport promotes physical and psychological health in adolescents, improving emotional regulation, self-efficacy and resilience, which are essential for preventing addiction. This study validates an adapted ESTUDES scale for measuring consumption and risk perception in young athletes. Method Descriptive cross-sectional study with 914 adolescent footballers from Jaén and Granada (aged 12-18). T…
Open article record in new tab ↗Draft genome sequences of seven Bacillus strains isolated from Chelidonium majus seeds and six Pseudomonas strains isolated from Cannabis sativa roots and stems are reported. These genome sequences provide a foundation for functional and comparative genomic analyses to unravel potential traits associated with plant growth promotion and protection.
Objectives Youth vaping in UK schools has escalated, with reports of vapes sold as THC products containing synthetic cannabinoid receptor agonists (SCRAs) and other illicit substances, prompting health emergencies. This pilot study aimed to determine the prevalence and types of illicit substances present in vapes confiscated from secondary schools to inform future public health surveillance and interventions. Stud…
Open article record in new tab ↗AbstractAcute cannabis use and its primary psychoactive constituent tetrahydrocannabinol (THC) can induce postural dizziness, indicating increased risk of orthostatic instability. However, it is unknown if vulnerabilities persist the morning after bedtime THC consumption. This study investigated the influence of bedtime THC consumption on cardiovascular variables during an orthostatic challenge. Nine individuals w…
Cannabis use has increased significantly in recent years, yet its impact on local anesthetic efficacy in oral surgery remains poorly understood. This report analyzes the case of a 34-year-old male with history of chronic cannabis use who exhibited a hyperalgesic pain response and difficulty achieving adequate anesthesia during dental extraction in spite of standard anesthetic techniques. This atypical presentation…
Open article record in new tab ↗IntroductionOsteoarthritis (OA) is a chronic, progressive joint disorder with higher prevalence and pain severity in women than men. The endocannabinoid system (ECS) modulates pain and shows sexual dimorphism, yet sex-specific alterations in central ECS signalling in OA pain remain under-investigated.ObjectivesWe investigated sex-dependent differences in pain-related behaviours and central ECS signalling in the ra…
Marijuana (cannabis) and cannabinoids are getting global medical and recreational approvals in this era of the opioid epidemic. Both opiates and cannabis are often co-abused, and their use increases the risk of opioid and cannabis use disorders (OUDs and CUDs), and dependency. Opioid and cannabinoid systems share many neuromodulating and pharmacological effects by activating opioid and cannabinoid receptors, respe…
Open article record in new tab ↗The role of saturated fatty acid-induced immunometabolic stress in macrophage dysfunction during metabolic disease remains incompletely understood, particularly the interplay between inflammatory signaling and intracellular lipid handling. We employed a tightly controlled palmitic acid (PA)-based lipotoxicity model in PMA-differentiated U937-derived human macrophage-like cells to investigate how lipid excess resha…
Open article record in new tab ↗The endocannabinoid system (ECS) is involved in regulating immune functions in leukocytes. An inflammatory stimulus, specifically LPS, can modulate the activity of endocannabinoids (eCB) receptors, and eCB within the leukocytes can further exert either pro- or anti-inflammatory effects on the immune function of these cells. The effects of exogenous eCB on the cellular inflammatory responses of bovine leukocytes ar…
Open article record in new tab ↗This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2-q13.1 duplication or deletion syndromes (15q-DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5 (10-22.5) years, with a median (IQR) follow-up of 21 (14-33) months. Al…
Cannabidiol (CBD) is increasingly used for symptom relief in chronic conditions, yet its role in inflammatory bowel disease (IBD) remains underexplored. We surveyed 229 IBD patients and found that 10.5% used CBD, primarily for anxiety (54.2%), insomnia (41.7%), and pain (41.7%). Among users, 87.5% perceived benefit. Most users were female, and one-third were on biologics. These findings highlight the growing inter…