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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
81 articles
Newest firstTakotsubo syndrome (TS), also known as stress cardiomyopathy, is a clinical condition characterized by transient left ventricular dysfunction in the absence of coronary artery disease findings. The most widely accepted mechanism suggests a trigger, either physical or emotional stress, which causes catecholamine release and results in myocardial stunning and contractility alterations. Clinically and analytically, i…
Open article record in new tab ↗BackgroundFollowing the recent amendments in international legislations on cannabis, semi-synthetic cannabinoid derivatives have become increasingly available worldwide. These new psychoactive substances are obtained through chemical modifications of cannabidiol (CBD), a widely available legal compound, or through chemical synthesis from fitting precursors. Compared to Δ9-tetrahydrocannabinol (Δ9-THC), the primary…
Background Trigeminal neuropathic pain (TNP) is a chronic and debilitating condition frequently resistant to conventional pharmacological therapies. Although cannabinoids have emerged as a potential adjunctive treatment, objective clinical documentation of their effects in orofacial neuropathic pain remains limited. Case reports We report two female patients with refractory TNP-one post-traumatic and one idiopathi…
Postcholecystectomy clip migration (PCCM) is a rare but recognized complication following cholecystectomy. The clinical presentation of PCCM often mimics that of choledocholithiasis, with symptoms including right upper quadrant pain and obstructive jaundice. Although the exact mechanisms underlying clip migration remain unclear, several theories have been proposed in the literature. While most cases occur shortly…
Open article record in new tab ↗Cannabis use in older adults may have a broad range of effects in older adults impacting Mind, Mobility, Medications, Multi-complexity, and what Matters Most.
Open article record in new tab ↗Background A 38-year-old woman with a 32-year history of recurrent biliary stones (cholecystectomy at age 6 and open choledochotomy with 6-month T-tube indwelling at age 16) presented with 2 h of postprandial right upper quadrant pain. Laboratory tests showed mild hyperbilirubinemia (total bilirubin 24.4 μmol/L, direct bilirubin 8.4 μmol/L) and elevated alanine transaminase of 287 U/L. Abdominal CT scan revealed c…
Background and Clinical Significance: Breast cancer is the most frequent malignancy in women. Metastatic breast cancer is considered a treatable but incurable condition, with a median overall survival of only 2-3 years. Among its subtypes, triple-negative breast cancer (TNBC) accounts for a high proportion of breast cancer-related deaths. It is characterized by an aggressive clinical course, early recurrence, and…
This report describes the case of a 31-year-old male lumberjack with severe self-inflicted injuries, including the amputation of both auricles and the penis, under the influence of cannabinoids, mitragynine, and 7-hydroxymitragynine. Emergency surgery was performed, and psychiatric evaluation revealed substance-induced psychosis. The patient's motivation for reconstructive penile surgery led to abstinence from the…
Introduction Cholelithiasis is common following metabolic and bariatric surgery (MBS), with gallstones developing in up to one-third of patients due to rapid weight loss and metabolic changes. Procedures such as Roux-en-Y gastric bypass (RYGB) and one anastomosis gastric bypass (OAGB) alter gastrointestinal anatomy, complicating endoscopic access to the biliary tree and presenting challenges in the management of c…
Open article record in new tab ↗Rhabdomyolysis is a life-threatening complication and is sometimes, though rarely, induced by the use of synthetic cannabinoids. The pathophysiology is poorly understood. However, the effect is through the activation of G-protein coupled receptors. We discuss the case of a 48-year-old man who was a known case of muscle-invasive bladder cancer and received four cycles of neoadjuvant chemotherapy. An X-ray showed an…
Open article record in new tab ↗Background Coronary artery spasm (CAS) is a temporary, severe narrowing of the coronary arteries typically presenting with nitrate-responsive angina at rest, transient ischaemic ECG changes, and in some cases leading to silent myocardial ischaemia, acute myocardial infarction, life threatening arrhythmias and cardiac arrest. Case summary A 47-years-old man with a history of chronic coronary syndrome and a working…
Open article record in new tab ↗Background Tourette Syndrome (TS) is a childhood onset chronic disorder in which motor and vocal tics co-occur. Cannabinoids are a potential therapeutic option for otherwise treatment resistant patients. However, there is an ongoing debate regarding potential side effects. This is particularly important in relation to activities being necessary for daily life such as driving a car. Case presentation We present the…
Open article record in new tab ↗Autism spectrum disorder (ASD) has a long-standing history of being strongly associated with multiple psychiatric comorbidities, including substance use disorders (SUDs) and eating disorders (EDs) like anorexia nervosa (AN). ASD-specific features, including repetitive behaviors, constricted interests, cognitive rigidity, and obsessive fixations, are believed to make patients with ASD vulnerable to SUD and ED devel…
Open article record in new tab ↗Introduction Situs inversus totalis (SIT) is a rare congenital condition characterized by mirror-image transposition of the thoracic and abdominal viscera. Herein, we report a rare case of laparoscopic common bile duct exploration with choledochotomy and stone extraction in a patient with SIT and a history of total gastrectomy with Roux-en-Y (R-Y) reconstruction. Case presentation A 70-year-old woman with SIT and…
Cannabinoid hyperemesis syndrome (CHS) is an emerging disorder in chronic cannabis users, characterized by recurrent nausea, vomiting, severe abdominal pain, and compulsive hot bathing. We report a case of CHS complicated by profound lactic acidosis (lactate 6.1 mmol/L), highlighting this metabolic derangement as a secondary effect of severe dehydration and physiological stress from intractable vomiting and pain.…
Open article record in new tab ↗Introduction and importance Laparoscopic common bile duct (CBD) exploration with cholecystectomy in patients with situs inversus totalis (SIT) is technically demanding and warrants comprehensive knowledge of the mirror image anatomy along with laparoscopic orientation of the left upper quadrant. Case presentation In this case report, we present a female patient who presented with pain in the left hypochondrium, ye…
Open article record in new tab ↗Introduction Perforated peptic ulcer disease (PUD) is a critical condition that can present with atypical symptoms, leading to misdiagnosis and treatment delays. While PUD classically presents with peritonitis, rare cases may induce localized inflammatory responses, mimicking other abdominal pathologies such as acute cholecystitis. Presentation of case We report the case of a 29-year-old male with recurrent postpr…
Introduction Cannabis-based medicine (CBM) is recommended for the treatment of tics in otherwise treatment-resistant adult patients with Tourette syndrome (TS). However, evidence in children with TS is very limited. Long-term effects of CBM in this population are unknown. Case presentations We present two cases of long-term follow-up over six and five years, respectively, in male adolescents with TS who were admin…
Open article record in new tab ↗Introduction and importance Penile strangulation is a rare urological emergency first described in 1755, often resulting from foreign object entrapment leading to vascular compromise, oedema, and potentially necrosis or gangrene. It is associated with delayed presentation due to patient embarrassment and lacks standardized management protocols. This report emphasizes the clinical challenges and outcomes associated…
Open article record in new tab ↗Background Recurrence of common bile duct (CBD) calculi within 30 days following T-tube cholangiography is exceedingly rare. Case summary This article details an instance of choledocholithiasis involving a 1.2 cm × 0.9 cm stone located in the lower and middle segments of the CBD, identified 30 days after T-tube cholangiography, accompanied by multiple microstones. Magnetic resonance cholangiopancreatography reveal…
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