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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
267 articles
Newest firstIndustrial hemp is a chemically rich plant increasingly explored within sustainable production systems aimed at the full utilization of all plant fractions. While hemp inflorescences have been extensively investigated, the biological potential of seed-depleted infructescences remains largely underexplored. This study compared essential oils (EOs) distilled from inflorescences and seed-depleted infructescences of h…
Open article record in new tab ↗BackgroundThe therapeutic potential of Cannabis sativa has attracted growing interest in oncology. Its diverse phytochemicals, including cannabinoids, flavonoids, and terpenes, interact with oncogenic signaling pathways and the endocannabinoid system influencing tumour progression and therapeutic responses.ObjectiveThis review critically evaluates the molecular mechanisms by which Cannabis sativa phytochemicals mo…
Open article record in new tab ↗Background Micropropagation is an increasingly sought-after propagation method in the cannabis industry as growers seek to maximize production efficiency, improve multiplication rates and cultivate plants that are free from biotic stress. However, knowledge about the impact of micropropagation on cannabis is still limited in the scientific literature, as most studies have primarily focused on optimizing environmen…
Cannabinoid content can vary several-fold across Cannabis sativa L. cultivars that carry functional, closely related CBDA synthase (CBDAS) and THCA synthase (THCAS) alleles, a difference that coding-sequence variation among functional alleles does not fully explain. Structural and copy-number variation at the synthase loci, the functional or pseudogenised state of synthase alleles, and linkage at the B locus accou…
Hemp (Cannabis sativa L.) is one of the oldest cultivated plants in the world. It is a wind-pollinated and heterozygous species, and diverse phenotypes can occur within population varieties. In our study, three different hemp varieties-('Carmagnola Selected' (CS), 'Tiborszallasi' (TS) and 'Finola selection' (FS))-were grown. Based on visual characteristics, two, five and four phenotypes were identified within CS,…
Open article record in new tab ↗Draft genome sequences of seven Bacillus strains isolated from Chelidonium majus seeds and six Pseudomonas strains isolated from Cannabis sativa roots and stems are reported. These genome sequences provide a foundation for functional and comparative genomic analyses to unravel potential traits associated with plant growth promotion and protection.
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are persistent per- and polyfluoroalkyl substances (PFAS) of environmental concern that can interfere with plant growth and physiological processes. This study evaluated the morpho-physiological response and PFAS accumulation in hemp (Cannabis sativa L.), maize (Zea mays L.), and sunflower (Helianthus annuus L.) grown in soil-filled pots for 32…
Introduction Cannabis sativa L. roots are traditionally used to manage gastrointestinal (GI) disorders; however, experimental pharmacological evidence supporting these uses remains limited. This study investigated the chemical profile, safety, and GI-related pharmacological effects of an ethanolic extract of C. sativa roots (CEECs). Methods Chemical characterization was performed by spectrophotometric determinatio…
Cannabis (Cannabis sativa L.) has gained increasing agronomic, industrial, and therapeutic importance owing to its fiber, seed, and bioactive cannabinoid content. However, water limitation represents a major environmental constraint affecting cannabis growth, yield, and phytochemical composition. The increasing frequency and severity of drought events associated with climate change pose a growing challenge to agri…
Glandular trichomes (GTs) are epidermal outgrowths in which diverse specialised (secondary) metabolites are synthesised and stored. Cannabis (Cannabis sativa L.) and its close relative hop (Humulus lupulus L.) have pharmaceutical and industrial significance due to the presence of these metabolites in their GTs. We examined the conservation or divergence of the specific transcriptional programmes underlying GT biol…
Cannabis sativa L. is a multipurpose crop of increasing agricultural and medical relevance, whose productivity and phytocannabinoid profile are influenced not only by genotype and environmental factors but also by the composition of its microbiota. This review synthesizes current knowledge (2020-2026) on the rhizosphere and endophytic microbiota of hemp, with particular emphasis on plant growth-promoting bacteria…
Open article record in new tab ↗Cannabis sativa, long established as a cornerstone of the pharmaceutical and industrial fiber markets, represents a radical and underexplored platform for renewable energy innovation. In this Hypothesis and Theory framework, we introduce a novel, patented (Provisional Patent No. 63916615) dual-use bio-refinery paradigm. This model harnesses engineered cannabis photosynthesis to drive green hydrogen production with…
Open article record in new tab ↗Background/Objectives: Mental and neurological disorders contribute substantially to the global burden of disease, affecting people of all ages and backgrounds. As their prevalence increases with age, their overall impact is expected to grow in the coming decades. Although psychological and pharmacological treatments are available, many patients fail to achieve satisfactory outcomes, underscoring the need for impr…
As a traditional Chinese herbal medicine, Cannabis sativa holds broad prospects for application in the development of functional foods, pharmaceutical formulations, dietary supplements, and cosmetic products. However, the bioactivity of polysaccharides in C. sativa has been largely overlooked. In this study, crude C. sativa leaf polysaccharide (CSLP) was extracted using the hot-water extraction and ethanol-precipi…
Open article record in new tab ↗Nos últimos anos, a acelerada expansão do mercado de produtos de Cannabis medicinal (PCM) levou ao aumento do consumo e das demandas judiciais pleiteando PCM no Brasil. O objetivo do estudo foi analisar as indicações terapêuticas presentes nas demandas judiciais que pleiteiam PCM, ajuizadas contra a União, e frente às evidências científicas presentes na literatura. Foi realizado um estudo transversal, analisando-s…
Background Cannabinoids have attracted significant attention for their potential therapeutic application in cancer research. However, recent studies have reported antitumor activity of cannabidiolic acid (CBDA)-the acidic precursor of CBD-in breast cancer cells, involving modulation of cyclooxygenase signaling. To our knowledge, no investigations have examined the effects of CBDA on RNA expression and signaling pa…
Simple SummaryLeishmaniasis is considered a neglected tropical disease due to limited treatment options, increasing resistance to prioritized compounds, and high toxicity associated with treatment, necessitating the exploration of new potential treatment approaches with improved safety profiles. In this research, computational tools were used to evaluate the efficacy of certain natural bioactive compounds on Ornit…
Hemp (Cannabis sativa L.) is a multipurpose crop with significant industrial and therapeutic potential. This article reviews the various uses of hemp in production, building, food, cosmetics and medicine, focusing on its economic, environmental and health benefits. Industrially, hemp has been used for making fabrics, paper, bioplastics, construction materials and biofuels, because of its strong fibres, fast growth…
Open article record in new tab ↗Endophytic bacteria contribute to plant growth, stress tolerance, and pathogen resistance. Their effective use in agriculture requires the identification of strains that combine multiple beneficial traits with consistent performance across different field conditions. Accordingly, this study examines Bacillus and Pseudomonas endophytes isolated from Cannabis sativa L. and Chelidonium majus L. for plant growth promo…
Callogenesis is a fundamental step in plant biotechnology and tissue culture, providing the basis for multiple scientific and practical applications. In this study, the impact on callogenesis of different plant growth regulators was studied on Cannabis sativa L. (a non-commercial genotype of hemp), with the objective of identifying the most suitable combination for the establishment of vigorously growing, friable…
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