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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
23 articles
Newest firstBackgroundPopulation-level data on preclinical heart failure (HF) remain limited because most epidemiological studies focus on symptomatic HF. We therefore developed an administrative-data algorithm to classify HF stages across the national population and describe temporal trends, stage transitions, and mortality across the HF continuum. MethodsUsing a claims-based staging framework adapted from the Universal Defi…
Open article record in new tab ↗Heart failure (HF) is characterized by energy deprivation, calcium (Ca2+) handling alterations, and inflammation: effects associated with mitochondrial dysfunction. Cannabidiol previously prevented mitochondrial dysfunction. Thus, it may prevent HF progression. In mice with HF, subcutaneous cannabidiol attenuated cardiac fibrosis, hypertrophy, loss of ejection fraction, and inflammation; isolated cardiomyocytes pr…
Resistin, a cysteine-rich adipokine, exhibits significant species-specific divergence in its cellular origins and pathophysiological functions. In humans, it is primarily secreted by monocytes, macrophages, and bone marrow-derived cells, positioning it as a pivotal mediator of inflammation and cardiometabolic disease rather than a direct regulator of glucose metabolism. This review synthesizes current evidence on…
Open article record in new tab ↗Introduction: Congestive heart failure (CHF) is a major global health challenge and the leading cause of hospitalization in the U.S., with disproportionately high 30-day readmission rates among low-income and minority communities. Social drivers of health and substance use both influence CHF outcomes, yet the effect of substance use on short-term readmissions remains understudied. This study evaluated the associat…
ObjectiveHeart failure (HF) is a common disease among elderly individuals and is associated with poor quality of life and prognosis. Individuals at risk of developing HF are often already patients in primary healthcare, but it is often a difficult diagnosis at an early stage. Identifying patients at high risk for HF and initiating early treatment is crucial for their outcomes. Using the variables gender, age, mult…
Open article record in new tab ↗BackgroundTo quantify the economic burden and health-related quality of life (HRQoL) impact of heart failure (HF) in the U.S., stratified by age and diabetes status. MethodsUsing a micro-level, bottom-up prevalence-based approach from a payer perspective, we analyzed healthcare costs from the Optum Research Database (ORD). HF prevalence and HRQoL via EuroQol 5-Dimensions and Healthy Days instruments were estimated…
Open article record in new tab ↗Heart failure (HF) prediction models using machine learning (ML) must achieve a balance between performance, fairness, and real-world clinical utility. This paper assesses the potential of ML and DL models in the context of heterogeneous databases (UCI, MIMIC) and aims to derive applicable schemes for equitable deployment in healthcare. Although the Transformer models depicted notable AUC-ROC in the UCI data (0.98…
BackgroundThe Veterans Health Administration (VA) healthcare system cares for almost 200,000 Veterans with heart failure with reduced ejection fraction (HFrEF). It is not known how this population fared regarding continuity of care quality measures and access over the past 6 years, including the COVID-19 pandemic and its aftermath. This study aimed to evaluate temporal trends in heart failure care delivery and ide…
IntroductionHealthcare systems were reorganised in 2020 to manage the COVID-19 pandemic. Despite their urgent status, hospital admissions for acute heart failure (AHF) were reported to decline from 9% to 66% worldwide between 2020 and 2021, with divergent findings regarding in-hospital mortality. This study aimed to investigate in detail the evolution of AHF hospitalisations and in-hospital mortality in France fro…
Background The prevalence of heart failure (HF) is increasing among young adults in the United States with pervasive racial and ethnic differences in this population. Objective To evaluate contemporary associations between race and ethnicity, clinical comorbidities, and outcomes among young to middle-aged adults with HF. Methods A retrospective analysis was performed using the National Health and Nutrition Examina…
Cirrhotic cardiomyopathy is defined as systolic and diastolic dysfunction in patients with cirrhosis, in the absence of any primary heart disease. These changes are mainly due to the malfunction or abnormalities of cardiomyocytes. Similar to non-cirrhotic heart failure, cardiomyocytes in cirrhotic cardiomyopathy demonstrate a variety of abnormalities: from the cell membrane to the cytosol and nucleus. At the cell…
No consensus exists for heart transplant listing for patients who use cannabis. We conducted a web-based survey to assess knowledge, and practice patterns towards patients with heart failure who use cannabis referred for transplant. A total of 140 clinicians (cardiologists (41.4%, n = 58), surgeons (7.1%, n = 10), pharmacists (9.3%, n = 13), advanced practice providers and coordinators) responded and responses wer…
Open article record in new tab ↗Background Pulmonary hypertension (PH) can cause right ventricular (RV) failure and subsequent cardiohepatic syndrome referred to as congestive hepatopathy (CH). Passive blood stasis in the liver can affect inflammation, fibrosis, and ultimately cirrhosis. Cannabidiol (CBD) has many beneficial properties including anti-inflammatory and reduces RV systolic pressure and RV hypertrophy in monocrotaline (MCT)-induced…
Understanding molecular traits through metabolomics offers an avenue to tailor cardiovascular prevention, diagnosis and treatment strategies more effectively. This study focuses on the application of machine learning (ML) and explainable artificial intelligence (XAI) algorithms to detect discriminant molecular signatures in heart failure (HF). In this study, we aim to uncover metabolites with significant predictiv…
Open article record in new tab ↗Introduction and AimDiabetes is a global health emergency with increasing prevalence and diabetes-associated morbidity and mortality. One of the challenges in optimising diabetes care is translating research advances in this heterogenous disease into clinical care. A potential solution is the introduction of precision medicine approaches into diabetes care. We aim to develop a digital platform called intelligent D…
Heart failure (also known as HF) is a clinical disorder triggered by functional and structural defects in cardiac muscles causing blood ejection or damage of ventricular filling. Even though the progression in the field of medicine, HF control, which generally presents as a syndrome, has been a task to healthcare sources. This is reproduced by the comparatively higher ration of readmissions with enhanced disease a…
Open article record in new tab ↗BACKGROUNDSarcoidosis is a multi-systemic granulomatous inflammatory disorder. In the setting of cardiac involvement, clinical manifestations include ventricular arrhythmias, high-grade atrioventricular block (AVB) and heart failure (HF). The impact of HF in patients with sarcoidosis has not been established from real-world data. METHODSPatients admitted with sarcoidosis from 2010-2019 were identified from the Nat…
Cardiac dysfunction associated with cirrhosis in the absence of preexisting heart disease is a condition known as cirrhotic cardiomyopathy (CCM). Cardiac abnormalities consist of enlargement of cardiac chambers, attenuated systolic and diastolic contractile responses to stress stimuli, and repolarization changes. CCM may contribute to cardiovascular morbidity and mortality after liver transplantation and other maj…
Open article record in new tab ↗Aberrant carotid body chemoreceptor (CBC) function contributes to increased sympathetic nerve activity (SNA) and reduced renal blood flow (RBF) in chronic heart failure (CHF). Intermittent asphyxia (IA) mimicking sleep apnea is associated with additional increases in SNA and may worsen reductions in RBF and renal PO2 (RPO2) in CHF. The combined effects of decreased RBF and RPO2 may contribute to biochemical change…
Cachexia may be caused by congestive heart failure, and it is then called cardiac cachexia, which leads to increased morbidity and mortality. Cardiac cachexia also worsens skeletal muscle degradation. Cardiac cachexia is the loss of edema-free muscle mass with or without affecting fat tissue. It is mainly caused by a loss of balance between protein synthesis and degradation, or it may result from intestinal malabs…