Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
15 articles
Newest firstBackgroundThis study compared prevalence of youth substance use by gender and type of chronic health condition (CHC); estimated gender-stratified odds of substance use across CHCs; and, contrasted effect sizes across CHCs and genders.MethodsData come from 13,580 youth 12 to 17 years in the 2019 Canadian Health Survey on Children and Youth (48.7% girls). CHC was categorized as none (38.4%), physical only (39.8%), m…
Open article record in new tab ↗Depression is accompanied by considerable comorbidity and excess mortality. We examined multimorbidity data using the validated pharmacy-based Rx-Risk Comorbidity Index and examined healthcare costs associated with chronic illness burden in the Australian Genetics of Depression Study (AGDS). Australian Pharmaceutical Benefits Scheme (PBS) record linkage for 15,890 AGDS participants was available from 01/07/2013-31…
Open article record in new tab ↗BackgroundMultiple long-term conditions (MLTC) are increasingly common and place significant strain on healthcare systems designed around single-organ conditions, often resulting in fragmented and reactive care for people living with MLTC. There is limited understanding of how health care professionals (HCPs) make decisions for and with individuals with MLTC at the point of hospital presentation. This study examin…
IntroductionAcute myocardial infarction (AMI) remains a leading cause of mortality, with the coexistence of other conditions (i.e., multimorbidity) complicating management and outcomes. Currently, healthcare providers see major challenges in consideration of the patient with a multimorbid profile, especially as this is a progressive issue where the temporal evolution of diseases is complex in nature, with a profou…
ObjectiveHeart failure (HF) is a common disease among elderly individuals and is associated with poor quality of life and prognosis. Individuals at risk of developing HF are often already patients in primary healthcare, but it is often a difficult diagnosis at an early stage. Identifying patients at high risk for HF and initiating early treatment is crucial for their outcomes. Using the variables gender, age, mult…
Open article record in new tab ↗BackgroundObstructive sleep apnea (OSA) is associated with a wide range of comorbidities, but large-scale phenome-wide analyses in clinical biobanks remain under-reported. In this study, we identified common comorbidities enriched in patients with OSA, tested the temporality of these associations, and analyzed relevant associations with summary sleep recording data. Methods48,251 participants with OSA in the Mass…
Open article record in new tab ↗Multimorbidity, the presence of multiple chronic health conditions, is a leading cause of death globally. In Malawi, chronic noncommunicable and communicable diseases such as HIV frequently co-exist, putting pressure on an under-resourced system. However, the health system is primarily structured around disease-specific (vertical) programs, which hinders person-centred care approaches to multimorbidity. Our study…
Open article record in new tab ↗BackgroundMultimorbidity, the coexistence of two or more chronic medical conditions, poses significant challenges for healthcare systems in sub-Saharan Africa (SSA), where single-disease-focused approaches currently predominate. Despite the rising burden of multimorbidity in SSA region, data on its clinical management in hospitals is limited. This study aimed to explore healthcare worker experiences in the managem…
The global population is undergoing a significant surge in aging leading to increased susceptibility to various forms of progressive illnesses. This phenomenon significantly impacts both individual health and healthcare systems. Low and Middle Income Countries face particular challenges, as their Primary Health Care (PHC) settings often lack the necessary human and material resources to effectively address the esc…
Open article record in new tab ↗BackgroundNon-adherence to prescribed medication regimens can lead to suboptimal control of chronic health conditions and increased hospitalizations. Older adults may find it particularly challenging to self-manage medications due to physical and cognitive limitations resulting in medication non-adherence. While automated medication dispensing technologies may offer a solution for medication self-management among…
Multimorbidity is an emerging challenge for healthcare systems globally. It is commonly defined as the co-occurrence of two or more chronic conditions in one person, but the suitability and utility of this concept beyond high-income settings is uncertain. This article presents the findings from an interdisciplinary research initiative that drew together 60 academic and applied partners working in 10 African countr…
Open article record in new tab ↗MotivationMultimorbidity, characterized by the simultaneous occurrence of multiple diseases in an individual, is an increasing global health concern, posing substantial challenges to healthcare systems. Comprehensive understanding of disease-disease interactions and intrinsic mechanisms behind multimorbidity can offer opportunities for innovative prevention strategies, targeted interventions, and personalized trea…
Studies of disease incidence have identified thousands of genetic loci associated with complex traits. However, many diseases occur in combinations that can point to systemic dysregulation of underlying processes that affect multiple traits. We have developed a data-driven method for identifying such multimorbidities from routine healthcare data that combines topic modelling through Bayesian binary non-negative ma…
Open article record in new tab ↗Multimorbidity has been increasing globally and is usually associated with higher health care utilization and costs. Indonesia has been implementing Universal Health Coverage (UHC) program since 2014. However, there is a limited study of the prevalence of multimorbidity and its impact on health care utilization and costs through the UHC scheme in Indonesia. This study aimed to determine the prevalence of multimorb…
Open article record in new tab ↗Introduction Multimorbidity describes the presence of two or more long-term conditions, which can include communicable and non-communicable diseases, and mental disorders. The rising global burden from multimorbidity is well-documented, but trial evidence for effective interventions in low- and middle-income countries (LMICs) is limited. Selection of appropriate outcomes is fundamental to trial design to ensure cr…
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