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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
147 articles
Newest firstObjective Xerostomia (dry mouth) is a common condition that negatively impacts life quality for adults of all ages. Yet, xerostomia has primarily been studied among older adults and populations at high risk of dry mouth, with no widely-available self-reported instrument to assess xerostomia accurately among younger populations. This study aimed to develop a brief xerostomia assessment tool specifically designed fo…
Open article record in new tab ↗Rationale Traumatically injured individuals can develop chronic negative psychological sequelae. Improved understanding of contributing, peri-traumatic risk factors is essential to reduce the risk of these consequences. Previous studies have found that peri-traumatic, circulating endocannabinoid concentrations are positively associated with development of post-traumatic stress disorder (PTSD), chronic pain and dep…
Background Endometriosis affects up to 10% of biological females of reproductive age. Current treatment options are limited and often unsuitable for prolonged use. Cannabis-based medicinal products (CBMPs) have emerged as an alternative for pain management. Aims To analyse changes in patient-reported outcome measures (PrOMs), prescribed opioid burden, and the prevalence of adverse events (AEs) in patients prescrib…
Open article record in new tab ↗Purpose The global burden of chronic health conditions is significant. Medicinal cannabis (MC) is a legalised treatment option for patients with chronic health conditions in some countries. Health-related quality of life (HRQL) is an important patient-reported outcome across all chronic health conditions. We aimed to determine how studies of MC therapy justify, measure, and report HRQL, and assess the current evid…
PurposeTo examine whether measures of health status and quality of life (QoL) were associated with cannabis use after cancer diagnosis.MethodsIndividuals who received care at an NCI-designated cancer center from 2018 to 2019 (n = 5,901) were invited to complete an online survey in 2022, of which 954 responded. We included 652 respondents in this study, which were weighted to represent the cancer center patient pop…
Open article record in new tab ↗Introduction Fibromyalgia is a common condition characterised by widespread chronic pain, associated with comorbid mental health disorders and reduced quality of life. Preclinical data suggest cannabis-based medicinal products (CBMPs) may have potential benefits in fibromyalgia, but there is a paucity of high-quality clinical evidence. This study aims to assess the change in patient-reported outcome measures (PROM…
Background Older adults represent the fastest-growing group of medical marijuana (MM) users in the United States, with chronic pain being the most common reason for use. Despite this trend, scientific evidence remains limited regarding the short- and long-term effects of MM on critical health outcomes, including cognitive function, physical and mental health, and overall quality of life, in this population. To bet…
The endocannabinoid system plays an important role in the modulation of pain, mood, sleep, and subjective wellbeing. Despite the growing clinical use of medicinal Cannabis, real-world data simultaneously evaluating quality of life and sleep-related outcomes in heterogeneous clinical populations remain limited. This study aimed to assess quality of life and sleep satisfaction in patients using medical Cannabis oil…
Background Although there is growing evidence supporting the use of cannabis-based medicinal products (CBMPs) for the management of chronic pain, there is a paucity of data on their effect on endometriosis-associated chronic pain. Aims This study aimed to perform an analysis of pain-specific and general health-related quality of life (HRQoL) outcomes for patients with endometriosis-associated chronic pain treated…
Introduction Anxiety disorders are among the most prevalent and disabling mental health conditions and are associated with impairments in quality of life (QoL). Previous studies have examined medicinal cannabis for anxiety and QoL using short-term follow-up or cross-sectional surveys. However, there is little longitudinal qualitative research examining how patients experience QoL changes. Aim To explore the percei…
BackgroundUterine fibroids cause significant morbidity, psychosocial stress, and poor quality of life due to symptoms including heavy menstrual bleeding, anemia, pain, and bulk symptoms, as well as reproductive complications including infertility, early pregnancy loss, and preterm birth. Fibroids represent a 42.2 billion USD annual economic burden to the United States healthcare system. Despite reported delays in…
Background In recent years, a significant number of researchers have concentrated on bioactive compounds for the treatment of neuropathic pain. However, there remains a lack of compelling evidence to robustly support their therapeutic efficacy. Objective This study aims to assess the impact of various bioactive compounds on pain intensity and quality of life in patients suffering from neuropathic pain by conductin…
Open article record in new tab ↗Background A third of epilepsy patients fail to enter seizure remission despite optimal therapeutic management. Cannabis-based medicinal products (CBMPs) have shown promise as a potential therapy. However, a paucity of high-quality literature regarding CBMPs' efficacy and safety profile means further investigation is needed. The study aimed to examine changes in epilepsy-specific and general health-related quality…
Open article record in new tab ↗Objective Human sleep is fundamental for the proper occurrence of organic functions. Hence, lack of sleep can impair cognitive function, resulting in emotional problems, memory changes, and disease onset. However, it is worth noting that sleep is influenced by outside factors, such as drug use. In this sense, the aim of this review is to analyze studies that researched the influence of recreational marijuana on th…
Open article record in new tab ↗Background: Insomnia and excessive sleepiness are significant health problems with a complex etiology, increasingly affecting young people, especially students. This study aimed to assess the prevalence of sleep disturbances and patterns of psychoactive drug use among female Polish students. We also explored the potential impact of the COVID-19 pandemic on sleep behaviors. We hypothesized that sleep disorders are…
Open article record in new tab ↗The aim of this study was to assess changes in validated patient-reported outcome measures after initiation of cannabis-based medicinal products (CBMPs) and the safety of CBMPs in patients with inflammatory arthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. The primary outcomes changes were in Brief Pain Inventory, McGill Pain Questionnaire, EuroQol 5-dimension 5-level (EQ-5D-…
The endocannabinoid system has been implicated in the pathophysiology of multiple sclerosis (MS), yet its role across different disease stages and under disease-modifying treatment remains incompletely understood. This study aimed to evaluate plasma levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in patients with MS at different clinical stages, and to explore their associations with disability, cogni…
Background Energy drink (ED) use is common among young adults and adult populations and may be linked to poorer quality of life (QoL). This study examined the prevalence of ED consumption and its association with QoL in Spanish adults. Method A cross-sectional design was used with a sample of 1,146 participants aged 18 to 54 years, recruited by convenience sampling through university mailing lists and social media…
Open article record in new tab ↗[This corrects the article DOI: 10.3389/fphar.2025.1539704.].
Open article record in new tab ↗Background and Objectives: The worldwide shift toward psychiatric deinstitutionalization has aimed to enhance patient autonomy, social integration, and overall quality of life. However, limited studies have examined how concurrent substance use-particularly alcohol, marijuana, and inhalable drugs-affects clinical outcomes in these populations. This study aimed to evaluate psychiatric patients with varying degrees…
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