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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
120 articles
Newest firstPurpose Nicotine and cannabis are commonly co-used among adolescents and young adults (AYAs). Same session co-use has more negative effects than co-use that does not overlap. Little is known about how or why these products are used within the same session. Enhanced understanding of this behavior pattern can be leveraged to reduce co-use in this population. Methods Connecticut AYAs (15-20 years old) who self-report…
Open article record in new tab ↗Background and aims Substance use in sports, though harmful, is common but with little evidence from Africa. This study aims to assess the prevalence and self-reported motivations for substance use, as well as to characterize the patterns of alcohol, tobacco, and cannabis use among professional footballers in Accra. Methods This cross-sectional study included 139 professional footballers from nine teams competing…
Open article record in new tab ↗Background Marijuana use is rising in the United States, yet its impact on perioperative outcomes remains poorly understood, particularly in orthopaedic trauma where cessation is often not feasible. This study evaluates the risks associated with cannabis and nicotine use in patients undergoing fixation of upper extremity fractures. Methods We performed a retrospective analysis of adult trauma patients with upper e…
Background Most substance users are polysubstance users; however, little is known about how the combined use of different drugs affects the course of substance use disorder or effectiveness of treatment. Notably, co-use of cannabis and nicotine is very common, and we previously demonstrated that nicotine enhances the self-administration of a synthetic cannabinoid receptor agonist and the primary psychoactive phyto…
Cannabis use is rapidly increasing in the United States, yet its perioperative implications remain poorly understood, particularly in trauma populations. Despite expanding legalization, the perioperative effects of cannabis on surgical outcomes remain uncertain. This retrospective cohort study used electronic health record data to evaluate the association between cannabis use, with and without concurrent nicotine…
Background Neurodevelopmental models regard impulsivity as a central risk factor for adolescent substance use. However, the practical utility of impulsivity in predicting substance use is complicated by variability among measures that encompass multiple methods and theoretical domains. Prior research has been constrained by cross-sectional designs, small sample sizes, and/or the use of a narrow subset of impulsivi…
Open article record in new tab ↗AbstractObjectiveCannabis–nicotine co-use is common and may affect cessation outcomes, yet whether recent cannabis exposure alters nicotine’s acute effects in humans remains unclear. We examined whether recent, non-daily cannabis exposure modulates the acute subjective effects of intravenous (IV) nicotine.MethodsWe pooled data from 2 randomized, double-blind, placebo-controlled studies using IV nicotine to isolate…
Open article record in new tab ↗Background Social media influencers who promote e-cigarettes on Instagram or TikTok for tobacco brands use marketing tactics to increase the appeal of their promotional content, for example, depicting e-cigarettes alongside healthy lifestyle or entertainment imagery that could decrease youths' risk perceptions of e-cigarettes. Monitoring the prevalence of such content on social media using computer vision and gene…
IntroductionAdults with attention-deficit/hyperactivity disorder (ADHD) use tobacco, cannabis, alcohol, cocaine and non-prescribed stimulants far more than the general population. The self-medication hypothesis holds that people with ADHD, including those undiagnosed, use substances to relieve core symptoms rather than for recreation or shared vulnerability to addiction, and is widely invoked to reframe illicit su…
Open article record in new tab ↗Background Alcohol-induced blackouts (AIBs) are a serious consequence of alcohol use that are strongly associated with experiencing excess alcohol-related harms. AIBs are common and recurrent among young adults who drink. The risk factors for AIBs include dynamics of alcohol use (quantity, speed, duration), alcohol-related behaviors (eg, playing drinking games, not using protective behavioral strategies), and fact…
BackgroundFollowing Germany’s partial cannabis legalization in April 2024, evidence on adolescent cannabis use risk factors is needed. Social media platforms represent understudied risk environments, and the comparative predictive value of risk perception versus prevention remains unclear. This study aimed to examine determinants of adolescent cannabis use in Germany, including platform-specific social media effec…
Background Emergency medical service (EMS) clinicians are first responders who can experience work-related stressors. Substances can be used as a coping strategy to manage stress. The ability to self-regulate motivation, cognition, and emotions may protect against substance use. Our objective was to examine the associations among stress, self-regulation, and substance use in EMS clinicians to identify potential ps…
BackgroundSubstance use initiation in adolescence is influenced by both genetic and environmental factors; however, large-scale genetic studies often treat initiation as a binary outcome and underuse longitudinal timing information. MethodsWe conducted time-to-event (survival) genome-wide association analyses (GWAS) of initiation for four outcomes--alcohol, nicotine, cannabis, and any substance use--using longitud…
Open article record in new tab ↗Introduction:Perinatal intimate partner violence (IPV) and perinatal cannabis and nicotine product use are common and associated with negative maternal–infant health outcomes. Substance use coercion (SUC), which involves abusive partners’ controlling behaviors related to substance use, has not been studied for cannabis and nicotine products. Perinatal individuals may be particularly vulnerable to SUC, and this stu…
Background Inhaled combusted cannabis and co-use of combusted cannabis and nicotine electronic cigarettes (ECIGs) are emerging trends among young adults, yet the potential cardiovascular disease risks associated with these substances remain unclear. This study examined whether cannabis use increases cardiovascular disease risk, specifically, arrhythmia risk, as estimated by ventricular repolarization, and whether…
Adolescent e-cigarette and cannabis vaping have become significant public health concerns, with rates increasing in recent years. However, there is limited research on the impacts of COVID-related stress on adolescent vaping. This study examined the longitudinal impacts of COVID-related stress on adolescent e-cigarette and cannabis vaping, including the mediating role of vaping susceptibility (which measures a lac…
Background:Approximately 30 % of people who use tobacco also use cannabis, and rates of co-use are rising. Relative to people who use tobacco alone (TO), individuals who co-use tobacco and cannabis (TC) experience greater difficulty with tobacco cessation, yet mechanisms underlying this phenomenon remain unexplored. Leveraging data from a multi-site, double-blind clinical trial for tobacco cessation, we compared t…
Open article record in new tab ↗Introduction Preterm delivery is an obstetric complication linked to an increased risk of postpartum depression (PPD), which often goes undiagnosed. Individuals with PPD may self-medicate to manage depressive symptoms. While postpartum substance use is well-documented, few studies have assessed whether preterm delivery is associated with new-onset substance use. A greater understanding of birth trauma as a factor…
Open article record in new tab ↗Background/Objectives: There is limited research on vaping during pregnancy and the postpartum period. Amid the legalization of cannabis in Canada, and evolving patterns of nicotine use, there is a growing need to understand how women experience using nicotine and cannabis vaping during pregnancy and postpartum. This information is essential to inform both women and healthcare providers (HCPs) and to develop resou…
Open article record in new tab ↗The aims of this study were to examine associations between psychological inflexibility and (1) cigarette dependence among individuals who co-use cannabis and combustible cigarettes, and (2) binge drinking among individuals who co-use cannabis and alcohol. Adults attending a medical marijuana dispensary (N = 697) completed a survey examining cannabis use, cigarette smoking, binge drinking, psychological inflexibil…