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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
68 articles
Newest firstIntroduction Cannabis use during adolescence and young adulthood has been associated with neurocognitive alterations. However, limited attention has been paid to whether these findings vary according to developmental stage and regional context. This systematic review examined the neurocognitive effects of cannabis use in adolescents and young adults, with particular attention to age-related patterns and geographic…
Open article record in new tab ↗Introduction Evidence suggests an association between chronic psychoactive substance use and memory deterioration. Autobiographical memory (AM) is one form of long-term memory that is captured through specific personal information. Exploring potential causes of AM impairment is crucial as these memories shape identity and are important for problem solving and imagining the future. This is the first systematic revi…
Open article record in new tab ↗Introduction Preparations of Cannabis sativa have been used for medicinal purposes for many centuries Currently, it is known that the phytocannabinoids present in the Cannabis sativa plant can modulate the endocannabinoid system, producing a variety of effects. Among the most abundant phytocannabinoids are delta-9-tetrahydrocannabinol (19-THC) and cannabidiol (CBD). CBD lacks psychotropic properties and has been s…
Open article record in new tab ↗Background and hypothesis Cannabis use initiation during adolescence has increased globally, raising concerns about neurodevelopmental consequences during this critical period when the brain undergoes extensive remodeling in cannabinoid receptor-rich regions. Study design This systematic review examines neurodevelopmental consequences of adolescent cannabis use, focusing on structural brain changes, cognitive impa…
Open article record in new tab ↗AbstractRationaleElectronic cigarettes (EC) are handheld electronic vaping devices that produce an aerosol by heating a liquid. People who smoke, healthcare providers, and regulators want to know if EC can help people quit smoking, and if they are safe to use for this purpose. This update was conducted as part of a living systematic review.ObjectivesTo examine the safety, tolerability, and effectiveness of EC for…
Open article record in new tab ↗Background In recent years, a significant number of researchers have concentrated on bioactive compounds for the treatment of neuropathic pain. However, there remains a lack of compelling evidence to robustly support their therapeutic efficacy. Objective This study aims to assess the impact of various bioactive compounds on pain intensity and quality of life in patients suffering from neuropathic pain by conductin…
Open article record in new tab ↗Objective Cannabinoids, present in Cannabis sativa, modulate the signaling and receptor expression of the endocannabinoid system (ECS), potentially impacting various skin conditions. However, current evaluations of their clinical effectiveness remain largely descriptive. This study aimed to quantitatively assess the effectiveness of cannabinoids, including Cannabis sativa extracts, in treating dermatologic disorde…
Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of medical cannabis on adults with insomnia.
Open article record in new tab ↗Objective This study aimed to evaluate the efficacy and safety of antiepileptic drugs and non-pharmacological treatments in patients with Lennox-Gastaut syndrome (LGS). Methods We conducted a systematic search of the PubMed, Embase, Cochrane, and Web of Science databases for randomized controlled trials (RCTs) evaluating both pharmacological and non-pharmacological interventions for LGS. The treatments assessed in…
Open article record in new tab ↗Background Ischemic stroke is an acute neurological disorder with limited treatment options. Medical cannabinoids (MCs), primary bioactive compounds extracted from cannabis plants, have shown therapeutic prospects for ischemic stroke. This study integrates bibliometrics and meta-analysis to comprehensively summarize the research landscape of MCs in cerebral ischemia and thoroughly investigate their role and potent…
Open article record in new tab ↗Overview Cannabinoids have gained increasing attention for their therapeutic potential in treating several neurological conditions, including neurodegenerative diseases, chronic pain, and epilepsy. This review aims to assess the current clinical trials investigating cannabinoids, primarily Tetrahydrocannabinol and Cannabidiol, for neurological disorders. This review will aim to highlight the efficacy, safety, and…
Open article record in new tab ↗Introduction Substance abuse and behavioral addictions among adolescents represent a growing public health concern, with significant implications for their physical, mental, and social development. This systematic review aimed to identify the most commonly used substances and prevalent addictive behaviors in this population. Methods A comprehensive search was conducted across multiple scientific databases to selec…
Background Growing bodies of evidence suggest that cannabis may play a significant role in both oncological palliative care and as a direct anticarcinogenic agent, but classification as a Schedule I substance has complicated research into its therapeutic potential, leaving the state of research scattered and heterogeneous. This meta-analysis was conducted to determine the scientific consensus on medical cannabis'…
Open article record in new tab ↗Essential oils have emerged as popular natural alternatives to synthetic ingredients in cosmetic products, drawing attention for their therapeutic potential in treating skin conditions like acne, psoriasis, and atopic dermatitis. This systematic review analyzed 70 studies from the past decade across multiple databases to evaluate their effectiveness and safety in derma cosmetic applications. The research encompass…
Open article record in new tab ↗Rationale Electronic cigarettes (EC) are handheld electronic vaping devices that produce an aerosol by heating a liquid. People who smoke, healthcare providers, and regulators want to know if EC can help people quit smoking, and if they are safe to use for this purpose. This review update was conducted as part of a living systematic review. Objectives To examine the safety, tolerability, and effectiveness of EC fo…
Background The occurrence of stroke in young people has risen significantly. This can easily lead to physical disabilities, swallowing difficulties, and cognitive impairment, among other issues, having a profound impact on families and society. Risk factors for stroke in young people differ from those for traditional stroke, with cannabis abuse emerging as a significant high-risk factor. However, the extent of the…
Open article record in new tab ↗Aim To evaluate the comparative efficacy and safety of various doses of oral cannabidiol (CBD) in treating refractory epilepsy indications, thus providing more informative evidence for clinical decision-making. Methods A literature search of PubMed, Embase, the Cochrane library, and Web of Science (WoS) was performed to retrieve relevant randomized controlled trials (RCTs) that compared different doses of oral CBD…
Open article record in new tab ↗Background Methylphenidate (MPH), a central nervous system stimulant primarily prescribed for attention-deficit/hyperactivity disorder (ADHD), has seen increasing rates of misuse and abuse, particularly in patients with dual diagnosis (co-occurring psychiatric disorders and substance use disorders/SUDs). The heightened risk of dependence and adverse effects in these vulnerable populations warrants a systematic rev…
Background Problematic cannabis use is highly prevalent among people with mood disorders. This underscores the need to understand the effects of cannabis and cannabinoids in this population, especially considering legalization of recreational cannabis use. Objectives We aimed to (1) systematically evaluate cross-sectional and longitudinal studies investigating the interplay between cannabis use, cannabis use disor…
Open article record in new tab ↗Background The use of substances such as alcohol, tobacco, khat, or drugs among young people is becoming a public health concern globally, with particularly high prevalence rates in low and middle-income settings, where socio-cultural and economic factors contribute to distinct challenges in addressing this problem. This review aimed to summarize the current literature on the prevalence of substance use among youn…
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