Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
88 articles
Newest firstINTRODUCTION: Preoperative substance use is increasingly observed among candidates for metabolic and bariatric surgery (MBS), yet its perioperative and 1-year effects remain unclear in the Middle East and North Africa (MENA). We assessed whether routine preoperative urine toxicology screening tests (TSTs) predict anesthetic requirements, recovery, early complications, and 1-year weight loss. METHODS: Prospective s…
Open article record in new tab ↗Background Marijuana initiation among adults aged 50 years and older has increased substantially. Although acute tetrahydrocannabinol exposure can impair psychomotor function, less is known about how real-world medical marijuana initiation relates to functional tasks such as driving in mid-to-late life. Objective The objective of our study was to evaluate the feasibility of recruiting and retaining adults aged 50…
Aims To estimate the prevalence of prenatal cannabis use in Michigan, USA, using self-reports and urine toxicology and to examine factors associated with use. Design Observational study using data from the Michigan Archive for Research on Child Health (MARCH) cohort, part of the National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) program. It is a prospective statewide pregnancy…
Background/Objectives: Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, microvascular dysfunction, and low-grade inflammation. Although low-carbohydrate, high-fat (LCHF) dietary approaches are increasingly used in clinical practice, their longer-term associations with vascular, lymphatic, and immunometabolic pathways in lipedema remain insufficiently understoo…
Objective: The use of recreational drugs such as alcohol and tetrahydrocannabinol(THC) is increasing worldwide. While tobacco and certain illicit substances are well-established risk factors for aneurysmal subarachnoid hemorrhage (aSAH), the role of alcohol and THC remains less well defined. Understanding their potential impact on aneurysm rupture and clinical severity could have significant implications for preve…
Background Older adults represent the fastest-growing group of medical marijuana (MM) users in the United States, with chronic pain being the most common reason for use. Despite this trend, scientific evidence remains limited regarding the short- and long-term effects of MM on critical health outcomes, including cognitive function, physical and mental health, and overall quality of life, in this population. To bet…
Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity. This study aimed to develop a practical risk score for SCRAs prevalent in Germany between 2013 and 2021, based on prevalence data and differentiated data on intox…
Background and aims The impact of exposure to cannabis dispensaries on young adult cannabis use may depend on how exposures and outcomes are defined. We estimated associations of dispensary exposure with young adult cannabis use across: (a) a government-maintained licensed dispensaries registry versus a web-scraped list of licensed and unlicensed dispensaries; and (b) varying modes of cannabis modes (i.e. smoked,…
Background and objectives Cannabis consumption is increasing in both the recreational and medical settings. Tetrahydrocannabinol (THC) is known to produce cardiovascular effects, but the specific roles of THC and its metabolites THC-OH and THC-COOH in cannabinoid-induced cardiovascular effects remain unclear. We hypothesized that THC and THC-OH mediate a cannabinoid-induced increase in heart rate in either an addi…
Introduction Many states have legalized the use of cannabis for medical or recreational purposes. Cannabis is commonly used both recreationally and medicinally, with therapeutic applications for conditions including chronic pain, seizure disorders, multiple sclerosis, anxiety, and depression. The purpose of this study was to compare emergency department (ED) patient knowledge of the short- and long-term effects of…
Adolescent e-cigarette and cannabis vaping have become significant public health concerns, with rates increasing in recent years. However, there is limited research on the impacts of COVID-related stress on adolescent vaping. This study examined the longitudinal impacts of COVID-related stress on adolescent e-cigarette and cannabis vaping, including the mediating role of vaping susceptibility (which measures a lac…
Background Adolescence is a key developmental period associated with an increased risk of experiencing cannabis-related problems. Identifying modifiable risk factors prior to the onset of cannabis use could help inform preventative interventions. Method Analysis nested within a UK prospective birth cohort study, the Avon Longitudinal Study of Parents and Children. Participants (n = 6,049) provided data on cannabis…
Open article record in new tab ↗Aim The environment shapes the risk of psychosis. In particular, urbanicity, deprivation or inequality, migrant density and cannabis availability may not only influence psychosis incidence, but also the characteristics of individuals who arrive at clinical services. This study examined how socioeconomic factors influence the incidence and characteristics of cases of First-Episode Psychosis (FEP). Methods We analys…
Objectives Rapid growth in the cannabidiol (CBD) market has been temporally associated with increasing emergency department (ED) visits related to cannabis exposure in young children. This study examined the prevalence of CBD products among individuals with and without children in the household and described their general perceptions of CBD products to assess potential risks to children. Methods A prospective obse…
Open article record in new tab ↗Background The co-occurrence of cannabis use and internalizing symptoms, such as depression and anxiety, during emerging adulthood (18-25 years) is well documented. However, while bidirectional relationships are often assumed, empirical evidence is mixed. This study investigates bidirectional longitudinal relationships between cannabis frequency and consequences and internalizing symptoms (depressive and anxiety)…
Most adolescents and young adult victims of firearm violence survive, yet the mental and behavioral health outcomes associated with these incidents remain understudied. Given the potential for recurrent violence victimization and long-term psychosocial sequela after being shot, understanding the experiences of firearm injury survivors is a critical area for development. We conducted a qualitative study to explore…
The aim of this study was to assess changes in validated patient-reported outcome measures after initiation of cannabis-based medicinal products (CBMPs) and the safety of CBMPs in patients with inflammatory arthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. The primary outcomes changes were in Brief Pain Inventory, McGill Pain Questionnaire, EuroQol 5-dimension 5-level (EQ-5D-…
Introduction Elderly patients with common bile duct (CBD) stones often present with large or multiple stones, making endoscopic retrograde cholangiopancreatography (ERCP)-guided extraction a technically complex and potentially high-risk procedure. Aim This study aimed to compare the efficacy and safety of a staged approach-biliary stenting followed by delayed stone extraction-versus immediate stone removal during…
Adolescent substance use can have a significant negative impact on life trajectories. Therefore, identifying factors associated with adolescent substance use is important. Previous research has identified parental religiosity as a factor associated with lower adolescent substance use. However, these studies suffered from a number of limitations and are often focussed on US samples, which limit the generalisability…
Open article record in new tab ↗Background Postpartum depression (PPD) rates in the United States are among the highest globally, and PPD can pose significant, long-term risks to families. Concurrently, perinatal cannabis use is increasing in prevalence and may exacerbate PPD. Although evidence links cannabis use with PPD, little is known about its impact on immediate depressive symptoms or depression trajectories across the perinatal period. Mo…