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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
71 articles
Newest firstPain and sleep disturbances are primary reasons for medicinal cannabis use. Cannabis influences both pain and sleep through its modulation of the endocannabinoid system, which regulates pain and sleep signaling. Despite their interconnected roles, the effects of cannabis and chronic pain on sleep architecture have been studied mainly in isolation. An integrated understanding is needed to guide use and minimize ris…
Open article record in new tab ↗Introduction Individuals with substance use disorders (SUDs) are at increased risk for sleep disturbances, creating a bidirectional relationship that may heighten relapse risk. While polysomnography is the gold standard for measuring sleep, many studies have used actigraphy, a noninvasive, wrist-worn device that estimates rest-activity patterns and sleep-wake characteristics. Despite its utility, the use of actigr…
Objectives Cannabis is often used alongside other substances, including cigarettes and alcohol. The objective of this study was to identify how the combination of these substances may affect sleep health. Methods Data from an online, national survey of 518 adults (35.2 ± 13.4 years old; 65% female) were analyzed. Respondents reported their cannabis, cigarette, and alcohol use. Hazardous cannabis use was assessed u…
Open article record in new tab ↗Background Despite limited research, cancer patients are opting for compounds found in cannabis, like tetrahydrocannabinol (THC) and cannabidiol (CBD), to improve their sleep. The purpose of this study was to examine the therapeutic value of cannabis for sleep. Methods Patient-reported symptom responses were obtained from 1962 cancer patients enrolled in the Minnesota Medical Cannabis Program (MMCP) from 2015 to 2…
Open article record in new tab ↗Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and behavioral disturbances. While its pathogenesis is complex, increasing evidence supports the role of an imbalance between excitatory and inhibitory (E/I) neuronal activity in disease progression. E/I imbalance contributes to synaptic impairment, network hypersynchrony, and ultimately cogn…
Background Alcohol-induced blackouts (AIBs) are a serious consequence of alcohol use that are strongly associated with experiencing excess alcohol-related harms. AIBs are common and recurrent among young adults who drink. The risk factors for AIBs include dynamics of alcohol use (quantity, speed, duration), alcohol-related behaviors (eg, playing drinking games, not using protective behavioral strategies), and fact…
Study objectives Cannabis is widely self-administered as a sleep aid, yet objective evidence from large polysomnography cohorts remains scarce. We assessed whether long-term daily cannabis use is associated with alterations in overnight sleep architecture at a Canadian sleep clinic. Methods We retrospectively analyzed overnight polysomnography studies from 1449 adult sleep clinic patients. Exposure was chronic can…
Open article record in new tab ↗Background Sleep-promotion is one of the most common reasons people use cannabis. Previous studies, primarily among young adults, suggest that cannabis use has negligible day-level effects on sleep but may attenuate alcohol's negative effects when both substances are used. Studies among middle-aged/older adults are needed to determine the generalizability of these day-level associations. Methods This preregistered…
Open article record in new tab ↗Medicinal cannabis is being used worldwide and there is increasing use of novel cannabis products in the community. Cannabis contains the major cannabinoids, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), but also an array of minor cannabinoids that have undergone much less pharmacological characterization. Cannabinol (CBN) is a minor cannabinoid used in the community in "isolate' products and is claimed…
Introduction The prevalence of cannabis use among youth is rising globally, making it crucial to understand its role in health and well-being. While cannabis use is linked to various health outcomes, evidence on its relationship with 24-h movement behaviours (moderate-to-vigorous physical activity, sedentary behaviour, and sleep) in youth is limited. This study uses a digital citizen science approach to examine th…
Open article record in new tab ↗Objective Human sleep is fundamental for the proper occurrence of organic functions. Hence, lack of sleep can impair cognitive function, resulting in emotional problems, memory changes, and disease onset. However, it is worth noting that sleep is influenced by outside factors, such as drug use. In this sense, the aim of this review is to analyze studies that researched the influence of recreational marijuana on th…
Open article record in new tab ↗Introduction The global average sleep duration has declined significantly, with substantial health and economic consequences. Given the increasing legalization of cannabis for medical and recreational use, this study examines the association between cannabis access laws and sleep duration in the U.S. Methods A two-way-fixed-effects difference-in-differences regression was used to analyze the impact of medical and…
Open article record in new tab ↗The synergistic role played by multiple lifestyle behaviors on mental health during the transition from adolescence to emerging adulthood has not been extensively studied. This study included 493 participants who self-reported on a range of health behaviors during adolescence and emerging adulthood, and psychological distress and mental wellbeing during emerging adulthood. Latent profile analysis and latent transi…
Open article record in new tab ↗Introduction Cannabidiol (CBD) is a compound in the cannabis plant with psycho-physiological effects that may support athletes' training and recovery. Although not banned by the World Anti-Doping Agency, CBD products may carry a risk of inadvertent anti-doping violations due to contamination with prohibited cannabinoids. The primary objective of this study was to characterize the use, rationale, and perceived bene…
Open article record in new tab ↗Objective: This narrative review aims to analyze physical activity as a central pillar of lifestyle modification in the management of chronic musculoskeletal pain by examining its effects on pain modulation as well as related lifestyle domains, including sleep, stress regulation, dietary habits, and smoking behavior. Methods: A narrative structured review was conducted. We searched MEDLINE/PubMed, Embase, and Coch…
Open article record in new tab ↗Introduction Chronic low back pain (CLBP) affects over half a billion people worldwide. Current pharmacologic treatments, comprising mainly non-steroidal anti-inflammatory drugs and opioids, offer limited efficacy and pose significant risks, warranting the development of tolerable, safe and effective alternatives. Methods This randomized controlled trial on adults with CLBP was designed to confirm the superior eff…
Background and objectives Cannabinoid treatments are commonly used for sleep conditions, but the direct sedating effects of daytime treatment consumption and indirect effects on night-time sleep are unclear. This study measures the direct effects of low-dose cannabinoid treatments on daytime sleepiness and potential indirect night-time sleep effects in healthy adult, novice cannabis users. Methods Using a double-b…
Background and aims Conduct a pilot randomized double-blind placebo-controlled crossover trial for adults with subthreshold insomnia symptoms to examine the effectiveness of a cannabinoids supplement on sleep quality and health outcomes. Methods Adults with subthreshold insomnia symptoms (N = 20, Mage = 47.40) were randomized to either the Cannabinoids Supplement (CS) or Placebo Condition (PC) for 10 days. The CS…
Open article record in new tab ↗Objective: The aim of this study is to determine if protein intake, diet quality, or engagement in physical activity mediate the relationship between sleep quality or duration and handgrip strength. Methods: The sample consisted of 2171 middle-aged persons examined in the 2013-2017 Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) prospective cohort study. Those with sleep apnea (n = 222) a…
Open article record in new tab ↗IntroductionIndoor temperature extremes contribute to thermal discomfort and can threaten sleep health. Few studies have investigated indoor temperature-sleep associations, especially across differentially-exposed sociodemographic groups. MethodsUsing cross-sectional Sister Study data (2017-2019), we estimated associations between perceived sleep-disrupting indoor temperature extremes (SDITE) and sleep dimensions.…
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