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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
66 articles
Newest firstGrowing evidence shows that brain aging is a time-dependent process, with very complex underlying mechanisms at molecular and cellular levels. The endocannabinoid system has emerged as a key regulator of brain homeostasis during aging, interfacing with neuroinflammation, neurogenesis, and blood-brain barrier integrity. However, the neurological impact of exogenous cannabinoids in the aging brain remains incomplete…
Open article record in new tab ↗PURPOSE: Cannabis use is increasing among older adults. Given reported associations between delta-9-tetrahydrocannabinol (THC) and increased acute heart rate, there is concern regarding the impact of cannabis on cardiovascular health in older adults. Engaging in regular physical activity (PA) is associated with reduced heart rate and cardiovascular disease risk, but it has yet to be explored whether PA status infl…
Open article record in new tab ↗BACKGROUND: With expanding U.S. cannabis legalization, clarifying its health impacts is critical. This study explores the association between cannabis use frequency and serum Klotho—a biomarker of aging and metabolic health. METHODS: We analyzed 5,827 adults aged 40–59 years from National Health and Nutrition Examination Survey (NHANES) 2007–2016. Cannabis use was self-reported by Computer Assisted Self Interview…
Open article record in new tab ↗Cannabidiol (CBD) effects on bone metabolism in postmenopausal osteoporosis remain unclear. While endocannabinoids and phytocannabinoids bind to receptors in bone cells, direct evidence of CBD's bone-protective effects is lacking. We evaluated the effects of CBD on bone metabolism in ovariectomized (OVX) rat model of estrogen deficiency. Twelve-week study with treatment initiated 2 wk after the surgery was conduct…
Open article record in new tab ↗The crosstalk between the endocannabinoid system (ECS) and reactive nitrogen species (RNS) has emerged as an important area of investigation in recent years. Although many aspects of this interaction remain elusive, accumulating evidence demonstrates that the ECS plays a critical role in regulating RNS-mediated signaling under physiological conditions. This modulation can be either inhibitory or stimulatory, depen…
Background: Magnetic resonance cholangiopancreatography (MRCP) enables non-invasive assessment of biliary lithiasis, duct caliber, and associated anatomical findings. Although age-dependent reference limits for common bile duct (CBD) diameter have been described, the relationships among age, gallbladder stone morphology, ductal anatomy, and CBD stones remain incompletely characterized in consecutive radiology coho…
This study addresses key gaps in our understanding of the cognitive changes associated with normal brain aging and their underlying structural and functional correlates. Declining levels of brain endocannabinoids (eCB), particularly 2-arachidonoylglycerol (2-AG), are thought to contribute to age-related cognitive impairment, but the mechanisms involved remain poorly understood. Here, we show that levels of 2-AG an…
AimTo systematically review all population-based studies reporting the prevalence or incidence of neurodegenerative diseases among adults aged 50 and older in Russia. Subject and MethodsWe systematically searched Medline, Scopus, Embase, and eLibrary from inception to January 2025. The search included peer-reviewed articles, grey literature, and citation checking. Cross-sectional and cohort studies were eligible i…
Open article record in new tab ↗Aging naturally involves a decline in biological functions, often triggering a disequilibrium of physiological processes. A common outcome is the altered response exerted by the immune system to counteract infections, known as immunosenescence, which has been recognized as a primary cause, among others, of the so-called long-COVID syndrome. Moreover, the uncontrolled immunoreaction leads to a state of subacute, ch…
Cannabidiol (CBD) is a non-psychotropic compound found in plants of the Cannabis genus, extensively studied for its therapeutic potential. Research has shown that CBD possesses anti-inflammatory, antioxidant, and regenerative properties, and may contribute to the recovery of neural and bone tissues. In light of the aging population and the resulting rise in neurodegenerative and osteodegenerative conditions, explo…
Background Aging is a multifaceted process marked by the progressive accumulation of cellular damage in various tissues, resulting in a decline in physiological functions. The primary aim of aging research is to identify compounds that can delay or mitigate these detrimental changes. As cannabis legalization becomes more widespread and with limited empirical studies on its effects in the aging human population, th…
Aging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently, cannabinoids derived from Cannabis sativa have emerged as promising therapeutic compounds with neuroprotective, anti-inflammatory, and cognitive-enhancing properties. Despite their benefits, further research is needed to fully understand their efficacy across various conditions…
Lipid metabolism and lipid-derived signaling together ensure cellular and systemic homeostasis. Their dysregulation causes obesity, type 2 diabetes, cardiovascular disease, NAFLD/MASH, and neurodegeneration throughout life. This review integrates central pathways, such as ACC-FASN-mediated de novo lipogenesis, lipid-droplet lipolysis, and mitochondrial and peroxisomal β-oxidation, and their regulation by insulin-P…
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed…
Age-related cognitive decline and neurodegenerative diseases, such as Alzheimer's disease, represent major global health challenges, particularly with an aging population. Mitochondrial dysfunction appears to play a central role in the pathophysiology of these conditions by driving redox dysregulation and impairing cellular energy metabolism. Despite extensive research, effective therapeutic options remain limited…
As the global population ages, the need for effective interventions to support cognitive health in older adults is growing. Cannabidiol (CBD), a non-intoxicating component of cannabis, has emerged as a potential neuroprotective agent due to its anti-inflammatory, antioxidant, and anxiolytic properties. While preclinical studies show promising effects on hippocampal neurogenesis and cognitive performance, human tri…
Open article record in new tab ↗Background Cannabis is a commonly used psychoactive drug, but its cognitive effects remain unclear, particularly in older adults. This study examined associations between past and present cannabis use and cognitive function among dementia-free older adults. Methods Cross-sectional and longitudinal data were drawn from the UK Biobank, including adults aged ≥60 years. Cannabis use patterns were self-reported, and co…
Open article record in new tab ↗Although substance use is associated with a shortened lifespan, impeded health and accelerated biological ageing, the factors contributing to the associations between substance use and ageing are poorly understood. We used summary statistics from genome-wide association studies (GWAS) to investigate whether substance involvement (N from 28K to 2M)-including alcohol, tobacco, cannabis and opioid use and use disorde…
Few laboratory studies permitting granular analyses of alcohol use on neurobehavioral processes in older adults have been reported. This study, reporting baseline data from an on-going longitudinal project, seeks to address this gap. Toward that end, working memory (WM) processes were targeted using the continuous recognition version of the Mnemonic Similarity Task (MST). Healthy male and female drinkers aged 65-8…
Open article record in new tab ↗Background Prior work has found relationships between childhood social adversity and biomarkers of stress, but knowledge gaps remain. To help address these gaps, we explored associations between social adversity and biomarkers of inflammation (interleukin-1β [IL-1β], IL-6, IL-8, tumor necrosis factor-alpha [TNF-α], and salivary cytokine hierarchical "clusters" based on the three interleukins), neuroendocrine funct…