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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
8 articles
Newest firstBACKGROUND: Major depressive disorder (MDD) is a chronic, recurrent psychiatric illness with challenging management, partly due to the heterogeneity of clinical presentations, unpredictable course and episodes, and variable treatment responses. Cannabis may alleviate depression by promoting glutamate, GABA, and dopamine, but results from previous studies remain controversial or inconsistent. In this study, we aime…
Open article record in new tab ↗IntroductionAcute myocardial infarction (AMI) remains a leading cause of mortality, with the coexistence of other conditions (i.e., multimorbidity) complicating management and outcomes. Currently, healthcare providers see major challenges in consideration of the patient with a multimorbid profile, especially as this is a progressive issue where the temporal evolution of diseases is complex in nature, with a profou…
Background Cannabis is a commonly used psychoactive drug, but its cognitive effects remain unclear, particularly in older adults. This study examined associations between past and present cannabis use and cognitive function among dementia-free older adults. Methods Cross-sectional and longitudinal data were drawn from the UK Biobank, including adults aged ≥60 years. Cannabis use patterns were self-reported, and co…
Open article record in new tab ↗Background The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS) on risk for psychosis. Methods Genome-wide association study summary statistics from the Psychiatric Genomics Consorti…
BackgroundCannabis and tobacco use are consistently associated with major depressive disorder (MDD) in conventional observational studies. However, these substances are often co-used, and the independent causal role of cannabis use in risk of MDD remains unclear. MethodsUnivariable and multivariable MR (MVMR) were used to explore the total and independent causal effects of genetic liability to tobacco use and cann…
Open article record in new tab ↗MotivationMultimorbidity, characterized by the simultaneous occurrence of multiple diseases in an individual, is an increasing global health concern, posing substantial challenges to healthcare systems. Comprehensive understanding of disease-disease interactions and intrinsic mechanisms behind multimorbidity can offer opportunities for innovative prevention strategies, targeted interventions, and personalized trea…
Studies of disease incidence have identified thousands of genetic loci associated with complex traits. However, many diseases occur in combinations that can point to systemic dysregulation of underlying processes that affect multiple traits. We have developed a data-driven method for identifying such multimorbidities from routine healthcare data that combines topic modelling through Bayesian binary non-negative ma…
Open article record in new tab ↗Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5%-10% of the general population, though only a small proportion of individuals develop psychotic disorders such as schizophrenia or bipolar disorder. Studying the genetic aetiology of psychotic experiences in the general population, and its relationship with the genetic aetiology of other disorders, may increase our underst…
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