Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
50 articles
Newest firstThe Benson Complex Figure Test (BCFT) is a neuropsychological tool designed to assess visuospatial construction and visual memory with lower complexity than traditional tests. This study evaluated its ability to differentiate between major dementia subtypes. In a retrospective cross-sectional analysis of 1428 participants from a Greek third-age day center (healthy participants [Controls]; patients diagnosed with A…
Open article record in new tab ↗Background Older adults, particularly those residing in long-term care, experience disproportionate rates of cognitive decline and Alzheimer's disease (AD). While isolated nutrient supplementation has demonstrated limited clinical efficacy, comprehensive whole-food dietary patterns may offer significant neuroprotective benefits through complex nutrient synergy. This systematic review evaluates the efficacy of the…
Open article record in new tab ↗Background The cognitive effects of cannabis use in older adults remain unclear, despite increasing use for medical and recreational purposes in this age group. Objective To investigate associations between cannabis use, cognitive performance and dementia risk in older individuals, using large population cohorts and Mendelian randomisation (MR) to explore potential causal relationships. Methods Observational analy…
Open article record in new tab ↗ObjectivesTo describe secondary mental healthcare utilisation and associated costs among patients diagnosed with dementia or mild cognitive impairment (MCI). DesignRetrospective cohort study using routinely collected electronic health record data. SettingSecondary mental healthcare services within a large NHS mental health provider in South London, UK. ParticipantsAdults aged 18 years or older with a recorded diag…
Open article record in new tab ↗AimTo systematically review all population-based studies reporting the prevalence or incidence of neurodegenerative diseases among adults aged 50 and older in Russia. Subject and MethodsWe systematically searched Medline, Scopus, Embase, and eLibrary from inception to January 2025. The search included peer-reviewed articles, grey literature, and citation checking. Cross-sectional and cohort studies were eligible i…
Open article record in new tab ↗IntroductionThe eligibility of anti-amyloid disease-modifying therapies (DMTs) and their integration into clinical practice in some institutions requires a specific range of Mini-Mental State Examination (MMSE) scores. Reliance on this pencil-and-paper psychometric instrument imposes operational burdens and risks perpetuating health disparities due to the tests known educational and cultural biases. This study eva…
BackgroundDespite national efforts to improve research inclusion, people from underserved communities remain underrepresented in dementia trials. Barriers occur at the point of initial engagement and also within the participation pathway itself, as the structure and burden of early screening procedures can discourage continuation. ACCESS D (Advancing Community Collaboration and Engagement Strategies in Dementia) a…
Background Alzheimer's Disease (ad) patients often experience clinically significant agitation, leading to distress, increased healthcare costs and earlier institutionalisation. Current treatments have limited efficacy and significant side effects. Cannabinoid-based therapies, such as the nabiximols oral spray (Sativex®; 1:1 delta-9-tetrahydrocannabinol and cannabidiol), offer potential alternatives. We aimed to e…
Objective We evaluated performance-based differences in neuropsychological functioning in older adults (age 65+) across the dementia continuum (cognitively intact, mild cognitive impairment, and dementia) according to recent cannabis use (past six months). Method A sample of 540 older adults from a well-characterized observational cohort was included for analysis. Participants completed a standardized questionnair…
Background: The global prevalence of Alzheimer’s disease (AD) has emerged as a paramount concern due to the aging population. The current research examines the effects of six-week high-intensity interval training (HIIT), with and without cannabidiol (CBD) supplementation, on cognitive decline, micro ribonucleic acid (miRNA)-124 expression levels, and the protein expression of beta-site amyloid precursor protein cl…
Background Cognitive impairment is associated with higher total healthcare costs (THC) after accounting for demographic factors and comorbidity burden. Objective Determine the proportion of incremental THC associated with cognitive impairment that is accounted for by functional impairments and frailty. Design Four prospective cohort studies of community-dwelling older adults are linked with each other and Medicare…
Open article record in new tab ↗Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a set of multifactorial conditions that progressively impair memory processing and cognitive function. The study of this pathology is particularly challenging due to its complex etiology, which involves several pathological hallmarks, including amyloid plaque formation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, a…
Alzheimer’s disease (AD) is the leading cause of dementia in the elderly, yet effective therapies remain lacking. Here, we identify monoacylglycerol lipase (MAGL), the principal enzyme that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain, specifically in astrocytes as a promising therapeutic target for AD. APP transgenic (TG) mice with astrocyte-specific MAGL deletion (TG-aKO), but not neur…
Open article record in new tab ↗BackgroundSleep disturbances are common in people living with dementia and negatively affect them and their family carers. Non-pharmacological interventions like DREAMS:START (Dementia Related Manual for Sleep: Strategies for Relatives) offer potential benefits but are not yet implemented widely in NHS practice. AimsTo explore the barriers and facilitators to implementing DREAMS:START in UK NHS dementia services,…
Open article record in new tab ↗BackgroundConsidering rising dementia rates, voice assistants are being investigated to support people with dementia (PWD) and reduce the burden on caregivers (CGs). GRACE, an intervention-delivering voice assistant, provides cognitive support and assistance with daily living for people with early-stage dementia. Initial pilot trials showed promising user experience among healthy adults but required further evalua…
Open article record in new tab ↗AbstractO_ST_ABSPurposeC_ST_ABSPrevalence of chronic brain disorders, including dementia, epilepsy, and psychiatric disorders, is increasing worldwide. This represents a major challenge for future healthcare professionnals, especially in Low- and Middle-Income Countries (LMICs). This study aims to assess the knowledge, attitudes, and practices (KAP) of final-year students in medicine, pharmacy, and nursing special…
Open article record in new tab ↗Artificial intelligence and emerging technologies are driving a transformative shift in society, particularly in the healthcare sector, where they enhance diagnostic accuracy, enable personalized treatment approaches, and improve patient monitoring. This systematic review presents a comprehensive analysis of current AI applications specifically emphasizing on dementia. We also address the primary challenges associ…
Open article record in new tab ↗AimsTo explore which activities are offered to nursing home residents with dementia, what their expected contribution to quality of life is, and who chooses and offers these activities. DesignA cross-sectional survey. MethodsHealthcare professionals, informal caregivers, and volunteers of nursing home residents with dementia were invited to participate via the nationwide networks of the Dutch Alzheimer Association…
Open article record in new tab ↗BackgroundAdvance care planning (ACP) and advance directives (AD) are tools for supporting person-centered decision-making. In dementia care, the progression of cognitive decline, complex family dynamics and variability in healthcare systems pose unique challenges to effective ACP/AD implementation for people with dementia (PWD). MethodsWe conducted a scoping review of the literature related to ACP/AD in dementia…
Open article record in new tab ↗INTRODUCTIONWhile a vast amount of MRI data are collected for healthcare delivery, generating real-world evidence (RWE) in Alzheimers and related diseases (ADRD) research is substantially limited by lack of methods and results showing how routine MRIs can be used for ADRD imaging studies. METHODSWe compared three established ADRD biomarkers (total gray matter, hippocampal and ventricular volumes) in four groups (n…