Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities.

Ana Guijarro, Giulia Allavena, Livia Pisciotta, Alessio Nencioni, Irene Caffa

Aging is a gradual loss of tissue homeostasis that leads to impaired physiological organ functions and constitutes a major risk factor for cancer initiation and progression. Despite advances in anti-tumor therapies, cancer remains the second leading cause of death worldwide. The rising incidence of cancer is intimately associated with increased lifespan and the growing proportion of older adults, with 64% of cance…