Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
101 articles
Newest firstAIMS: This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS-related spasticity. METHODS: Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS-related spasticity were included. Studies published in non-Roman characters and those assessing recreational cannabis use we…
Open article record in new tab ↗BACKGROUND: Interest in cannabis extracts for chronic pain, including osteoarthritis (OA), is growing. This systematic review evaluated the efficacy of cannabis extracts in OA across preclinical and clinical studies. METHODS: A comprehensive literature search was performed using Medline via Ovid, Embase via Ovid, CINAHL, and Cochrane Central Register of Controlled Trials database to identify studies published up t…
Open article record in new tab ↗Cannabis use during pregnancy is increasing worldwide, yet evidence regarding its long-term neurodevelopmental consequences remains heterogeneous and inconclusive. This systematic review aimed to synthesise observational evidence on the association between prenatal cannabis exposure and neurodevelopmental outcomes from birth to adolescence. A systematic search of PubMed/MEDLINE, Web of Science, and PsycINFO was co…
Open article record in new tab ↗Introduction Cannabis is one of the most widely used psychoactive substances and is associated with negative consequences affecting physical and mental health, cognition, quality of life, functional outcomes, employment, and interpersonal relationships. The impact of cannabis use varies between individuals and is not necessarily related to consumption quantity or frequency. This variability underscores the importa…
Background Opioids are the mainstay of cancer-related pain management but are limited by adverse effects and clinical complexity. Cannabinoids have been proposed as adjunctive, opioid-sparing agents, yet their impact on opioid consumption in cancer patients remains uncertain. Methods This systematic review and meta-analysis was conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD4202511759…
Background Epidemiological evidence suggests associations between substance use disorders and risk of stroke, but whether these are due to confounding or are true causal relationships remains uncertain. Aims To meta-analyze the observational evidence on illicit substance use and stroke risk and apply Mendelian randomization (MR) to evaluate potential causal effects of substance dependence on stroke subtypes. Metho…
Open article record in new tab ↗ABSTRACTCutaneous wounds represent a significant health problem due to their high prevalence, functional impact, and effects on quality of life. Cannabidiol (CBD), a non‐psychoactive compound derived from Cannabis sativa , has been investigated for its anti‐inflammatory, antioxidant, and regenerative properties, suggesting potential therapeutic applications in wound healing. To systematically evaluate the availabl…
Background and aims NEET (Not in Employment, Education or Training) youth represent a vulnerable population from a public health perspective, facing multiple health challenges, including elevated substance use. Tobacco and cannabis are the most commonly used psychoactive substances among young people, with early initiation associated with long-term health and social consequences. While evidence suggests associatio…
Open article record in new tab ↗Background Cannabinoids are increasingly discussed as adjuncts in addiction treatment, yet whether they improve clinically meaningful substance use disorder (SUD) outcomes beyond short-term symptom relief is unresolved. We determined whether cannabinoid exposure confers directional efficacy across opioid, alcohol, cocaine, tobacco, and methamphetamine use disorders, distinguishing symptomatic targets from sustaine…
Open article record in new tab ↗Glioma is the most common and lethal primary brain tumor in adults, with glioblastoma (GBM) representing the most aggressive subtype, characterized by diffuse infiltration, resistance to therapy, and a poor prognosis. Despite standard treatments, survival remains only approximately 14 months. Cannabinoids have been increasingly investigated for their therapeutic potential in gliomas, particularly GBM. Although mul…
Open article record in new tab ↗Objective Cannabinoids, present in Cannabis sativa, modulate the signaling and receptor expression of the endocannabinoid system (ECS), potentially impacting various skin conditions. However, current evaluations of their clinical effectiveness remain largely descriptive. This study aimed to quantitatively assess the effectiveness of cannabinoids, including Cannabis sativa extracts, in treating dermatologic disorde…
Background Cannabis is one of the most commonly used drugs globally, although its legal status varies across regions. Public support for its decriminalization has increased, but gaps in our understanding of the health consequences of cannabis use remain, particularly related to its impact on mental health. This article provides an updated systematic review and meta-analysis (previous being Lev-Ran et al., ) lookin…
Open article record in new tab ↗Background Understanding risk factors for violence in people with psychosis can inform risk management and violence prevention. However, much of the evidence comes from cross-sectional studies, and previous reviews require updating. Aims To synthesise evidence from longitudinal studies on risk factors for violence in people with schizophrenia-spectrum disorders, bipolar disorder or other affective psychoses. Metho…
Background: Common bile duct (CBD) treatments are often associated with complications, limiting long-term efficacy. To overcome these issues, polymeric grafts have been suggested as promising alternatives, since they are highly customizable, biocompatible, and may reduce side effects frequency. Methods: A systematic review was conducted, interrogating MEDLINE and Cochrane Library. Next, an in vivo study involved 2…
Introduction Substance abuse and behavioral addictions among adolescents represent a growing public health concern, with significant implications for their physical, mental, and social development. This systematic review aimed to identify the most commonly used substances and prevalent addictive behaviors in this population. Methods A comprehensive search was conducted across multiple scientific databases to selec…
Measures that seek to minimise the health and social consequences of substance use are an integral part of national drug strategies in many European countries. Against the backdrop of a high prevalence of cannabis use in the economically advanced countries, and increasing demand for treatment for cannabis-related problems, a range of harm reduction measures have been implemented by peers, statutory bodies and thir…
Open article record in new tab ↗As a wide group of medicines, the effectiveness and safety of 'medical cannabis' products is likely to vary in relation to product-specific dimensions such as potency, dosage, route of administration, and cannabinoid composition. Systematic reviews can perform a crucial role in analysing and synthesising the outcomes of medical cannabis interventions found in empirical research. We analysed 23 contemporary systema…
Open article record in new tab ↗Cannabis use is highly prevalent in people with schizophrenia and is related to adverse clinical outcomes, including relapse and hospitalization. However, the relationship between cannabis and suicide remains inconclusive. This study aimed to systematically review and meta-analyze the relationship between cannabis use and suicide-related outcomes in people with schizophrenia. A comprehensive search of Medline, Emb…
Open article record in new tab ↗Prenatal exposure to alcohol and tobacco has been associated with child regulatory abilities and problems, but less is known about the associations with cannabis exposure. This review seeks to address this gap primarily focusing on the effects of maternal cannabis use on the child. Thus, we investigate the association between pre- and postnatal cannabis exposure of the child and regulatory abilities and problems,…
Background Reviews on cannabis use have been conducted in high-income countries, but limited data exist in Sub-Saharan Africa. In Nigeria, cannabis use is widespread, but systematic reviews summarizing the available data to generate robust evidence that can facilitate interventions have not been conducted. This systematic review and meta-analysis synthesized results from studies highlighting the patterns, prevalen…
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