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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
167 articles
Newest firstIntroduction The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to pose major health challenges despite effective vaccination efforts. The sustained occurrence of breakthrough infections and emerging variants of the virus highlights the need for additional therapeutic strategies. Given the anti-inflammatory role of the cannabinoid typ…
Open article record in new tab ↗Introduction Neurological post-acute sequelae of COVID-19 (neuroPASC) are associated with persistent cognitive dysfunction and quality-of-life decline. We aimed to identify clinical, behavioral and sociodemographic factors associated with neuroPASC symptom burden two years after COVID-19 among individuals without prior neurological disease. Methods In this prospective, observational study, individuals with neuroPA…
Open article record in new tab ↗Background The COVID-19 pandemic disproportionately affected certain populations, with intimate partner violence (IPV) survivors facing heightened risks of adverse health outcomes. This study examined whether women who experienced IPV during Ontario's COVID-19 lockdowns were more likely to report negative behavioural, psychological, and physiological health outcomes compared to women who did not experience IPV . M…
Background The COVID-19 pandemic disrupted face-to-face alcohol and other drug (AOD) treatment services and prompted greater use of telehealth. This study measured the impact of COVID-19 on outpatient treatment episodes before, during, and after stay-at-home orders were introduced. Methods This observational study used routinely collected data from community-based non-government AOD services in New South Wales (NS…
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells when the spike receptor-binding domain (RBD) engages angiotensin-converting enzyme 2 (ACE2). Cannabinoid scaffolds have recently been reported to bind S1/RBD, block spike-mediated membrane fusion, and modulate host inflammatory pathways, making them attractive candidates for entry inhibition. Here, we applied an integrated computational…
BackgroundThe COVID-19 pandemic was associated with reported disruptions to healthcare delivery and malaria control activities in remote, malaria-endemic indigenous communities with limited access to healthcare. Remote indigenous communities in the Peruvian Amazon may have been especially vulnerable due to interruptions in malaria surveillance, diagnosis, and treatment. We investigated the impact of the COVID-19 p…
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has challenged health care systems worldwide, in certain areas exceeding hospital capacities and human resources. This has underscored the importance of having better tools to predict the outcome of potentially severe respiratory infections such as SARS-CoV-2. Predicting COVID-19 severity may allow physicians to better manage ICU beds and increase the ch…
Open article record in new tab ↗To understand the utility of healthcare facility-level wastewater surveillance (WWS) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is important to correlate wastewater SARS-CoV-2 RNA detection with the number of clinical infections. WWS for SARS-CoV-2 was performed at three skilled nursing facilities (SNFs) over 25 weeks. Electronegative membrane filtration (enMF) and Nanotrap(R) Magnetic Vi…
Open article record in new tab ↗AimsCOVID-19 and influenza continue to impose a substantial burden on the Canadian healthcare system, particularly among adults aged [≥]65 years. This study compared the clinical and economic outcomes of a "Stand-alone" vaccination strategy with separate influenza and COVID-19 vaccines versus a "Combination" strategy incorporating mRNA-1083, an investigational vaccine targeting both infections. MethodsThe study ad…
Open article record in new tab ↗BackgroundWidespread immunity from vaccination and infection has reduced COVID-19 morbidity and mortality, but this immunity varies across the population. Understanding how repeated antigenic exposures influence antibody responses helps to inform future vaccination strategies. MethodsSerum samples collected one and six months after XBB.1.5 vaccination from 25 generally healthy healthcare workers with varying expos…
Background The COVID-19 pandemic and its lockdown measures disrupted daily life globally, potentially impacting substance use and mental health. However, the effects in Morocco, shaped by cultural and social factors, remain underexplored. This study aimed to assess the impact of the COVID-19 lockdown on psychoactive substance use and mental health in Morocco, while identifying key socio-demographic determinants of…
Open article record in new tab ↗Aging naturally involves a decline in biological functions, often triggering a disequilibrium of physiological processes. A common outcome is the altered response exerted by the immune system to counteract infections, known as immunosenescence, which has been recognized as a primary cause, among others, of the so-called long-COVID syndrome. Moreover, the uncontrolled immunoreaction leads to a state of subacute, ch…
Introduction The SARS-CoV-2 pandemic beginning in 2020 led to significant restrictions on social life and mobility, raising concerns about increased substance use across the general population. To investigate whether the pandemic resulted in quantitative or qualitative changes in alcohol and/or drug use in the context of road traffic, a retrospective analysis of toxicological findings was conducted in the city of…
Background: Understanding immune response is essential for preparing for public health crises. COVID-19 vaccination provides robust immunity against SARS-CoV-2, but immunocompromised populations may have weaker immune responses. We assessed SARS-CoV-2 spike (trimer) total IgG/IgM/IgA (total Ig) to investigate immune response to COVID-19 vaccination in people living with HIV (PLWH), considering CD4+ T cell count, v…
Open article record in new tab ↗Background Mental health implications of COVID-19 drug use patterns are still unclear. Methods We used data-driven clustering in a large citizen science cohort recruited agnostically to an interest in drug-use to categorise people according to common patterns of drug use and analysed their mental health symptoms (GAD-7 and PHQ-9 items), from recruitment prior to COVID-19 restrictions in 2020 (N = 242,260) to three…
Open article record in new tab ↗Adolescent e-cigarette and cannabis vaping have become significant public health concerns, with rates increasing in recent years. However, there is limited research on the impacts of COVID-related stress on adolescent vaping. This study examined the longitudinal impacts of COVID-related stress on adolescent e-cigarette and cannabis vaping, including the mediating role of vaping susceptibility (which measures a lac…
For patients hospitalized with COVID-19, delirium is a serious and under-recognized complication, and people experiencing homelessness (PEH) may be at greater risk. This retrospective cohort study compared delirium-associated risk factors and clinical outcomes between PEH and non-PEH. This study used patient records from 154 hospitals discharged from 2020-2021 from the Texas Inpatient Public Use Data file. Study s…
Open article record in new tab ↗Background The COVID-19 pandemic intensified the challenges associated with mental health and substance use (SU), with societal and economic upheavals leading to heightened stress and increased reliance on drugs as a coping mechanism. Centers for Disease Control and Prevention data from June 2020 showed that 13% of Americans used substances more frequently due to pandemic-related stress, accompanied by an 18% rise…
Background This study aims to identify sociodemographic factors associated with cannabis use for chronic pain management before and after COVID-19 was declared a pandemic. Furthermore, it seeks to compare cannabis use patterns in adults with and without chronic pain. Methods We analyzed US-based responses from the COVID-19 Cannabis Health Study, a cross-sectional online survey administered via REDCap between March…
Substance use (SU) and physical activity (PA) among university students changed with the beginning of the COVID-19 pandemic. In this study, we examined factors associated with SU and PA and profiles of these health behaviours in university students in Germany 20 months into the pandemic. A cross-sectional study on student well-being during the COVID 19-pandemic was conducted in October/November 2021 at five German…