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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
314 articles
Newest firstABSTRACTBackground and AimsGiven the rising prevalence of cannabis use as an alternative strategy for managing mental health symptoms, there is a crucial need to understand the determinants of substitution behavior, particularly among midlife women who may experience distinct psychosocial and clinical profiles. This study examined the predictors of cannabis substitution among midlife women by comparing profiles of…
Open article record in new tab ↗Anxiety disorders are associated with impaired inhibitory neurotransmission mediated by γ-aminobutyric acid type A (GABA-A) receptors. Although benzodiazepines remain effective anxiolytics, their clinical utility is limited by sedation, cognitive impairment, tolerance, and dependence, prompting the search for mechanistically distinct GABAergic modulators. Among cannabinoid-related molecules, the strongest evidence…
Introduction The COVID-19 pandemic was associated with high levels of depression and anxiety among pregnant individuals in the UK, as shown previously in the EPPOCH cohort. However, the relationships between these psychological burdens, pandemic-related stressors, and substance use in the prenatal period have not been systematically investigated. Methods To address this gap, we conducted a cross-sectional analysis…
Background Entry to higher education coincides with a period of accelerated psychosocial and brain development. Student need for acceptable and accessible well-being and mental health support is straining university resources. Aims To evaluate the acceptability and impact of a digital mental health literacy course tailored for undergraduates and delivered as an accredited interdisciplinary elective. Method Analyse…
Open article record in new tab ↗Highlights What are the main findings? Anxiety is prevalent in both recreational and medical cannabis users with both groups endorsing clinically significant anxiety levels.Qualitative analyses revealed the anxiolytic and anxiogenic experiences of anxiety extended beyond traditional binary diagnostic categories and supports the use of the Research Domain Criteria (RDoC) framework as a valuable approach for underst…
Open article record in new tab ↗BACKGROUND: 22q11.2 deletion syndrome (22qDS) is a genetic disorder affecting various body systems and associated with behavioral and psychiatric conditions, with no currently approved pharmacological treatments. ZYN002, a transdermal gel containing synthetic cannabidiol, has been demonstrated to be well tolerated, showing potential benefit in related neurodevelopmental disorders. The INSPIRE study evaluated the s…
Substance use disorders (SUDs) remain a major public health concern and contribute substantially to compromised quality of life, mortality, and healthcare burden. In the United States alone, millions of individuals are affected by alcohol use disorder (AUD), tobacco use disorder (TUD), and opioid use disorder (OUD), with many cases complicated by co-existing anxiety and stress-related disorders. Piper methysticum…
Open article record in new tab ↗Background Medical cannabis is now commonly prescribed for a range of chronic health conditions. Many medical cannabis products contain delta-9-tetrahydrocannabinol (THC), the intoxicating component in cannabis, though it is unclear whether these products produce impairment when used as prescribed and at therapeutic doses. With current Australian laws prohibiting driving with any amount of THC in one's system, thi…
Open article record in new tab ↗Purpose of review This scoping review used a five-stage framework to evaluate empirical studies positing anxiety and depression as mechanisms or moderators in associations between cannabis use and sleep. Applicable peer-reviewed studies were identified in Google Scholar and PubMed using relevant search terms (e.g., cannabis, sleep, depression, anxiety). Recent findings Of the 20 articles included, most examined ca…
Open article record in new tab ↗Intolerance of uncertainty is often associated with emerging adult psychopathology, including depression, anxiety, and substance use behaviors. However, positive sibling relationships, which are known to support emerging adult mental health during stressful periods, may mitigate the stress related to uncertainty. Thus, this study investigated the role that sibling relationships may have between uncertainty and psy…
Open article record in new tab ↗ABSTRACTIntroductionAutism spectrum disorder (ASD) is a neurodevelopmental disorder associated with distressed behaviors and psychological challenges. This study aims to evaluate the change in health‐related quality of life (HRQoL), anxiety, and sleep quality in autistic individuals prescribed cannabis‐based medicinal products (CBMPs).MethodThis observational case series analyzed data from the UK Medical Cannabis…
Open article record in new tab ↗Background More severe substance use, defined as higher scores on validated measures of problematic use, is increasing within young adult populations. Substance use has been associated with mild traumatic brain injury (mTBI) and elevated symptoms of depression and anxiety. We aimed to understand the relationship between these factors and sex differences in a university sample. Method 894 university students (372 m…
Open article record in new tab ↗Background/Objectives: Mental and neurological disorders contribute substantially to the global burden of disease, affecting people of all ages and backgrounds. As their prevalence increases with age, their overall impact is expected to grow in the coming decades. Although psychological and pharmacological treatments are available, many patients fail to achieve satisfactory outcomes, underscoring the need for impr…
Background Two-thirds of adults in the United States (U.S.) find recreational and medical cannabis use acceptable. Evidence shows that cannabis use is an effective treatment for pain, and as a harm reducing therapeutic for Substance Use Disorder (SUD). In contrast to most SUD treatment models, some models allow illegal substance use as a harm reduction strategy, which is the case for the SUD treatment program exam…
Previous research has shown medical cannabis (MC) to help reduce anxiety for some individuals, although most studies show trends using cross-sectional designs or conduct secondary analyses of preexisting data. The present study systematically tracked 416 registered MC patients in Florida across 45 days to assess daily shifts in anxiety levels. Using daily recording software, collected data included the frequency o…
ObjectiveAs epidemiological patterns of cannabis use and internalizing problems evolve globally, it is critical to reassess their associations-particularly in the post-legalization and post-pandemic context.MethodsParticipants were assessed in the 2012 Canadian Community Health Survey's Mental Health Component (CCHS-MH; n = 25,113) and 2022 Mental Health and Access to Care Survey (MHACS; n = 9,861), two nationally…
The role of the endocannabinoid system (ECS) in the development of depression and anxiety is being actively studied, with evidence suggesting that elevation of ECS signaling can have anxiolytic and antidepressant properties. The current study explored the therapeutic potential of Oleoyl Serine (OS), an endocannabinoid-like lipid, and HU-910, a synthetic selective Cannabinoid type 2 (CB2) receptors agonist, in depr…
Objective This study examined whether cannabis expectancies mediate the relationship between lifetime cannabis use and symptoms of anxiety or depression among women who screened positive for post-traumatic stress disorder (PTSD). Method A total of 271 women completed an online survey assessing PTSD symptoms, lifetime cannabis use, anxiety and depression symptoms, and cannabis expectancies. Mediation analyses evalu…
Open article record in new tab ↗Background and aims Epidemiologic research suggests that adolescent cannabis use is associated with psychological distress (i.e. depression and anxiety symptoms); however, most studies have relied on 20th-century data, when cannabis was significantly less potent than today. This study aimed to estimate the association between adolescent cannabis use and psychological distress using contemporary population-based da…