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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
218 articles
Newest firstComorbid substance use disorders (SUDs) are common but difficult to study due to the complex, interacting and overlapping mechanisms through which they affect brain networks. Many datasets collected to investigate a specific SUD include participants with comorbid SUDs. Although most studies treat comorbid SUDs as covariates of no interest, these covariates also contain untapped information. This is particularly re…
Open article record in new tab ↗Background Marijuana use is rising in the United States, yet its impact on perioperative outcomes remains poorly understood, particularly in orthopaedic trauma where cessation is often not feasible. This study evaluates the risks associated with cannabis and nicotine use in patients undergoing fixation of upper extremity fractures. Methods We performed a retrospective analysis of adult trauma patients with upper e…
Patients with burn injuries exhibit one of the most intense hypermetabolic responses among critically ill populations, making them highly susceptible to malnutrition-linked to prolonged hospital stays and delayed wound healing. While cannabis is recognized for its appetite-stimulating properties in acute settings, its association with the nutritional demands of burn injuries remains underexplored. A single-institu…
Introduction Adolescent substance use and substance use disorders are significant public health issues. Our goal was to evaluate the association between adolescent substance use, detected via blood alcohol levels and urine drug screens, and trauma-related outcomes at a Level I pediatric trauma center. Most of the literature is focused on adult trauma patients with limited data in the pediatrics. Methods In this re…
Background/objectives Post-cholecystectomy syndrome (PCS) remains diagnostically challenging due to overlapping biliary and non-biliary causes. This study aimed to evaluate whether common bile duct (CBD) diameter measured by MRCP can serve as a practical triage parameter in symptomatic PCS patients and to define a data-supported threshold for predicting clinically relevant biliary pathology. Secondary objectives i…
Open article record in new tab ↗Background With the widespread legalization and rising prevalence of cannabis use, understanding its impact on perioperative outcomes has become clinically critical. Although recent orthopaedic research has examined cannabis-related risks following various procedures, its implications following surgical fixation of ankle fractures remain unexplored. Given the increasing incidence and complexity of ankle fractures,…
Open article record in new tab ↗Background Cannabis use is increasing globally, with a parallel rise in Cannabis Use Disorder (CUD). Chronic pancreatitis (CP), a progressive inflammatory condition, is associated with acute pancreatitis (AP) flares and an elevated risk of pancreatic cancer (PC). Although cannabis is often used for pain management in CP, its impact on PC risk and AP flare frequency is unclear. Methods We conducted a retrospective…
Purposes Chronic pancreatitis (CP), a progressive inflammatory disorder characterized by pancreatic fibrosis and degeneration, often leads to common bile duct (CBD) strictures. However, the optimal management of CBD strictures remains controversial. Methods We retrospectively analyzed 16 patients with CP and CBD strictures who underwent surgery at our institution between January 2007 and December 2024. Clinical ch…
This multicenter retrospective study evaluated the effectiveness and safety of highly purified cannabidiol (CBD) in 22 patients with 15q11.2-q13.1 duplication or deletion syndromes (15q-DDS), including 12 with 15q duplication syndrome (dup15q) and 10 with Angelman syndrome (AS). Median (interquartile range [IQR]) age at CBD initiation was 14.5 (10-22.5) years, with a median (IQR) follow-up of 21 (14-33) months. Al…
Introduction Cannabis use has been associated with delayed gastric emptying and may worsen symptoms in patients with gastroparesis. However, its impact on postoperative outcomes after surgical treatment remains unclear. This study aimed to evaluate postoperative outcomes among patients with and without preoperative cannabis use undergoing surgical intervention for gastroparesis. Methods A retrospective cohort stud…
OBJECTIVES: (1) To compare sociodemographic characteristics, psychopathology, and substance use patterns among women diagnosed with substance use disorder (SUD) who experienced physical abuse (PA), sexual abuse (SA), or both (PSA); (2) to describe ages of onset; (3) to evaluate the impact of PA, SA, and their interaction on clinical outcomes. METHODS: Observational retrospective study with patients from PROMUD (Dr…
BackgroundPregnant patients experiencing incarceration with a history of substance use face complex challenges accessing reproductive health services. Despite research indicating interest in these services, contraception counseling and services are often excluded from routine carceral health services.ObjectivesWe sought to examine the postpartum contraceptive plans and fulfillment of pregnant patients in the North…
Introduction Intravenous (IV) fluids are routinely administered empirically in the emergency department (ED) for patients presenting with stimulant intoxication (eg, cocaine, methamphetamine, synthetic marijuana), although the literature is sparse regarding the benefits and risks of this practice. Our primary objective in this study was to assess whether empiric administration of IV fluids in the ED is associated…
Non-medical use of cannabis (NmC) and/or opioids (NmO) can lead to adverse health effects (AHEs), yet the proportion of these harms attributable to adverse childhood experiences (ACEs) remains unclear. This study estimated the contribution of ACEs to AHEs from NmC and/or NmO among adults aged ≥18 years using 2019-2020 Behavioral Risk Factor Surveillance System data from Arizona and Massachusetts. We conducted a re…
This retrospective cohort study evaluated the tolerability, efficacy, and safety of adjunctive cannabidiol (CBD) therapy in pediatric-onset intractable epilepsy across diverse genetic and nongenetic etiologies. Twenty-nine patients aged 6 to 24 years, treated at Korea University Hospitals between April 2019 and May 2024, were included. The median follow-up duration was 14.3 months. Confirmed genetic etiologies inc…
Open article record in new tab ↗Over the past two decades, fatal workplace accidents have accounted for between 300,000 and 400,000 deaths a year worldwide. The aim of this study was to investigate the general characteristics and the toxicological profile of work-related deaths. A descriptive retrospective study was carried out on occupational-related deaths occurred in the Lyon metropolitan area from 2000 to 2020 from the autopsy reports of the…
Study objectives Cannabis is widely self-administered as a sleep aid, yet objective evidence from large polysomnography cohorts remains scarce. We assessed whether long-term daily cannabis use is associated with alterations in overnight sleep architecture at a Canadian sleep clinic. Methods We retrospectively analyzed overnight polysomnography studies from 1449 adult sleep clinic patients. Exposure was chronic can…
Open article record in new tab ↗Background Cannabis use is rising among adults, yet few users receive structured medical supervision. Older users face unique risks necessitating specialized oversight. Given their longitudinal relationships and detailed understanding of patients' health and goals, primary care providers are well-positioned to guide decisions and education about medical cannabis (MC). Further, because of their expertise in managin…
Open article record in new tab ↗Purpose Intraocular pressure (IOP) is a major clinical marker used to diagnose glaucoma and monitor its treatment. Marijuana use can confound IOP measurements by temporarily lowering the IOP, potentially leading to missed diagnoses of glaucoma or a false sense of effective treatment. Therefore, factors that may affect diagnosis or treatment of glaucoma need to be characterized and considered. We aim to assess the…
Open article record in new tab ↗New psychoactive substances (NPS) are health-hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter. Up to 138 NPS were retrospectively identified using liquid chromatography-high resolution mass spectrometry data from all 34 183 oral fluid drug samples collected in one Swedish health care region 2019-2020 representing 9468 psychiatric and addiction…