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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
7 articles
Newest firstBackground and hypothesis A sex difference in the clinical presentation of schizophrenia is well known. Males have on average an earlier symptom onset, worse functional capacity, and more negative symptoms. Studies on the neurobiological correlates of psychosis show that brain endocannabinoid system (ECS) is dysregulated in male patients with first-episode psychosis (FEP). We now evaluated whether the brain ECS is…
Open article record in new tab ↗Novel psychoactive substances (NPSs) exhibit extremely strong pharmaco-toxicological activity, often leading to severe adverse effects that pose a serious risk to consumers' health. Among these, synthetic cannabinoids (SCs) currently represent the majority of drug seizures in Europe. One such compound, AKB-48 (also known as APINACA), was first identified in Japanese herbal smoking blends in 2012. Although it mimic…
Introduction Recent studies show that young females now report higher e-cigarette use than males, reversing prior trends. While sex differences in use are documented, little is known about underlying risk profiles. This study applied a machine learning (ML) approach to identify and compare predictors of adolescent e-cigarette use by sex. Methods We analyzed cross-sectional data from 1829 9th graders in Southern Ca…
Open article record in new tab ↗Purpose To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents. Method Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental (ch…
BackgroundPeru implemented a nationwide chloroquine/hydroxychloroquine (CQ/HCQ) treatment policy during the early phase of the COVID-19 pandemic. Whether these drugs trigger hemolytic crises in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd), a genetic condition primarily affecting men, with a relatively high prevalence in certain regions, is a matter of debate. This study investigated whethe…
Open article record in new tab ↗Clinical studies provide fundamental knowledge of substance use behaviors (substance of abuse, patterns of use, relapse rates). The combination of neuroimaging approaches reveal correlation between substance use disorder (SUD) and changes in neural structure, function, and neurotransmission. Here, we review these advances, placing special emphasis on sex specific findings from structural neuroimaging studies of th…
Open article record in new tab ↗Addiction as a psychiatric disorder involves interaction of inherited predispositions and environmental factors. Similarly to humans, laboratory animals self-administer addictive drugs, whose appetitive properties result from activation and suppression of brain reward and aversive pathways, respectively. The ventral tegmental area (VTA) where dopamine (DA) cells are located is a key component of brain reward circu…
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