Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
99 articles
Newest firstBackground Despite limited research, cancer patients are opting for compounds found in cannabis, like tetrahydrocannabinol (THC) and cannabidiol (CBD), to improve their sleep. The purpose of this study was to examine the therapeutic value of cannabis for sleep. Methods Patient-reported symptom responses were obtained from 1962 cancer patients enrolled in the Minnesota Medical Cannabis Program (MMCP) from 2015 to 2…
Open article record in new tab ↗Purpose This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis. Methods This study employed a convergent, parallel mixed methods design utilizing focus group and questionnaire data to assess the presence of stigma among a sample of CS (n = 23) who use (n = 10) and do not use (n = 13) cannabis to manage symptoms. CS were…
Open article record in new tab ↗Purpose Cancer survivors in a state with no legal access to cannabis may be hesitant to discuss their cannabis use with providers, particularly in light of legal consequences which disproportionately affect certain racial groups. This study examined potential racial disparities in the relationship of cannabis use status with patient-provider discussions of and attitudes toward cannabis in a state where there is no…
Open article record in new tab ↗Background Opioid use and adverse events among cancer patients may change with access to medical marijuana. This study investigated the impacts of medical marijuana legalization (MML) since 2016. Methods Using a difference-in-differences approach and 2016 to 2022 private insurance claims data, this cross-sectional study included patients (aged 18-64 years) undergoing resection surgery for newly diagnosed (female)…
Open article record in new tab ↗Objective To examine the association between adverse childhood events (ACEs) and cannabis use among adult cancer survivors in the United States. Methods We conducted a cross-sectional study of cancer survivors ≥ 18 years old using 2020 Behavioral Risk Factor Surveillance System data. ACEs were categorized as 0, 1, 2-3, and ≥ 4. Weighted multivariable logistic regression estimated the odds of cannabis use by ACE ca…
Purpose There is increasing interest in the use of cannabis products to alleviate symptom burden among cancer patients. Although data remain limited, some evidence suggests that state legalization of cannabis is associated with reduced opioid use. Indices of area-level social determinants of health may provide insights into the patterns of symptom-managing behaviors in the context of health equity. Methods Residen…
Open article record in new tab ↗As legalization of cannabis increases worldwide, vaping cannabis is gaining popularity due to the belief that it is less harmful than smoking cannabis. However, the safety of cannabis vaping remains untested. To address this, we developed a physiologically relevant method for in vitro assessment of cannabis vapor on alveolar epithelial cell cultures. We compared the transcriptional response in three in vitro model…
Open article record in new tab ↗Introduction Tobacco and other substance co-use has not been examined in adolescent and young adult (AYA) cancer survivors. We compared the prevalence of past-month co-use of tobacco+cannabis, alcohol and illicit drugs between AYAs with and without a cancer history and considered associations between co-use and nicotine dependence in AYA cancer survivors who use tobacco, exploring if past-year major depression mod…
Tetrahydrocurcumin (THC), a curcumin derivative, shows potential in oncology and neurology. It regulates NF-κB, reduces inflammation, promotes cancer cell apoptosis, inhibits tumor angiogenesis, and enhances antioxidants, aiding in treating inflammation-related cancers. In neurology, THC's anti-inflammatory and antioxidant properties protect neurons, reduce neuroinflammation, and support autophagy for cellular deb…
Open article record in new tab ↗Cannabis use among cancer patients for managing treatment-related symptoms is increasing, yet little is known about patterns in patient-provider communication. This study examines demographic differences in cannabis use communication at a National Cancer Institute-designated cancer center. The analysis included cancer patients aged ≥ 18 years who self-reported current cannabis use (past 30 days) and had visited Sy…
Purpose of the review As cancer survival rates are increasing, alternative treatments to improve quality of life, such as cannabinoids, are gaining attention. Although cannabinoids are widely used to manage cancer-related symptoms, clear guidelines are lacking. This systematic review and meta-analysis assessed the safety and efficacy of cannabinoids in the management of symptoms among cancer patients. The study pr…
Open article record in new tab ↗Despite medicinal cannabis gaining popularity for managing symptoms in cancer patients, a knowledge gap exists in patient-provider communication crucial for monitoring outcomes, optimizing dosing, and educating healthcare providers to integrate cannabis into treatment plans. Our goal is to understand communication dynamics, identify gaps, and pave the way for effective cannabis communication for individuals living…
Background Cannabinoids have potential efficacy as prophylaxis for chemotherapy-induced nausea and vomiting (CINV), but no recent meta-analysis has reported on their relative efficacy compared to other antiemetics. The aim of this meta-analysis is to examine the relative efficacy of cannabinoids for prophylaxis of CINV. Methods A literature search was conducted in OVID Medline, EMBASE, and Cochrane Central Registe…
Open article record in new tab ↗Introduction Cancer patients are increasingly turning to cannabis products to modulate physical and psychological symptoms despite limited evidence supporting their efficacy. We aimed to explore cancer patients' self-reported anxiety and depression symptoms in response to cannabis use. Methods This longitudinal study examined how patient-reported anxiety and depression symptoms varied according to the dose, ratio…
Open article record in new tab ↗Cannabidiol (CBD), a phytocannabinoid derived from Cannabis sativa, has demonstrated therapeutic potential across various diseases, including cancer. This study evaluates the cytotoxic effects of CBD on three human cancer cell lines (HeLa, MDA-MB-231, and CaCo-2) and two non-cancerous cell lines (HaCaT and HUVEC) used as a control. Cells were treated with CBD at concentrations of 5, 10, and 20 µM for 24, 48, 72, a…
Background Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI. Objectives Using a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles. Methods Patients completed the Attentional Function Index six times ov…
Cannabinoids relieve pain, nausea, anorexia and anxiety, and improve quality of life in several cancer patients. The immunotherapy with checkpoint inhibitors (ICIs), although very successful in a subset of patients, is accompanied by moderate to severe immune-related adverse events (ir-AE) that often necessitate its discontinuation. Because of their role in symptomatic relief, cannabinoids have been used in combin…
Monoacylglycerol lipase (MAGL) is a key serine hydrolase involved in lipid metabolism, catalyzing the hydrolysis of monoacylglycerols into free fatty acids and glycerol. MAGL plays a central role in regulating endocannabinoid signaling and lipid homeostasis, processes often dysregulated in cancer and other pathological conditions. In recent years, MAGL has emerged as a promising therapeutic target, particularly in…
Purpose Patients with cancer commonly access cannabis hoping to relieve their symptoms. This study assessed whether a 1:1 10 mg/ml THC:CBD combination oil could improve total symptom burden in patients with advanced cancer over that provided by palliative care alone. Methods Participants were randomised to medicinal cannabis (MC) or placebo oil; dose escalated over 14 days according to tolerance and efficacy and c…
Introduction Cannabidiol (CBD) is widely used as a natural alternative supplementary treatment for side effects and symptom relief in many diseases. Although the benefits and risks of using CBDs are still largely unknown, consumption has grown constantly. Methods Primary human neutrophils were isolated and exposed to CBD. Neutrophil functions such as oxidative burst, cytokine and chemokine production, bacterial ki…