Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
46 articles
Newest firstAbstract Background Migraine is a debilitating neurological disorder affecting ~ 15% of the global population with greater prevalence in females. Cannabinoid 1 and 2 receptor (CB1R and CB2R) agonists alleviate migraine symptoms. However, central nervous system (CNS) side effects mediated by CB1Rs limit their widespread use. We developed peripherally restricted cannabinoids (PRCBs) which lack CNS side effects. Here…
Open article record in new tab ↗Abstract The use of Δ8-tetrahydrocannabinol (Δ8-THC) has become increasingly prevalent in the United States but its metabolic pathways remain poorly characterized. This study aimed to identify the key enzymes responsible for the 11′-hydroxylation of Δ8-THC, its primary metabolic pathway, and assess the effect of metabolizing enzyme genotype on this activity. The intrinsic clearance of recombinant (r) CYP2C9 was >…
Open article record in new tab ↗Abstract Rationale: Fast-acting edible cannabis products are marketed as producing quicker effects than standard edibles, but whether faster absorption translates into earlier cognitive impairment due to cannabis intoxication is unclear. Objectives : We compared fast-acting, standard, and placebo edibles in a double-blind, within-subject crossover study of 20 adult individuals who frequently use cannabis. Methods:…
Abstract Background: Adverse Childhood experiences (ACEs) disproportionately affect minoritized and low-income youth. Those with four or more ACEs are particularly vulnerable to chronic, unpredictable stress, which shapes their stress perception and response. Higher exposure to ACEs is associated with an increased risk of self-dysregulation, early initiation of alcohol and substance use, and cardiometabolic issues…
Abstract Introduction States across the US continue to legalize recreational cannabis to shift consumers from illicit to regulated markets. Yet evidence on whether legalization increases the share of cannabis obtained legally remains limited. This study examines how legalization influences cannabis sourcing behavior using nationally representative panel data and recent policy variation. Methods We use three waves…
Open article record in new tab ↗Abstract Introduction: Studies have shown that tetrahydrocannabinol (THC) consumption can acutely increase heart rate (HR) regardless of the percent concentration of the product consumed, mode of consumption (e.g. flower, edibles, concentrate), and tolerance. Prior studies have found that the magnitude of this effect is slightly larger in inhaled products, however few purposeful studies on HR response to commercia…
Open article record in new tab ↗Abstract Emerging evidence from both human and preclinical research indicates that cannabis use during pregnancy can influence offspring neurodevelopmental outcomes. Δ 9 -Tetrahydrocannabinol (THC), the psychoactive compound in cannabis, permeates the placental barrier and modulates the endocannabinoid system, a critical regulator of neurodevelopmental processes. Although converging findings suggest that prenatal…
Open article record in new tab ↗Abstract Rationale : Methylphenidate is commonly prescribed to manage symptoms of attention-deficit/hyperactivity disorder (ADHD), but like other stimulants it has limited effectiveness. Methylphenidate works by increasing the synaptic availability of dopamine and norepinephrine, resulting in stimulation of dopaminergic and adrenergic receptors. One hypothesis is that selective receptor targeting may be more effec…
Open article record in new tab ↗Abstract Cannabis remains the most widely used illicit substance in the United States, specifically among young adults. Previous research identifies emotion dysregulation as a predictor of cannabis use, yet there remains some uncertainty in the literature regarding which facets of emotion dysregulation are the most important in relation to cannabis use. Indeed, the studies that have compared the facet-level associ…
Open article record in new tab ↗Abstract Background Neuroinflammation and blood–brain barrier (BBB) dysfunction are key contributors to the pathogenesis of many neurological disorders. Cannabinoid receptor 2 (CB 2 ) agonists possess anti-inflammatory properties and may represent promising therapeutic agents for preserving BBB integrity. This study evaluated the effects of novel orally bioavailable CB 2 receptor agonists on leukocyte–endothelial…
Open article record in new tab ↗Abstract Progressive supranuclear palsy (PSP) is a neurodegenerative disease diagnosed according to its histopathologic pattern of tau proteinopathy (“tauopathy”). It is increasingly appreciated that PSP is heterogeneous in both clinical and pathological presentations. However, the prevalence of PSP subtypes, in comparison to other tauopathies, remain incompletely characterized. Here we analyzed NACC Neuropatholog…
Abstract Background: Substance use can negatively impact treatment adherence and health outcomes, thus exacerbating the burden of the disease. This study determined the prevalence and factors associated with substance use among patients with TB disease in Kampala, Uganda. Methods: This was a cross-sectional study of 144 patients with drug-susceptible TB enrolled from July 2020 to March 2021 across five health faci…
Open article record in new tab ↗Abstract The infection with the Human Immunodeficiency Virus is associated with several comorbidities despite suppressive antiretrovirals, which include consequences to the Central Nervous System (CNS), where disruption of the blood-brain barrier (BBB) a major underlying factor in the resulting chronic inflammation and pathogenesis. Currently, the use of cannabis and cannabinoid derivatives among persons living wi…
Open article record in new tab ↗Abstract Purpose. This study aims to assess perceived stigma among CS who use or consider use of cannabis. Methods. This study employed a convergent, parallel mixed methods design utilizing focus group and questionnaire data to assess the presence of stigma among a sample of CS (n = 23) who use (n = 10) and do not use (n = 13) cannabis to manage symptoms. CS were recruited from a multi-site observational study in…
Open article record in new tab ↗Abstract Both hot and cold sensation of the homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels have been predicted by a single Gibbs-Helmholtz equation for a change in molar heat capacity. However, cold activation has not been confirmed for those heat-responsive TRPV1-4 channels. Given the cooperative heat unfolding and non-cooperative cold unfolding behaviors in proteins,…
Open article record in new tab ↗Abstract The rising legal acceptance of cannabis and the high comorbidity between cannabis use disorder (CUD) and post-traumatic stress disorder (PTSD) highlight the importance of understanding how stress and cannabis influence the brain. We recently discovered that cannabis use promotes two PTSD-like symptoms: avoidance coping behaviors and the generalization of stress-coping responses to a neutral stimulus not p…
Open article record in new tab ↗Abstract Background People living with HIV experience high rates of mental health disorders, but the comorbidity patterns of these conditions remain poorly understood. Identifying how disorders cluster and which diagnoses are most central may guide more effective screening and integrated treatment strategies. Methods This cross-sectional study used electronic health records and survey data from the National Instit…
Open article record in new tab ↗Abstract The endocannabinoid (eCB) system has been proposed as a potential target for developing new medications for opioid use disorder (OUD). However, the status of the eCB system, specifically brain cannabinoid receptor type 1 (CB1R) in OUD, is unknown. In this study, CB1R availability was measured in males with OUD on stable opioid agonist treatment (OAT) (n = 10) versus healthy controls (HC) (n = 18), using H…
Abstract Recent studies suggest that behavioral and temperament characteristics provide insight into individual differences in drug use behaviors, but few studies have described their prospective associations. We investigated how temperament and behavioral characteristics associate with drinking and cannabis use prior to and during the start of college. Participants were 252 college students (175 females, mean age…
Open article record in new tab ↗Abstract The “Pain Overlap Theory”1 proposes that the experience of social pain overlaps with and amplifies the experience of physical pain by sharing parts of the same underlying processing systems 2–6. In humans, the insular cortex has been implicated in this overlap of physical and social pain, but a mechanistic link has not been made2,4,5,7–9. To determine whether social pain can subsequently impact responses…
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