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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
126 articles
Newest firstBackground Chronic exposure to addictive substances induces persistent alterations in neural dynamics, reflecting maladaptive brain plasticity. While such changes are well documented using neuroimaging techniques, their electrophysiological signatures-particularly those derived from nonlinear EEG complexity-remain insufficiently explored across diverse substance use profiles. This preliminary study aims to investi…
Open article record in new tab ↗Substance use disorders (SUDs) remain a major public health concern and contribute substantially to compromised quality of life, mortality, and healthcare burden. In the United States alone, millions of individuals are affected by alcohol use disorder (AUD), tobacco use disorder (TUD), and opioid use disorder (OUD), with many cases complicated by co-existing anxiety and stress-related disorders. Piper methysticum…
Open article record in new tab ↗Substance use disorder (SUD) is a major worldwide health problem with a historic global high of 316 million people using drugs, representing a 15% rise in prevalence over the previous decade. A comprehensive understanding of the pathophysiology of SUD will enable the development of novel therapeutic strategies to improve patient outcomes. Preclinical research on the neurobiology of SUD primarily focuses on the imm…
Open article record in new tab ↗The British Association for Psychopharmacology guidelines for the management of substance dependence focus primarily on the pharmacological aspects of treatment. A group of international experts from a wide range of disciplines reviewed the current evidence in their field, considered the strength of the evidence and discussed the clinical implications at a consensus meeting. The guidelines focus on the pharmacolog…
Purpose Substance use and substance use disorders (SUD) disproportionately affect people with disabilities (PWD), yet PWD remain under-represented in addiction treatment literature. While recent work has begun to address SUD prevalence and recovery service gaps, little is known about how disability status shapes substance use outcomes. The present study is the first to our knowledge to investigate how recovery, me…
Background Conventional psychological and pharmacological substance abuse treatments are limited to moderate effect sizes and fail to magnify outcomes when combined. Analog psychedelic agents N, N-dimethyltryptamine (DMT) and 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) show therapeutic potential for treatment-resistant psychiatric disorders including substance addictions. Methods This systematic review and meta-…
IntroKratom use is growing for both therapeutic and non-therapeutic effects. This survey assessed the temporal relationship between kratom initiation and prior, subsequent, or concurrent substance use or medical treatment.MethodsThis cross-sectional, anonymous electronic survey was disseminated to American Kratom Association and Global Kratom Coalition members from 3/2025-9/2025. Adults aged ≥18 years who reported…
Open article record in new tab ↗Background Two-thirds of adults in the United States (U.S.) find recreational and medical cannabis use acceptable. Evidence shows that cannabis use is an effective treatment for pain, and as a harm reducing therapeutic for Substance Use Disorder (SUD). In contrast to most SUD treatment models, some models allow illegal substance use as a harm reduction strategy, which is the case for the SUD treatment program exam…
Background Substance use disorder (SUD) is a rapidly growing public health challenge in developing countries across socioeconomic divides. In sub-Saharan Africa, the situation of SUD is particularly concerning and largely unexplored, with projections indicating a worsening trend. Aims This study seeks to fill the gap by generating insights into the multifaceted nature of alcohol and drug use disorders among a youn…
Open article record in new tab ↗Purpose of the review Brain stimulation techniques targeting neuronal pathways are evolving as a novel therapeutic option for substance use disorders. This study aims to provide an overview of the current research landscape on brain stimulation in addiction psychiatry by analyzing data from ClinicalTrials.gov. It intends to describe the global trends in these trials, highlight the findings reported in their public…
Background Exposure to childhood maltreatment (CM) has serious consequences on the health of affected individuals, potentially elevating vulnerability to various psychopathologies, including substance use disorders (SUDs). Recent investigations have implicated several biological signaling systems in vulnerability to SUD development following CM, including the kynurenine (KYN) pathway and endocannabinoid (eCB) syst…
OBJECTIVES: (1) To compare sociodemographic characteristics, psychopathology, and substance use patterns among women diagnosed with substance use disorder (SUD) who experienced physical abuse (PA), sexual abuse (SA), or both (PSA); (2) to describe ages of onset; (3) to evaluate the impact of PA, SA, and their interaction on clinical outcomes. METHODS: Observational retrospective study with patients from PROMUD (Dr…
BackgroundPregnant patients experiencing incarceration with a history of substance use face complex challenges accessing reproductive health services. Despite research indicating interest in these services, contraception counseling and services are often excluded from routine carceral health services.ObjectivesWe sought to examine the postpartum contraceptive plans and fulfillment of pregnant patients in the North…
Purpose of review Addiction has traditionally been framed as a disorder of negative affect and impaired downregulation of distress, yet disturbances in positive emotional experience and regulation are equally fundamental to the development and persistence of substance use disorders (SUDs). This review synthesizes clinical and psychophysiological evidence documenting the impact of addictive substances on positive e…
Open article record in new tab ↗Background In South Africa, the use of substances is associated with serious health challenges, exacerbated by limited health resources. Substance use is often associated with first-episode psychosis (FEP). Prevention and treatment protocols can be established by understanding the socio-demographic and clinical characteristics of patients with FEP. Aim To determine the prevalence, patterns, socio-demographic and c…
Background Substance use has consistently been linked with cognitive impairments. However, most previous studies have focused on highly selective samples of individuals with chronic substance use disorders and have typically relied solely on self-reports. The associations between recreational use patterns of single or multiple substances and cognitive functioning in representative samples remain unclear. Methods W…
Background Methamphetamine use, which is disproportionately prevalent among people with HIV, increases risk for cardio- and neurovascular pathology through persistent immune activation and inflammation. Preclinical studies indicate that cannabinoids may reduce markers of pro-inflammatory processes, but data from people with chronic inflammatory conditions are limited. We examined potentially interacting associatio…
Addiction is increasingly recognized as a disorder involving not only reward dysregulation but also alterations in core cognitive processes, including learning and memory. Although various studies have documented memory impairments in substance use and behavioral addictions, evidence remains inconsistent-particularly regarding verbal memory deficits and the diagnostic relevance of specific recall error types. This…
AbstractIntroductionRates of congenital syphilis and substance use disorder (SUD) have concurrently risen in pregnant patients. Specific substances and their association with inadequately treated syphilis have not yet been identified. The objective of our study was to characterize SUD, including specific drugs of use, among pregnant people with syphilis to determine the association between SUD and adequacy of syph…
Open article record in new tab ↗Objective To examine the association between adverse childhood events (ACEs) and cannabis use among adult cancer survivors in the United States. Methods We conducted a cross-sectional study of cancer survivors ≥ 18 years old using 2020 Behavioral Risk Factor Surveillance System data. ACEs were categorized as 0, 1, 2-3, and ≥ 4. Weighted multivariable logistic regression estimated the odds of cannabis use by ACE ca…