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Research Article 2026CC BYFree full text

Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study.

Thanavadee Prachason, Angelo Arias-Magnasco, Bochao Danae Lin, Jim van Os, Bart P F Rutten, Lotta-Katrin Pries +1 more

Purpose To investigate sex-dependent effects of polygenic risk (PRS-SCZ) and exposome score (ES-SCZ) for schizophrenia, both independently and jointly, on distressing psychotic experiences (PEs) in early adolescents. Method Baseline to 3-year follow-up data of the Adolescent Brain and Cognitive Development Study (ABCD) were used. PRS-SCZ and ES-SCZ were calculated to assess cumulative genetic and environmental (ch…

Archives of Women's Mental Health Europe PMC

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Research Article 2025CC BY-NCFree full text · non-commercial reuse

The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population.

Melike Karacam Dogan, Thanavadee Prachason, Bochao Lin, Lotta-Katrin Pries, Angelo Arias-Magnasco, Riccardo Bortoletto +16 more

Background Psychosis-related environmental risks in autism, along with genetic overlaps between autism and psychosis, have been well-established. However, their moderating roles in the relationship between autistic traits (ATs) and psychotic experiences (PEs) remain underexplored. Methods First-wave data from 792 twins and siblings (mean age: 17.47 ± 3.6, 60.23% female) in the TwinssCan Project were analyzed. PEs…

Schizophrenia Bulletin Open