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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
20 articles
Newest firstObjectives Poor adherence to psychopharmacological treatment may contribute to relapses in bipolar disorder (BD). We performed a systematic review and meta-analysis to identify factors associated with poor adherence in BD. Methods The protocol was registered in Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/2KZFJ). We searched main electronic databases through March 2025. Random-effects meta-an…
Open article record in new tab ↗Background Continued cannabis use in young people with first episode psychosis (FEP) has been linked to poorer clinical and functional outcomes (e.g., symptom severity, higher relapse rates). Digital harm reduction interventions may represent a promising person-centered approach to decrease at-risk cannabis use behaviors in this population. However, evidence remains limited regarding which subgroups are more likel…
Programming to prevent behavioral problems can effectively build youth skills and enhance bonding to parents and prosocial peers to delay substance use for adolescents, an important challenge for adolescents given the links between early adolescent experimentation and the chance of developing problems related to substance use as an adult. For youth at higher risk, the effective delivery of such programs could be p…
Introduction Adhering to treatment plans can be challenging for medical cannabis patients. According to the constrained-disorder principle (CDP), biological systems are defined by their degree of variability. CDP-based second-generation artificial intelligence (AI) systems use personalized variability signatures to improve chronic medication response. Aim We retrospectively analyzed real-world data regarding chron…
Open article record in new tab ↗BackgroundCervical cancer screening is a critical public health intervention that facilitate the early detection and treatment of precancerous cervical lesions before they progress to invasive cancer. The effectiveness of this intervention largely depends on timely and consistent adherence to recommended follow-up screenings. However, in Tanzania, the adherence to these crucial screenings and its associated predic…
Open article record in new tab ↗Treatment default in tuberculosis care undermines disease control efforts, contributing to ongoing transmission, drug resistance, and adverse health outcomes. Zambia, like many high-burden countries, continues to face challenges with patient adherence to tuberculosis (TB) treatment, especially in urban informal settlements. Despite the national TB programs efforts, limited research has specifically explored the ca…
Open article record in new tab ↗Back GroundThe prevalence of hypertension among adults in Ethiopia is about 20.6%, and antihypertensive medication adherence is one of the indicators of treatment success for hypertensive patients. However, little is known about the current prevalence and the factors associated with antihypertensive medication adherence in the study area. Patients and MethodsAn institution-based cross-sectional study was conducted…
Open article record in new tab ↗Introduction Medical cannabis treatment for autistic children has recently become popular, and studies have focused on examining the treatment's effects on children's symptom presentation, reported side effects, and dropout rates. However, no previous study has investigated the factors influencing adherence and dropout rates in cannabis treatment. Method This explanatory sequential mixed-methods study explored the…
Open article record in new tab ↗Background Self-reported adherence to direct-acting antivirals (DAAs) to treat hepatitis C virus (HCV) among persons who inject drugs (PWID) is often an overreport of objectively measured adherence. The association of such overreporting with sustained virologic response (SVR) is understudied. This study among PWID aimed to determine a threshold of overreporting adherence that optimally predicts lower SVR rates, an…
Background Long-acting (LA) injectable preexposure prophylaxis (PrEP) and on-demand PrEP may improve overall PrEP uptake among men who have sex with men (MSM), but little is understood about the PrEP option preferences of MSM in practical scenarios where they may choose between various PrEP options. Objective This study aims to examine the preferences for starting various PrEP options among a US nationwide online…
Understanding the influence of cultural practices on maternal health is crucial in addressing the nutritional challenges faced by pregnant women in rural Bangladesh. Despite significant improvements in maternal and child health indicators, food taboos remain prevalent, impacting the nutritional well-being and health outcomes of vulnerable populations. This study explored food taboos and factors related to their ad…
Open article record in new tab ↗BackgroundEffective dengue management enhances the chances of survival. The level of adherence to the suggestions in northern Peru is uncertain. The primary aim of the study was to assess adherence to the 2016 PAHO guideline on dengue in a hospital located in northern Peru during the period from 2022 to 2023. Methodology/principal findingsThe study performed a cross-sectional design and exploratory analysis, revie…
Open article record in new tab ↗Tobacco use poses major health risks and is a major contributor to causes of death worldwide. Mobile phone-based cessation apps for this substance are gaining popularity, often used as a component of traditional interventions. This study aimed to analyze adherence to an intervention using a mobile phone application (App-therapy Prescinde (v1)) as a function of sociodemographic variables (age, gender, educational l…
Open article record in new tab ↗Highlights•People living with HIV (PWH) with substance use or alcohol use often have detectable plasma HIV viral loads that are predictive of negative clinical outcomes.•Among PWH with substance or alcohol use, it is not known what proportion of the observed detectable HIV viremia is mediated through medication nonadherence.•Use of amphetamines, opioids, and multiple substances but not alcohol predicted having a d…
Open article record in new tab ↗BackgroundThe use of anti-retroviral therapy (ART) in management and prevention of HIV/AIDS epidemic is a globally accepted strategy. In Uganda, despite the efforts to increase uptake of ART, adherence remains a huge challenge. This study, therefore, was conducted to explore psychosocial factors which influenced non-adherence to ART among young adults in Eastern Uganda. MethodsThis was an exploratory qualitative s…
Open article record in new tab ↗People with HIV (PWH) report substance use at higher rates than HIV-uninfected individuals. The potential negative impact of single and polysubstance use on HIV treatment among diverse samples of PWH is underexplored. PWH were recruited from the Center for Positive Living at the Montefiore Medical Center (Bronx, NY, USA) from May 2017-April 2018 and completed a cross-sectional survey with measures of substance use…
Open article record in new tab ↗Background Cannabis is the most-frequently used illicit drug in Europe. Over the last few years in Spain, treatment demand has increased, yet most cannabis users do not seek treatment despite the related problems. A web-based self-help tool, like CANreduce 2.0, could help these users to control their consumption. Methods This study protocol describes a three-arm randomized controlled trial (RCT) comparing the effe…
Background Despite the absence of rigorous prospective studies, there has been an increase in the use of cannabis-based medicinal products. During the study period, the use of medical cannabis in Israel was tightly regulated by national policy. Through a prospective study of approximately 10,000 patients, we aimed to characterize the medical cannabis patient population as well as to identify treatment adherence, s…
Open article record in new tab ↗IntroductionHIV pre-exposure prophylaxis (PrEP) is a key component of HIV combination prevention. Effective prevention needs people to adhere to PrEP during periods of risk and remain in care. However, relevant models of care are under-researched. Using data from the first two years of Scotlands PrEP programme, we explored barriers and facilitators to PrEP adherence and retention in care and systematically develop…
Objective: Antipsychotic medication non-adherence has detrimental effects on patients' clinical outcome. It is unclear which risk factors affect adherence most and which interventions are effective at improving adherence to antipsychotic medication. The aim of this systematic review is to summarize evidence exploring risk factors of non-adherence to antipsychotic treatment and effectiveness of intervention to impr…
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