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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
103 articles
Newest firstThe endocannabinoid system (ECS) is increasingly recognized as a central regulator of immune homeostasis, integrating neural, metabolic, and immune signaling to maintain physiological equilibrium. This Perspective examines the “therapeutic paradox” of endocannabinoid immunomodulation, whereby anti-inflammatory and tissue-protective effects are mechanistically linked to transient immunosuppression. Although cannabi…
Open article record in new tab ↗Despite public health concerns, fentanyl, cocaine, and other illicit drug contaminants remain largely understudied in unregulated cannabis. Here, we developed an analytical method to quantify a panel of common illicit drugs in cannabis and tested the law enforcement seizures in Arizona and California in evaluation of the illicit drug contamination in black- and gray-market cannabis. One hundred and eighteen cannab…
Open article record in new tab ↗Medical cannabis use is steadily increasing worldwide, including among pregnant and breastfeeding women. This Perspective provides an overview of current evidence regarding cannabis exposure during pregnancy and lactation and its implications for clinical decision-making. The available literature indicates relatively consistent evidence linking prenatal Δ9-tetrahydrocannabinol (THC) exposure with adverse perinatal…
Open article record in new tab ↗The Kunming-Montreal Global Biodiversity Framework (KMGBF), adopted in 2022, set forth ambitious targets to halt and reverse biodiversity loss by 2030. However, translating these commitments into actionable strategies has proven challenging due to several factors. These include insufficient financing of biodiversity initiatives, lack of capacity and institutional coordination at the national and subnational level,…
Open article record in new tab ↗Biochar application to soil has been promoted to mitigate climate change by reducing greenhouse gas (GHG) emissions, yet significant uncertainty exists in quantifying soil nitrous oxide (N2O) emissions from biochar-amended soils. We evaluated soil N2O emissions from soils amended with biochar prepared from diverse agricultural and forest biomass and underlying biogeochemical mechanisms using long-term soil incubat…
Introduction As medical cannabis becomes more accessible, product quality must be evaluated. Researchers identified a social media community where Florida medical cannabis patients discuss personal experiences. The objective of this study was to analyze posts in this community to understand patient experience with products purchased from Florida medical dispensaries they believed to be contamination, perceptions o…
Open article record in new tab ↗Food supplements are one of the most widely marketed food categories in the world. In relation to several cases of adverse effects reported due to the plant substances contained in these products, the attention of the scientific communities and public decision-makers should be directed to the physiological effects that can be attributed to these substances and that encourage their increasing sales to consumers. Th…
Open article record in new tab ↗Introduction HHV-6 infection is usually asymptomatic or self-limited, although in certain populations, particularly in immunocompromised patients, it can cause serious infections. Hepatic involvement, previously described in immunocompromised and occasionally in immunocompetent adults, can lead to acute liver failure (ALF). Case presentation We report a case of a 20-year-old female with no known liver disease, who…
Open article record in new tab ↗Substance-induced psychosis is a recognized clinical entity, commonly linked to cannabinoids, stimulants, hallucinogens, alcohol, and polysubstance use. These agents may provoke transient or persistent psychotic symptoms during intoxication or withdrawal. Opioids, however, constitute a noteworthy exception: psychosis is rarely observed during opioid intoxication, and emerging data suggest that opioid agonists migh…
Open article record in new tab ↗Cardiovascular diseases are a leading cause of death worldwide, and the process of cardiac remodeling lies at the core of most of these diseases. Sustained cardiac remodeling almost unavoidably ends in progressive muscle dysfunction, heart failure, and ultimately death. Therefore, in order to attenuate cardiac remodeling and reduce mortality, different therapies have been used, but it is important to identify adju…
Open article record in new tab ↗Introduction As legalization of medical cannabis (MC) in the USA expands, there remains uncertainty in clinical guidance. Healthcare professionals remain unprepared to communicate to patients the therapeutic outcomes and possible adverse effects of MC utilization. There is limited training provided at all levels of medical education, even for professionals with many years of clinical practice. Additionally, there…
Open article record in new tab ↗Compulsive buying (CB) presents itself with uncontrollable or excessive urges and preoccupations with behaviors related to spending money that have detrimental consequences. Compulsive buying disorder (CBD) can result in remorse and regret over purchases, guilt, shame, issues with finances, and interpersonal difficulties. Despite the growing understanding of the phenomenology of CBD, only some evidence-based thera…
Open article record in new tab ↗Public health discussions now apply the label of 'unhealthy commodities' to items attractive to consumers but which bring harm to health and welfare. The list includes tobacco, alcohol, cannabis and other drugs, sugar-sweetened beverages, overprocessed foods and commercial gambling. The histories of markets and controls in such commodities vary, with commerce in alcohol, drugs and gambling prohibited in many place…
Open article record in new tab ↗Palmitoylethanolamide (PEA) is an endogenous lipid mediator belonging to the N-acyl-ethanolamine family, widely recognized for its multifaceted effects on neuroprotection, chronic pain management, and immune modulation. As a naturally occurring compound, PEA plays a crucial role in maintaining homeostasis under conditions of cellular stress and inflammation. Its pharmacological effects are primarily mediated throu…
Open article record in new tab ↗Alzheimer's disease (AD) is a complex neurodegenerative disorder where age, genetic factors and sleep disturbance significantly influence disease risk. Recent genome-wide association studies identified a C/T missense variant (rs141749679) in the sortilin (SORT1) gene linked to heightened AD risk, revealing SORT1's role as a key player in the disease's pathophysiology. This type I membrane glycoprotein is implicate…
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