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Research Article 2023CC BYFree full text

Glucoregulatory disruption in male mice offspring induced by maternal transfer of endocrine disrupting brominated flame retardants in DE-71.

Elena V. Kozlova, Bhuvaneswari D. Chinthirla, Anthony E. Bishay, Pedro A. Pérez, Maximillian E. Denys, Julia M. Krum +2 more

Introduction Polybrominated diphenyl ethers (PBDEs) are commercially used flame retardants that bioaccumulate in human tissues, including breast milk. PBDEs produce endocrine and metabolic disruption in experimental animals and have been associated with diabetes and metabolic syndrome (MetS) in humans, however, their sex-specific diabetogenic effects are not completely understood. Our past works show glucolipid dy…

Frontiers in Endocrinology Europe PMC

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Research Article 2020CC BYFree full text

Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring.

Elena V. Kozlova, Bhuvaneswari D. Chinthirla, Pedro A. Pérez, Nicholas V. DiPatrizio, Donovan A. Argueta, Allison L. Phillips +7 more

Polybrominated diphenyl ethers (PBDEs) are brominated flame retardant chemicals and environmental contaminants with endocrine-disrupting properties that are associated with diabetes and metabolic syndrome in humans. However, their diabetogenic actions are not completely characterized or understood. In this study, we investigated the effects of DE-71, a commercial penta-mixture of PBDEs, on glucoregulatory paramete…

Scientific Reports