Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
21 articles
Newest firstBackgroundTuberculosis (TB) remains a critical public health challenge, with two-thirds of the global TB burden in ten Asian countries. Social vulnerabilities, comorbidities, health inequity, multi-dimensional poverty, malnutrition, and barriers to healthcare access continue to fuel TB epidemic. Inability to detect asymptomatic and sub-clinical TB, combined with passive approach in service delivery and overrelianc…
Open article record in new tab ↗BackgroundRespiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections and hospitalizations among infants in Canada. New long-acting monoclonal antibodies (mAbs) and vaccines administered during pregnancy have expanded prevention options, yet the most cost-effective immunization program remains uncertain. MethodsWe updated a Canadian cost-utility model to evaluate seven seasonal RSV p…
ObjectiveThis study is to evaluate the cost-effectiveness of an annual screening program for diabetic retinopathy (DR) at primary healthcare level among patients with type 2 diabetes mellitus (type 2 DM) from a societal perspective in Danang city, Vietnam. MethodsA Markov model was developed to compare costs and effects of an annual screening program for DR using non-mydriatic fundus photography with the absence o…
Open article record in new tab ↗Background Over the past 20 years, one-stage laparoscopic common bile duct exploration (LCBDE) combined with laparoscopic cholecystectomy (LC) has gained wide acceptance for the management of cholecystocholedocholithiasis (CCL). Despite this, the two-stage endo-laparoscopic approach, consisting of endoscopic retrograde cholangiopancreatography (ERCP) followed by LC, remains the most commonly used strategy. This st…
BackgroundCraniotomy is one of the most resource-intensive neurosurgical procedures, yet comparative information on its cost-effectiveness across different pathologies is limited. Differences in surgical techniques such as decompressive versus standard craniotomy, awake versus asleep resections, and endoscopic versus open approaches have major implications for outcomes and healthcare expenditure. This systematic r…
1.The prescribing of multiple medicines to one individual, or polypharmacy, is increasingly common. While the use of multiple medications by a patient is often appropriate, in some cases prescribed medicines may not have the intended benefit and may even cause harm, and it is important to understand the clinical and economic implications of polypharmacy and interventions to optimise prescribing. In the UK, most on…
Open article record in new tab ↗BackgroundA threshold of [≥] 500 ml blood loss within 24 hours of childbirth has conventionally been used to initiate postpartum haemorrhage (PPH) treatment. We assessed the cost-effectiveness of initiating PPH treatment at lower blood loss thresholds, alone and in combination with any other abnormal haemodynamic marker (pulse, systolic and diastolic blood pressure, shock index), compared with the conventional [≥]…
Open article record in new tab ↗BackgroundHigh-quality evidence suggests that specialist palliative care reduces the odds of dying in hospital. The associated economic implications have not been established. AimTo evaluate the cost-effectiveness of home- and hospital-based specialist palliative care for adults in England. DesignHealth-economic decision-modelling using five-state Markov cohort models with a 24-hour cycle and lifetime horizon. Set…
Open article record in new tab ↗BackgroundPeople with intellectual disabilities (ID) suffer higher rates of major osteoporotic fracture (MOF), including hip fracture (HF), at younger ages than the general population. We compared the cost-effectiveness of alternative fracture risk assessment strategies for people with ID aged [≥]40 years from a UK National Health Services perspective over a lifetime horizon. MethodsThree strategies were assessed:…
Open article record in new tab ↗BackgroundPersistent fatigue is a frequent symptom in chronic medical conditions. Systematic reviews of non-pharmacological interventions for fatigue have identified interventions that are effective at reducing fatigue, but there is limited published evidence on the cost-effectiveness of these interventions. ObjectiveTo identify non-pharmacological fatigue interventions that have the potential to be cost-effective…
Open article record in new tab ↗Far-UVC light (wavelengths 207-230 nm) can be used directly overhead, whilst having germicidal capabilities to improve indoor air quality. This study evaluates the cost-benefit of implementing far-UVC devices in various settings in Switzerland and Germany. We used the CERN Airborne Model for Indoor Risk Assessment (CAiMIRA) to model infection risk reduction in restaurants, offices, and waiting rooms, considering f…
BackgroundLong Covid has emerged as a complex health condition for millions of people worldwide following the COVID-19 pandemic. Previously, we have categorised healthcare pathways for patients after discharge from hospital with COVID-19 across 45 UK sites. The aim of this work was to estimate the clinical and cost-effectiveness of these pathways. MethodsWe examined prospectively collected data from 1,013 patients…
Open article record in new tab ↗BackgroundTuberculosis (TB) remains a significant cause of morbidity and mortality globally, disproportionately affecting low- and middle-income countries (LMIC). Accessing Directly Observed Therapy (DOT) is associated with out-of-pocket costs and stigma. Video-observed therapy (VOT) is an alternative to DOT but evidence from LMIC with high TB burden is limited. To make recommendations for future VOT-related resea…
Open article record in new tab ↗BackgroundNivolumab in combination with chemotherapy significantly improves survival in patients with gastric/gastroesophageal junction (G/GEJ)/esophageal adenocarcinoma.The purpose of this study was to evaluate the cost-effectiveness of Nivolumab plus chemotherapy for G/GEJ/esophageal adenocarcinoma. MethodsA Markov model was developed on the basis of the US healthcare payers perspectives. We estimated the costs…
Open article record in new tab ↗BackgroundNHS England issued commissioning guidance on 18 low-priority treatments which should not be routinely prescribed in primary care. We aimed to monitor the impact of an educational intervention delivered to regional prescribing advisors by senior pharmacists from NHS England on the primary care spend on low-priority items. MethodsAn opportunistic randomised, controlled parallel-group trial. Participants (c…
Open article record in new tab ↗ObjectivesTo assess the potential clinical impact and cost-effectiveness of COVID-19 mRNA vaccines updated for Fall 2023 in adults [≥]18 years over a 1-year analytic time horizon (September 2023-August 2024). MethodsA compartmental Susceptible-Exposed-Infected-Recovered model was updated to reflect COVID-19 in summer 2023. Numbers of symptomatic infections, COVID-19 related hospitalizations and deaths, and costs a…
Open article record in new tab ↗Background Lack of effective early screening is a major obstacle for reducing the fatality rate and disease burden of dengue. In light of this, the government of Tamil Nadu has adopted a decentralized dengue screening strategy at the primary healthcare (PHC) facilities using blood platelet count. Our objective was to determine the cost-effectiveness of a decentralized screening strategy for dengue at PHC facilitie…
BackgroundThis study compares the health gains, costs, and cost-effectiveness of hundreds of Australian and New Zealand (NZ) health interventions conducted with comparable methods in an online interactive league table designed to inform policy. MethodsA literature review was conducted to identify peer-reviewed evaluations (2010 to 2018) arising from the Australia Cost-Effectiveness research and NZ Burden of Diseas…
Open article record in new tab ↗Background: A recent meta-analysis affirmed the benefit of medicinal cannabis for chronic neuropathic pain, a disabling and difficult-to-treat condition. As medicinal cannabis use is becoming increasingly prevalent among Americans, an exploration of its economic feasibility is warranted. We present this cost-effectiveness analysis of adjunctive cannabis pharmacotherapy for chronic peripheral neuropathy. Materials…
Open article record in new tab ↗Background Drug-resistant epilepsy negatively impacts the quality of life and is associated with increased morbidity and mortality and high costs to the healthcare system. Cannabis-based treatments may be effective in reducing seizures in this population, but whether they are cost-effective is unclear. In this systematic review, we will search for cost-effectiveness analyses involving the treatment of pediatric dr…