Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
38 articles
Newest firstBackgroundThe 2024-25 influenza season was the most severe in the United States (US) since 2017-18, with co-circulation of both influenza A virus subtypes (H1N1 and H3N2). Influenza vaccine effectiveness (VE) has varied by season, setting, and patient characteristics. MethodsUsing electronic healthcare encounter data from eight US states, we evaluated influenza vaccine effectiveness (VE) against influenza-associat…
Open article record in new tab ↗BackgroundZero-dose children, defined as those who have not received the first dose of a diphtheria-tetanus-pertussis-containing vaccine (DPT1), are a key indicator of inequitable access to immunization services. Nigeria remains one of the largest contributors to the global burden of zero-dose children. This study estimated the prevalence of zero-dose children aged 12-23 months and identified individual-and commun…
IntroductionPersistent infection with high-risk Human Papillomavirus (hr-HPV) in women is a leading cause of cervical cancer, and its co-infection among people living with HIV (PLHIV) increases the risk of HPV-associated cancer, including oropharyngeal and anogenital cancers. In sub-Saharan Africa, awareness of HPV is limited, screening and vaccine adoption are critically low, undermining efforts toward sexually t…
Open article record in new tab ↗BackgroundVaccine-preventable diseases pose significant health risks to older adults. Despite widespread vaccine availability, hesitancy related to uncertainty, misinformation, and access challenges continues to affect vaccination uptake, presenting an ongoing public health concern. ObjectiveThis study aimed to assess perceptions related to vaccination, develop age-appropriate educational strategies through commun…
Open article record in new tab ↗Background/ObjectivesIn England, gay, bisexual and other men-who-have-sex-with-men (GBMSM) are eligible for vaccinations at NHS sexual health services, including human papillomavirus (HPV), hepatitis A virus (HAV), and hepatitis B virus (HBV). However, current research shows limited understanding of the factors influencing vaccination uptake among GBMSM. This study aimed to examine the barriers and facilitators af…
Achieving routine immunization for all children remains a major challenge in many low- and middle-income countries. In 2021, 18.1 million children globally missed their first dose of the diphtheria-tetanus-pertussis vaccine (DTP1), highlighting gaps in immunization and healthcare services. The Global Immunization Agenda 2030 aims for 90% coverage of essential childhood and adolescent vaccines and a 50% reduction i…
Open article record in new tab ↗BackgroundNew adult tuberculosis (TB) vaccines are in clinical trials and may be licensed as soon as 2028. However, vaccine rollout requires addressing multiple contextual factors beyond clinical trial findings. This study explored stakeholders perspectives on the introduction a new TB vaccine in Indonesia. MethodsWe used a mixed-methods approach combining a stakeholder consultation in Jakarta (13/03/2025) among 2…
Open article record in new tab ↗BackgroundInfluenza vaccination reduces morbidity and mortality in older adults. This study identifies characteristics and reasons for vaccination uptake among the elderly to inform strategies to improve coverage. Methods: We conducted a cross-sectional survey in December 2024 among community-dwelling adults aged [≥]60 years across six Chinese cit-ies. Data collected included socio-demographic and health character…
Open article record in new tab ↗Dengue virus, with all four serotypes in cocirculation, has created significant epidemiological and economic burdens in Singapore. Despite integrated vector control programs, the magnitude and frequency of dengue outbreaks has increased over the last few decades, which highlights the limits of existing strategies. In this context, vaccination has emerged as a promising approach to enhance population immunity and c…
Open article record in new tab ↗BackgroundIn many Sub-Saharan African countries, structural health system challenges lead to a heavy reliance on informal caregivers to provide basic patient care in hospitals. These caregivers are frequently exposed to blood and body fluids (BBF), placing them at high risk of infections like hepatitis B, COVID-19, and cholera. This study aimed to assess the prevalence and determinants of BBF exposure and vaccinat…
ObjectiveHealthcare workers (HCWs) are at high risk of HBV exposure due to contact with blood and bodily fluids. In Kenya, HCWs are rarely fully vaccinated against HBV. During 2024, Kilifi County Referral Hospital (KCRH) on the Kenyan coast implemented HBV testing and vaccination for KCRH HCWs. MethodsA technical working group was formed at KCRH to implement and assess a new HBV HCW vaccination programme. Sensitis…
Open article record in new tab ↗BackgroundSeveral tuberculosis (TB) vaccines intended for adults and adolescents are in late-stage clinical trials, but there is limited research into how a new TB vaccine would be introduced. South Africa is at the forefront of TB vaccine research, with involvement in the clinical trials of leading candidates, in this study; we sought to understand what the interest, priorities and roll out approach of a potentia…
Open article record in new tab ↗BackgroundMpox remains a critical public health challenge in Central Africa, where endemic circulation of the virulent Clade I virus persists through zoonotic and human-to-human transmission. This systematic review and meta-analysis synthesize 40 years of evidence (1984-2024) to characterize Mpox epidemiology, vaccination gaps and clinical pattern in the Central African Republic (CAR), informing targeted control s…
BACKGROUNDThe expanding mpox outbreak in Africa and travel-associated cases in other continents have sparked efforts to expand vaccination. In this study and the accompanying report (Minhaj et al.), we assess the safety and long-term immunological response of MVA-BN vaccination. METHODSIn 2022, five years after the primary MVA-BN series, a third (booster) dose was administered to healthcare workers in the Democrat…
Open article record in new tab ↗BackgroundStandard precautions are infection control and prevention (ICP) measures designed to reduce the risk of transmission of infectious agents in healthcare settings. In Cameroon, maternal and neonatal mortality remain a concern. Unsystematic compliance with these measures increases the risk of HAIs and other medical hazards. The present investigation aimed at assessing the baseline understanding of hand hygi…
Open article record in new tab ↗Cameroons Expanded Program on Immunization (EPI) introduced the HPV vaccine into the routine immunization schedule in Cameroon in October 2020. However, HPV vaccine coverage has remained low, reaching only 20% by December 2022. In response, a gender-neutral vaccination (GNV) approach was adopted and implemented from January 2023 to increase acceptance, reduce stigma, and improve vaccine coverage. This study aimed…
Open article record in new tab ↗The COVID-19 pandemic highlighted the need for effective protection and rapid development of tests to track and quantify seroconversion through natural infection and vaccination. Recombinant proteins, consisting of the SARS-CoV-2 nucleocapsid and Spike Receptor Binding Domains (RBD) fused with nanoluciferase reporters (GloBodies) were designed and produced. The SARS-CoV-2 specific antibody within serum, from venou…
BackgroundAfter the prolonged COVID-19 pandemic, during which the seasonal influenza epidemic was suppressed, Japan experienced a record-breaking influenza A/H1N1 outbreak in the 2024/2025 season. This situation also raises a concern about the immunogenicity of the annual quadrivalent inactivated influenza vaccine (QIIV). This study evaluated post-vaccination hemagglutination inhibition (HI) antibody titers and th…
The Coronavirus Disease 2019 (COVID-19) pandemic has disproportionately impacted people who use drugs (PWUD). This study explored relationships between drug use, COVID-19 testing, vaccination, and infection. This cross-sectional study was conducted in Miami, Florida between March 2021 and October 2022 as part of the National Institutes of Health (NIH) Rapid Acceleration of Diagnostics-Underserved Populations (RADx…
BackgroundThe ongoing 2024 mpox outbreak in several African countries, driven by the novel Clade 1b strain, has resulted in imported cases being reported in Sweden and Thailand. The Asia Pacific (APAC) region, with little exposure to previous mpox waves, is particularly vulnerable to local transmission triggered by importation. While this highlights the importance of early preparedness, current knowledge of the vi…
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