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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
70 articles
Newest firstDespite public health concerns, fentanyl, cocaine, and other illicit drug contaminants remain largely understudied in unregulated cannabis. Here, we developed an analytical method to quantify a panel of common illicit drugs in cannabis and tested the law enforcement seizures in Arizona and California in evaluation of the illicit drug contamination in black- and gray-market cannabis. One hundred and eighteen cannab…
Open article record in new tab ↗PURPOSE OF REVIEW: This review evaluates structural neuroimaging research on substance-related psychosis to determine if these conditions share common neurobiological pathways with primary psychotic disorders, such as schizophrenia, or exhibit unique signatures. RECENT FINDINGS: Research indicates that methamphetamine, cannabis, and cocaine induce significant structural changes, including cortical thinning and gre…
Open article record in new tab ↗Recreational use of psychotogenic drugs has become more common in the last 30 years with consequent increase in drug-induced psychosis; 25-50% of such psychoses progress to schizophrenia within 5 years. Most cases result from abuse of methamphetamine or cannabis. The spread of methamphetamine psychosis has occurred without any liberalisation of laws; it is highly addictive and easy to make in small "kitchen" labs.…
Open article record in new tab ↗Purpose The global increase in the prevalence of substance use disorders (SUD) has resulted in higher mortality rates. While heroin use has decreased or stabilized, methamphetamine use is increasing, and the combined use of opioids and methamphetamine is becoming more common. FAAH is an enzyme that hydrolyzes endocannabinoid substances and plays a role in neurobehavioral processes. The aim of this study was to inv…
Methamphetamine (METH) induces neurotoxicity via excessive and incomplete autophagy, although the underlying mechanisms remain unclear. This study investigated cannabidiol (CBD)'s protective effect and the role of the 5-Hydroxytryptamine 1A receptor (5-HT1A)/adenylyl cyclase (AC)/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element-binding protein (CREB) pathway in primary hippocampal…
Open article record in new tab ↗Introduction The Australian Treatment Outcomes Profile (ATOP) is a brief clinical tool assessing substance use, health and well-being used in Australian alcohol and other drug treatment services. It is validated for use with clients using alcohol, opioids and cannabis, but not yet for clients who primarily use methamphetamine. Methods An embedded validation study was undertaken in treatment-seeking adults enrolled…
Background and objectives Patients using fentanyl have worse treatment outcomes; however, little is known about other drugs that complicate treatment. Methods A national survey (n = 396) was conducted using a random sample of clinicians waivered to prescribe buprenorphine in the United States. This study reports the results of a single survey item on clinicians' perceptions of other drugs, besides IMF, complicatin…
Background Methamphetamine use, which is disproportionately prevalent among people with HIV, increases risk for cardio- and neurovascular pathology through persistent immune activation and inflammation. Preclinical studies indicate that cannabinoids may reduce markers of pro-inflammatory processes, but data from people with chronic inflammatory conditions are limited. We examined potentially interacting associatio…
AbstractIntroductionRates of congenital syphilis and substance use disorder (SUD) have concurrently risen in pregnant patients. Specific substances and their association with inadequately treated syphilis have not yet been identified. The objective of our study was to characterize SUD, including specific drugs of use, among pregnant people with syphilis to determine the association between SUD and adequacy of syph…
Open article record in new tab ↗Background To investigate the association between prenatal illicit substance exposure and infant mortality, addressing the unclear links between specific and multiple substances and increased mortality. Methods This 16-year retrospective cohort study used Taiwan's National Health Insurance Research Database, the Taiwan Maternal and Child Health dataset, and the Integrated Illegal Drug Database, including 1 937 301…
Background Methamphetamine use disorder (MUD) is linked to a variety of cognitive and neuropsychiatric deficits. One of the illegal substances that is most frequently abused is cannabis. The general consensus is that both recreational cannabis and methamphetamine use result in a wide spectrum of severe cognitive impairments, although there have been questions raised regarding conclusions derived from published mat…
Open article record in new tab ↗Introduction This study aimed to compare the clinical oral health status of individuals with Methamphetamine (MA), Cannabis (THC), and Polysubstance (PS) use disorders to healthy controls, and assess the impact of substance type, usage duration, quantity, and oral health behaviors on dental health outcomes through comprehensive oral examinations. Methods This cross-sectional clinical study was conducted at İzmir D…
Open article record in new tab ↗This study focused on the simultaneous detection of amphetamine, 3,4-methylenedioxy methamphetamine, morphine, benzoylecgonine, and 11-nor-9-carboxy-tetrahydrocannabinol in whole blood and dried blood spot (DBS). It is aimed to select a solvent mixture for liquid-liquid extraction technique employing liquid chromatography-tandem mass spectrometry (LC-MS-MS). The obtained DBS results were compared with the whole bl…
Open article record in new tab ↗Behavioral sensitization is a phenomenon occurring after repeated administration of various psychotropic substances and it is characterized by gradually increasing response to the particular drug. It has been described for majority of addictive substances including amphetamines. It is considered to reinstate drug-seeking behaviour and plays important role in the processes associated with drug abuse and addiction.…
Open article record in new tab ↗Background and aims Ventricular tachycardia and ventricular fibrillation underlie many sudden cardiac deaths, but common lifestyle factors that predict their occurrence are poorly understood. This study aimed to assess the association between methamphetamine and cocaine, the most used illicit stimulants, and ventricular arrhythmias (VA) and mortality. Methods Healthcare databases were used to identify adults aged…
Background The aim of the study was to assess the prevalence, drug education, and associated individual level, family and peer level, school level and community/macro level risk/protective factors of current illicit drug use among in-school adolescents in the Philippines. Method The 2019 Philippines Global School-based Student Health Survey (GSHS), a nationally representative survey of teenagers aged 11 to 18 (mea…
Open article record in new tab ↗STRUCTURED ABSTRACTO_ST_ABSBackground and HypothesisC_ST_ABSCannabis use has been linked to psychotic-like experiences (PLEs). Amid increasing legalization, we examined the extent to which cannabis use is associated with PLEs after adjusting for other risk factors in a contemporary United States sample. Study DesignWe performed a cross-sectional analysis of self-reported cannabis use and four types of self-reporte…
ObjectiveThis study aimed to estimate transition rates from substance-induced psychosis (SIP) to schizophrenia or bipolar disorder, evaluate the risk associated with dual use of methamphetamine and cannabis, and identify predictors of chronicity among Iranian men. MethodsA 25-year retrospective cohort study (1999-2024) was conducted using clinical data from Shafa Hospital, a tertiary psychiatric referral center in…
Open article record in new tab ↗Introduction While known animal exposures to human "drugs of abuse" (DA) were previously considered relatively uncommon in veterinary medicine, the trends are changing. Marijuana and amphetamines are among the 20 toxicants most frequently consulted about with the Pet Poison Helpline. When such exposures occur, they are typically considered emergencies. Methods This retrospective study describes confirmed cases of…
Open article record in new tab ↗Blood-brain barrier (BBB) injury and dysfunction following infection with the human immunodeficiency virus (HIV) enables viral entry into the brain, infection of resident brain cells, neuronal injury and subsequent neurodegeneration leading to HIV-associated neurocognitive disorders (HAND). Although combination antiretroviral therapy has significantly reduced the incidence and prevalence of acquired immunodeficien…
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