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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
90 articles
Newest firstIntroduction Cannabidiol (CBD) has gained interest in equine medicine due to its potential therapeutic effects. Preclinical studies suggest that CBD may influence metabolic pathways relevant to metabolic syndrome, which present in both human and equine populations. The aim of this study was to evaluate the effects of oral CBD on metabolic parameters in Connemara ponies and to characterize its pharmacokinetics. Met…
Open article record in new tab ↗Cannabinoid-based therapies have shown analgesic, anti-inflammatory, and wound-healing potential across veterinary species; however, clinical data on long-term use of THC-rich formulations in horses remain scarce. This case report describes the use of combined oral and topical THC-rich and CBD-rich full-spectrum cannabis oils as part of a palliative care strategy in a rescued horse with severe chronic disease. A s…
Increasing resistance of gastrointestinal nematodes (GINs) to synthetic anthelmintics undermines the sustainability of small ruminant production, underscoring the urgent need for alternative control strategies. This study evaluated the in vitro larvicidal activity of aqueous extracts from 24 plant species, including forages, common weeds, and herb species with reported antiparasitic properties. Third-stage larvae…
Open article record in new tab ↗Introduction Preparations of Cannabis sativa have been used for medicinal purposes for many centuries Currently, it is known that the phytocannabinoids present in the Cannabis sativa plant can modulate the endocannabinoid system, producing a variety of effects. Among the most abundant phytocannabinoids are delta-9-tetrahydrocannabinol (19-THC) and cannabidiol (CBD). CBD lacks psychotropic properties and has been s…
Open article record in new tab ↗Chronic bronchial diseases (CBD) associated with bronchiectasis (BE) and/or bronchomalacia (BM) are commonly diagnosed in dogs. Their pathogenesis remains incompletely understood, and recent studies have questioned the clinical relevance of distinguishing BE and/or BM, suggesting that their pathogenic mechanisms may overlap and that differentiating between them may have limited clinical significance. To date, the…
Open article record in new tab ↗Cannabidiol (CBD) is increasingly being used in veterinary medicine; however, its systemic molecular effects in dogs remain poorly characterized. This study employed label-free quantitative proteomics to compare the serum proteomic responses of healthy dogs (n = 18) after 30 days of oral CBD delivery via three distinct matrices: hemp by-product feed pellets (F), CBD-infused oil (O), and semi-solid treat (SN). The…
Open article record in new tab ↗Introduction The study of hemp-based cannabinoids has focused primarily on cannabidiol (CBD). Cannabis sativa however, naturally synthesizes cannabidiolic acid (CBDA) as opposed to the better-known neutral derivative. The precursor to cannabidiolic CBDA is cannabigerolic acid (CBGA) and cultivar extracts that contain both acidic cannabinoids are available as animal supplements. Pharmacokinetically these acidic can…
Open article record in new tab ↗Activated charcoal (AC) is a convenient, effective method for gastrointestinal decontamination, typically supplied as either activated charcoal powder (pAC) or proprietary mixtures in granules or suspension (e.g., Toxiban®, Tox). We compared the adsorptive capacity for common veterinary toxicants of a new resin-bound activated charcoal product (Ready Rescue™; RR) to PAC and Tox. We hypothesized that RR is equivale…
Open article record in new tab ↗Introduction There is limited data on how veterinarians implement multimodal therapies for managing canine osteoarthritis (OA). The primary aim of this study was to describe how OA is managed by veterinarians with diverse backgrounds. The secondary aim was to report perceived side effects associated with bedinvetmab (LibrelaTM) and grapiprant. The authors hypothesized that variation exists in management patterns a…
Open article record in new tab ↗The resilience of biofilms makes it challenging to treat bacterial infections using conventional antibiotics. The study aimed to assess the antibacterial, anti-biofilm, anti-quorum-sensing, and cytotoxic activities of acetone extracts of Cannabis "Gorilla Glue 1" against fish pathogens. Antibacterial activity was determined using the two-fold serial microdilution method, while anti-biofilm activity was assessed us…
Open article record in new tab ↗Introduction In recent years, there has been an increase in access to and interest in cannabidiol (CBD) and hemp products, including use in companion dog supplements. Methods Using survey data from the Dog Aging Project (DAP), we characterized how human decisions around administering CBD and hemp products are informed by owner and dog demographics, the legal status of medical cannabis in their state, and the dog's…
Open article record in new tab ↗Introduction This study investigated the pharmacokinetics, safety, and tolerability of a full-spectrum CBD-dominant oil formulated in medium-chain triglycerides (MCT oil) after a single intravenous (IV) administration, a single oral (PO) administration, and multiple oral administrations of CBD at a dose of 2.2 mg/kg in adult male and female beagle dogs. Methods The CBD-dominant extract was administered to adult, i…
Open article record in new tab ↗This study evaluates the impact of dietary supplementation with hemp-based polyunsaturated fatty acids (PUFAs) on the membrane lipid profiles and reproductive performance of Martina Franca jacks. Over a 90-day period, twelve donkeys were divided into a treatment group receiving hemp oil and a control group on a standard diet. Semen and blood samples were collected and analyzed at multiple time points for lipid com…
Introduction Cannabis intoxication is increasingly reported in small animal practice, often resulting from accidental ingestion of human products or unsupervised access to the plant. Although clinical signs are well documented, laboratory alterations remain poorly described. This study aimed to confirm cannabis intoxication in dogs using a rapid urinary test for THC metabolites and to investigate associated hemato…
Introduction Cannabidiol (CBD) has shown potential therapeutic benefits in veterinary medicine, but further investigations are needed to establish its pharmacokinetics and therapeutic dosing in horses and ponies. The present study aimed to investigate the pharmacokinetic properties of CBD in Connemara ponies following oral administration of CBD oil. Methods Ten healthy ponies received a single oral dose of CBD oil…
Open article record in new tab ↗Background Cannabidiol (CBD) has anti-nociceptive and anti-inflammatory characteristics, and was reported to provide analgesia in dogs with osteoarthritis. However, oral CBD has poor bioavailability due to significant first-pass hepatic metabolism. Encapsulation of CBD into liposomes was reported by our group to facilitate CBD slow-release, and provide high bioavailability and analgesia in a pilot study in dogs wi…
A Maltese dog was presented with a stiff gait, secondary to muscle hypertonicity, affecting the axial and proximal appendicular muscles, which had progressively worsened over the last 4 years, associated with episodes of muscle spasms. Neuroanatomical localization was upper motor neuron (UMN) or generalized neuromuscular system. Cerebrospinal fluid (CSF) analysis was normal. Magnetic resonance imaging (MRI) of the…
Open article record in new tab ↗Introduction Cannabigerol (CBG) is a non-psychoactive cannabinoid with growing interest in veterinary medicine; however, its pharmacokinetic profile in horses remains unknown. Understanding its absorption, distribution, metabolism, and elimination is essential to optimizing dosing strategies and evaluating its potential for clinical use in equine patients. Methods A prospective crossover study was conducted in eig…
Introduction Demand for stress-reducing products aimed at pets has risen in recent years, demonstrated by an ever-growing market of nutritional and odor-based products. Previous research has demonstrated an effect of Cannabidiol (CBD), L-tryptophan and α-casozepine on stress-related behaviours in a variety of animal species, including dogs. The objective of this study was to explore the efficacy of a treat product…
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