Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
24 articles
Newest firstBackground The duration of untreated psychosis (DUP) is still considerably long in patients with psychotic disorders worldwide. Social determinants, such as the socioeconomic status, can influence DUP, exacerbating health inequalities in access to timely care. We investigated whether subpopulations with shared characteristics are associated with longer DUP. Methods We performed latent class analyses to investigate…
Open article record in new tab ↗Background Positive expectancies of cannabis use effects, which are the beliefs about the anticipated positive effects of cannabis, are robust cognitive precursors of adolescent cannabis initiation and escalation. However, little is known about how sociodemographic, familial, and psychopathological factors predict positive expectancies of cannabis use effects or how these expectancies evolve across early adolescen…
Introduction Driving under the influence of drugs is a major risk factor for road traffic collisions. While increasing harms are observed in relation to polydrug use, evidence is needed about this issue in the context of road safety. We examined polydrug use patterns in drivers providing samples for toxicological analysis in Ireland between 2019 and 2020. Methods A cross-sectional study using LC-MS toxicology resu…
BACKGROUND: Academic burnout is a major concern in higher education. We aimed to identify lifestyle groups among students using latent class analyses and to examine how sociodemographic characteristics and these lifestyle groups were associated with academic burnout. METHODS: A representative population-based survey of Finnish higher education students (n = 3639; aged 18–34 y) was conducted in 2024. Latent class a…
Open article record in new tab ↗Background: War-related stressors can disrupt core beliefs and shape trauma outcomes, yet the distinct roles of moral processes in post-traumatic outcomes remain insufficiently understood.Objective: To examine how war-related stressors (WRS) and core-belief disruption (CBD) relate to posttraumatic stress disorder (PTSD) symptoms, moral injury (MI), moral sensitivity (MS), posttraumatic growth (PTG), and posttrauma…
Background Adolescence is a key developmental period associated with an increased risk of experiencing cannabis-related problems. Identifying modifiable risk factors prior to the onset of cannabis use could help inform preventative interventions. Method Analysis nested within a UK prospective birth cohort study, the Avon Longitudinal Study of Parents and Children. Participants (n = 6,049) provided data on cannabis…
Open article record in new tab ↗Background Childhood trauma is a well-established risk factor for psychosis, paranoia, and substance use, with cannabis being a modifiable environmental factor that exacerbates these vulnerabilities. This study examines the interplay between childhood trauma, cannabis use, and paranoia using standard tetrahydrocannabinol (THC) units as a comprehensive measure of cannabis exposure. Methods Data were derived from th…
The availability of cannabis has increased due to expanding legalization of cannabis across the USA. Controlled use of cannabis - rules by cannabis users that limit use - is a significant but understudied area in the present policy environment, particularly among young adults. A prospective Los Angeles-based cohort aged 18-26 who used cannabis in the past 90 days was assessed during eight survey waves across 9 yea…
Open article record in new tab ↗Adolescent substance use can have a significant negative impact on life trajectories. Therefore, identifying factors associated with adolescent substance use is important. Previous research has identified parental religiosity as a factor associated with lower adolescent substance use. However, these studies suffered from a number of limitations and are often focussed on US samples, which limit the generalisability…
Open article record in new tab ↗Introduction Residential clients frequently report high psychological distress at intake, but little is known about changes in distress throughout treatment. This study aimed to identify in-treatment trajectories for psychological distress and factors associated with trajectory classes. Methods A retrospective cohort of adults attending Australian non-government residential substance use treatment between 2012 and…
Background Since the early 2000s, there have been marked trends in adolescent health and wellbeing indicators across Europe, North America and Australia. In particular, there have been substantial declines in youth drinking. We know little about how these trends are underpinned by co-occurring indicators within individuals. This paper aims to analyse change over time in how indicators cluster within individuals an…
Genetic contributions to human cortical structure manifest pervasive pleiotropy. This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. We investigated genetic pleiotropy by applying genomic structural equation modeling (SEM) to map the genetic architecture o…
We investigated associations between polysubstance use and behavioral problems among adolescents. Because substance use becomes more developmentally normative with age, we examined whether polysubstance use was less likely to co-occur with behavioral problems among older (vs. younger) adolescents. Using data from a nationally representative survey of US high school students, we compared the association between pol…
Open article record in new tab ↗Drug use, mental distress, and other psychosocial factors threaten HIV care for youth living with HIV (YLWH). We aimed to identify syndemic psychosocial patterns among YLWH and examine how such patterns shape HIV outcomes. Using baseline data from 208 YLWH enrolled in an HIV treatment adherence intervention, we performed latent class analysis on dichotomized responses to 9 psychosocial indicators (enacted HIV stig…
BackgroundIllicit substance use has constantly evolved over the years, particularly in the party scene. Monitoring these changes is essential to adapt harm reduction strategies. The OCTOPUS survey was implemented to enhance knowledge on drug use at music festivals. The objective of the work presented here was to describe drug use and to characterize profiles of substance use in music festival attendees.MethodsOCTO…
Open article record in new tab ↗Introduction The shifting landscape in Australia's tobacco and cannabis policies and emerging new products and modes of administration may increase experimentation and the risks of addiction to these drugs. Methods We analysed cross-sectional data from the 2019 National Drug Strategy and Household Survey (n = 22,015) of Australians aged 14 and above. Latent class analysis was used to identify distinct groups based…
Open article record in new tab ↗BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by a highly variable clinical presentation and multifaceted genetic and biological bases that translate into great patient heterogeneity. The identification of homogeneous subgroups of patients in terms of both clinical presentation and biological causes, could favour the development of effective treatments, healthcare…
Open article record in new tab ↗Background:Polysubstance use among people who misuse opioids (PWMO) is highly prevalent, but understudied. We defined, estimated, and analyzed national polysubstance use patterns among PWMO using National Household Survey on Drug Use and Health data (2017–2019).Methods:We obtained estimates of past-month patterns of polydrug use using cluster analysis and latent class/profile analysis. We considered misuse of pres…
Open article record in new tab ↗Substance Use Disorders (SUDs) pose significant challenges to both individuals and society at large. The primary focus of existing research with clinical SUD populations has been on individual substances, but research is required to better understand the profiles of individuals who use different substances simultaneously. The purpose of the current study was, therefore, to identify patterns of use among subjects (…
Open article record in new tab ↗Benzodiazepines (BZDs) represent one of the most widely used groups of pharmaceuticals, but if used for long periods of time they are associated with dependence and an increased risk of harmful effects. High-dose (HD) BZD dependence is a specific substance use disorder associated with a poor quality of life. It is especially important to pinpoint differences in HD BZD addict subgroups in order to tailor treatment…
Open article record in new tab ↗