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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
132 articles
Newest firstCannabinoid-based therapies have shown analgesic, anti-inflammatory, and wound-healing potential across veterinary species; however, clinical data on long-term use of THC-rich formulations in horses remain scarce. This case report describes the use of combined oral and topical THC-rich and CBD-rich full-spectrum cannabis oils as part of a palliative care strategy in a rescued horse with severe chronic disease. A s…
Open article record in new tab ↗Inflammation contributes to the rapid progression of high-grade gliomas, indicating that anti-inflammatory strategies targeting NF-κB signaling may offer therapeutic benefit. Cannabidiol (CBD) and celecoxib (CELE) are hydrophobic pharmacological agents whose formulation in lipid carriers may support their combined biological evaluation. In this proof-of-concept study, we investigated liposomal formulations contain…
CD16+ monocytes are a minor subset of the total monocyte population that play a disproportionate role in contributing to neuroinflammation in human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND). This has been evidenced by the enhanced transmigration of CD16+ monocytes into the brain compared to their CD16− counterpart. CD16+ monocytes can be activated by HIV ssRNAs through toll-like recep…
Open article record in new tab ↗Δ9-tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, and other drug molecules that have large molar masses, are often described as 'nonvolatile' and are presumed to be carried in exhaled breath aerosols. Large variabilities in THC concentrations in breath have been measured with devices that only collect aerosols; it is possible that neglecting the vapor phase could be responsible. Partitioni…
Cannabis sativa yields a wide range of bioactive compounds, including terpenes, flavonoids, and cannabinoids. Tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), and cannabichromenic acid (CBCA) are the acidic biosynthetic precursors of the neutral cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which have been the subject of much research. This review exami…
Open article record in new tab ↗BackgroundCannabidiol (CBD) has attracted renewed scientific attention for its therapeutic potential in human metabolism. However, the metabolic effects of CBD treatment remain incompletely understood.MethodsThis study investigated tissue-specific metabolic alterations in the brain, liver, and kidneys of Kramnik mice after 2 weeks of daily CBD treatment using an untargeted proton magnetic resonance (1H-NMR) metabo…
Open article record in new tab ↗Cannabidiol (CBD) has gained increasing attention as an ingredient in dietary supplements and functional foods due to its potential health-promoting properties. As a major non-psychoactive phytocannabinoid derived from Cannabis sativa L., CBD has been associated with anti-inflammatory, antioxidant, and neuroprotective effects. However, its application in nutraceutical products remains challenging because of its lo…
Open article record in new tab ↗BACKGROUND: Cannabidiol (CBD), main non-psychoactive ingredient of Cannabis sativa L. is known to have anti-ischemic, antidiabetic and neuroprotective effects. Ischemia–reperfusion injury of the retina is reportedly involved in deterioration of its function in diabetic retinopathy. The study was aimed to evaluate the in vivo potential retinoprotective role of CBD in type II diabetes mellitus. METHODS: Zucker Diabe…
Background: Solid pro-nano lipid (SPNL) oral formulations were prepared and tested in rats for enhanced oral bioavailability of cannabidiol (CBD). Methods: The solid formulation at room temperature is a uniform solution of CBD in a mixture of solid lipids and surfactants. Upon contact with aqueous media, it disperses into <200 nm particles. Up to 40% w/w of CBD can be loaded in this formulation into a hard gelatin…
Cannabidiol (CBD) is increasingly being used in veterinary medicine; however, its systemic molecular effects in dogs remain poorly characterized. This study employed label-free quantitative proteomics to compare the serum proteomic responses of healthy dogs (n = 18) after 30 days of oral CBD delivery via three distinct matrices: hemp by-product feed pellets (F), CBD-infused oil (O), and semi-solid treat (SN). The…
Open article record in new tab ↗Background/Objectives: Alzheimer's disease (AD) is a neurodegenerative disease for which there are no highly effective treatments, which highlights the need for novel therapeutics. Cannabidiol (CBD) has demonstrated antioxidant, anti-inflammatory and neuroprotective properties. Chronic CBD treatment (20 mg/kg and 50 mg/kg) reverses social recognition memory deficits of APPSwe/PS1∆E9 (APP/PS1) transgenic mice; howe…
Open article record in new tab ↗BACKGROUND: A variety of health benefits have been claimed, but not scientifically confirmed, for cannabidiol (CBD) and other nonintoxicating cannabinoids in hemp extracts such as cannabichromene (CBC), cannabigerol (CBG), and cannabinol (CBN). On the other hand, CBD has been reported to cause hepatotoxicity in clinical trials and research studies, while little is known about the safety of other cannabinoids. In t…
Medical cannabis use is steadily increasing worldwide, including among pregnant and breastfeeding women. This Perspective provides an overview of current evidence regarding cannabis exposure during pregnancy and lactation and its implications for clinical decision-making. The available literature indicates relatively consistent evidence linking prenatal Δ9-tetrahydrocannabinol (THC) exposure with adverse perinatal…
Open article record in new tab ↗Hemp (Cannabis sativa L.) is a multipurpose crop with significant industrial and therapeutic potential. This article reviews the various uses of hemp in production, building, food, cosmetics and medicine, focusing on its economic, environmental and health benefits. Industrially, hemp has been used for making fabrics, paper, bioplastics, construction materials and biofuels, because of its strong fibres, fast growth…
Open article record in new tab ↗Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to alterations in liver lipid metabolism, oxidative stress, fibrosis, and dysregulation of the endocannabinoid system (ECS). Although increasing evidence supports a role for cannabinoids in metabolic disorders, most preclinical studies have been conducted in male models, leaving female-specific responses largely unexplo…
Open article record in new tab ↗BACKGROUND: Exercise and sports-related musculoskeletal injuries often result in pain, and the recovery process can be prolonged and challenging. Many physically-active Americans have begun using cannabidiol (CBD) for pain relief and improved recovery time, and CBD is of particular interest due to its positive safety profile, non-intoxicating effects, and therapeutic potential. Our objectives were threefold. First…
Open article record in new tab ↗Insomnia is increasingly recognized as a manifestation of multisystem dysregulation characterized by sustained physiological hyperarousal. This review situates insomnia within a framework of reciprocal disturbances across neuroendocrine, inflammatory, and autonomic pathways. It examines the potential roles of cannabidiol (CBD), polyunsaturated fatty acids (PUFAs) derived from hemp seed oil (HSO), and lignans from…
Open article record in new tab ↗Background: Low-THC Cannabis sativa L. extracts are commonly believed to offer potential alternatives to non-steroidal anti-inflammatory drugs (NSAIDs) for inflammatory pain management. This study evaluated the anti-inflammatory effects of two C. sativa extracts (Tygra, Dora) and pure cannabidiol (CBD) compared with acetylsalicylic acid (ASA) in a carrageenan-induced rat paw inflammation model. Materials and Metho…
Epilepsy is a progressive network disorder in which recurrent seizures drive maladaptive neurodevelopmental remodeling, cognitive decline, and pharmacoresistance, particularly in developmental epileptic encephalopathies. Cannabidiol (CBD) has emerged as an evidence-based adjunctive therapy for selected childhood-onset epilepsies; however, its broader clinical utility remains limited by heterogeneous responsiveness…