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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
70 articles
Newest firstIntroduction Intracerebral hemorrhage (ICH) is a severe neurological disease with high mortality and disability, profoundly affecting patients' neurological function, daily activities, and quality of life. This study aimed to characterize the serum metabolic profile of patients with ICH and identify potential metabolic biomarkers associated with disease pathogenesis. Methods Liquid chromatography-mass spectrometry…
Open article record in new tab ↗The recent introduction of High-Efficacy Therapies (HETs) in clinical practice has drastically reduced the frequency of acute inflammatory episodes and relapses, in patients with Multiple Sclerosis (MS), gradually shifting the interest of clinicians toward preventing disease progression and treating symptoms associated with the residual disease. This article summarizes the output of a recent meeting (June 2025, in…
Background An elevated risk of cardiovascular disease (CVD) and cerebrovascular disease (CBD) has been observed in patients with ICD-defined Neuromyelitis Optica (hereinafter referred to as NMO). However, population-based research on this topic remains limited. In this study, the risk of macrovascular events was compared between individuals with NMO and a matched population without NMO in Taiwan. Methods Data for…
Open article record in new tab ↗[This corrects the article DOI: 10.3389/fneur.2026.1747131.].
Open article record in new tab ↗Background Pharmacoresistance to conventional antiseizure medications has been described in approximately 30% of the pediatric epileptic patients, making pharmacological management particularly challenging for physicians. Currently, cannabidiol (CBD) is approved as an adjunctive therapy in combination with clobazam for Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS), and as adjunctive treatment for Tuberous Sc…
Open article record in new tab ↗Introduction The diagnosis of corticobasal syndrome (CBS) is challenging due to its clinical overlap with other neurodegenerative disorders. Ideomotor apraxia is a core feature of CBS and often presents asymmetrically, but is often under-recognized in the clinical setting. Methods The "Paper-Toss Test" (PTT) is administered to a video-based case series of four patients with different CBS pathologies (Alzheimer's d…
Open article record in new tab ↗Neurocutaneous syndromes are a group of genetic disorders involving the nervous and cutaneous systems, including Tuberous Sclerosis Complex (TSC), neurofibromatosis type 1 (NF1), and Sturge-Weber syndrome (SWS), and others. The incidence of epilepsy, a core clinical manifestation, is significantly higher than in the general population. The purpose of this narrative review is to provide an updated overview of the g…
Open article record in new tab ↗Introduction Spasticity-Plus Syndrome (SPS) in multiple sclerosis (MS) represents a cluster of symptoms including spasticity, neuropathic pain, spasms, and bladder dysfunction. These manifestations may worsen after trauma or surgery. Pulsed radiofrequency (PRF) offers a minimally invasive neuromodulation strategy that could complement standard treatments. Methods We report the case of a 56-year-old woman with seco…
Open article record in new tab ↗Background As cannabis is increasingly used as a treatment option for epilepsy, people with epilepsy (PWE) may be at higher risk of developing cannabis use disorder (CUD). This study aimed to estimate the prevalence of CUD among privately insured PWE in the United States using IQVIA's 2022 PharMetrics® Plus for Academics health plan claims database. Methods A cross-sectional analysis was conducted using 2022 IQVIA…
Open article record in new tab ↗Objective Although peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce. This study quantified serum concentrations of four major endocannabinoids-anandamide (AEA), 2-arachidonoylglycerol (2-AG), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA)-in treatment-naïve Han Chinese children wi…
Background The occurrence of stroke in young people has risen significantly. This can easily lead to physical disabilities, swallowing difficulties, and cognitive impairment, among other issues, having a profound impact on families and society. Risk factors for stroke in young people differ from those for traditional stroke, with cannabis abuse emerging as a significant high-risk factor. However, the extent of the…
Open article record in new tab ↗Aim To evaluate the comparative efficacy and safety of various doses of oral cannabidiol (CBD) in treating refractory epilepsy indications, thus providing more informative evidence for clinical decision-making. Methods A literature search of PubMed, Embase, the Cochrane library, and Web of Science (WoS) was performed to retrieve relevant randomized controlled trials (RCTs) that compared different doses of oral CBD…
Open article record in new tab ↗Sturge-Weber syndrome (SWS) is a rare congenital neurovascular disorder that initially presents with a facial port-wine birthmark (PWB) and most commonly associated with a R183Q somatic mosaic mutation in the gene GNAQ. This mutation is enriched in endothelial cells. Contrast-enhanced magnetic resonance imaging (MRI) diagnoses brain abnormalities including leptomeningeal vascular malformation, an enlarged choroid…
Open article record in new tab ↗Background While emerging evidence supports a link between traumatic brain injury (TBI) and progressive cognitive dysfunction in Veterans, there is insufficient information on the impact of cannabis use disorder (CUD) on long-term cognitive disorders. This study aimed to examine the incidences of cognitive disorders in Veterans with TBI and CUD and to evaluate their relationship. Methods This retrospective cohort…
Open article record in new tab ↗Background Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system. More than 90,000 Canadians are affected; a cure is yet to be found. Available treatments to manage the disease course are only partially effective. For many years, persons with MS (PwMS) have used cannabis to relax, to reduce pain and spasticity, or to improve sleep and daily functioning, despite the lack…
Introduction Spasticity is a common symptom in multiple sclerosis (MS) and it is often associated with other symptoms such as spasms/cramps and pain. The concept of Spasticity-Plus syndrome takes into account that spasticity is accompanied by one or more symptoms (spasms/cramps, pain, bladder dysfunction, sleep disorders, fatigue and/or tremor). As these symptoms share a common cannabinoid control, therapy acting…
Open article record in new tab ↗Object This cross-sectional study aims to investigate migraineurs' preferred complementary and alternative medicine (CAM) types and the factors influencing their usage. Materials and methods An anonymous e-survey was distributed to Lithuanian Migraine Association members, and social media migraine support communities. The collected data consisted of demographic, migraine-related questions, personal qualities, CAM…
Open article record in new tab ↗Background While cannabis-based medicine is being commonly used in patients with movement disorders, there is a scarcity of publications regarding the effect of cannabis on dystonia. We aimed to describe medical cannabis use in patients with dystonia and related pain. Methods We employed a structured interview to obtain data on the cannabis treatment regimen, perception of effectiveness and side effect profile. El…
Open article record in new tab ↗Background Studies have demonstrated that individuals diagnosed with traumatic brain injury (TBI) frequently use medical and recreational cannabis to treat persistent symptoms of TBI, such as chronic pain and sleep disturbances, which can lead to cannabis use disorder (CUD). We aimed to determine the Veterans Health Administration (VHA) healthcare utilization and costs associated with CUD and dementia diagnosis in…