Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
715 articles
Newest firstObjective The objective of this study was to examine whether cannabis exposure calls to the British Columbia Drug and Poison Information Centre (DPIC) were impacted by the legalization of non-medical cannabis in Canada. Methods We fit interrupted time series models to monthly counts of cannabis cases from 2013 to 2021, stratified by age and cannabis form. We set the intervention month to October 2018 legalization…
Open article record in new tab ↗This study examined the prevalence and patterns of polydrug use among a national sample of civilians aged 12 years or older, with a focus on polydrug use involving opioids, assessing the influence of the first drug used on these behaviors. Using 2020 National Survey on Drug Use and Health (NSDUH) data, five mutually exclusive drug groups were identified in a hierarchical order: opioid use, stimulant or psychoactiv…
Purpose This study used data from the National Health and Nutrition Examination Survey (NHANES) to examine associations between the use of four illicit drugs (cocaine, heroin, marijuana, and methamphetamine) and the dental caries experience among adults in the US using the Decayed, Missing and Filled Teeth (DMFT) index. Materials and methods Data from NHANES 2017-2018, a cross-sectional study that included adults…
Dyadic coping among sexual minority men (SMM) has been a focus of HIV prevention research for decades, but few studies have examined relationship quality as a covariate of HIV care cascade outcomes (ART adherence and an undetectable viral load (VL)). This study utilized a 5-category relationship status variable (single; non-monogamous, sero-discordant; non-monogamous, sero-concordant; monogamous, sero-discordant;…
Open article record in new tab ↗Objective To evaluate trends in CHS hospitalizations in Canada, including their frequency and individual characteristics. Methods This study utilized data from the Canadian Institute for Health Information's Discharge Abstract Database to perform descriptive data analysis and employed JoinPoint Trend Analysis Software to analyze annual percent change (APC) and average annual percent change (AAPC) in hospitalizatio…
Open article record in new tab ↗Pain is prevalent among people with HIV (PWH), and many PWH who experience pain also use substances (illicit drug and/or unhealthy alcohol use). While cocaine use and cocaine and alcohol co-use are prevalent in this population, their effects on pain in PWH are unknown. This study aims to investigate the association of cocaine use and co-use of cocaine and alcohol with pain interference among PWH. We completed a se…
Open article record in new tab ↗Background Predicting progression from substance use to substance use disorder (SUD) is challenging, particularly for participants with cannabis and stimulant use who follow distinct risk trajectories. Machine learning enables integration of demographic, behavioral, wearable-derived, and social determinants of health (SDoH) data, yet few studies have compared linear and non-linear approaches in large, diverse popu…
Open article record in new tab ↗INTRODUCTION: Preoperative substance use is increasingly observed among candidates for metabolic and bariatric surgery (MBS), yet its perioperative and 1-year effects remain unclear in the Middle East and North Africa (MENA). We assessed whether routine preoperative urine toxicology screening tests (TSTs) predict anesthetic requirements, recovery, early complications, and 1-year weight loss. METHODS: Prospective s…
Comorbid substance use disorders (SUDs) are common but difficult to study due to the complex, interacting and overlapping mechanisms through which they affect brain networks. Many datasets collected to investigate a specific SUD include participants with comorbid SUDs. Although most studies treat comorbid SUDs as covariates of no interest, these covariates also contain untapped information. This is particularly re…
Open article record in new tab ↗PURPOSE: Cannabis use is increasing among older adults. Given reported associations between delta-9-tetrahydrocannabinol (THC) and increased acute heart rate, there is concern regarding the impact of cannabis on cardiovascular health in older adults. Engaging in regular physical activity (PA) is associated with reduced heart rate and cardiovascular disease risk, but it has yet to be explored whether PA status infl…
Open article record in new tab ↗Background: Several factors influence reasons for cannabis use in the U.S. This study examines reasons for cannabis use (recreational only, medical only, both) and their frequency of use in association with demographic variables, health-risk behaviors, legal status, and chronic disease. Methods: We performed a cross-sectional analysis of 466,355 adults (aged ≥18) in the 2018-2021 BRFSS surveys in areas that admini…
Open article record in new tab ↗Rationale Negative affect is a key factor in Alcohol Use Disorder (AUD) associated with craving and relapse risk that is insufficiently treated by approved medications. Cannabidiol (CBD) has shown promising effects on negative affect, indicating its potential for addressing the neurocircuitry underlying negative affect in AUD. Objectives This study investigates CBD's effects on neural response to negative emotiona…
Open article record in new tab ↗Background The objective of this study was to assess the prevalence of dependence and abuse of psychoactive substances (PAS) among prison inmates, using data from the OPPIDUM program between 2013 and 2022. Methods OPPIDUM is an annual, cross-sectional national program, conducted among users consulting in specialised addiction centres. Prison inmates were questioned about their PAS use during the week preceding the…
Background The public health impact of new nicotine products will depend on their use by different population groups. We assessed the prevalence of nicotine pouch use among youth and adults in Great Britain (GB). Aims and methods Cross-sectional annual Action on Smoking and Health Smokefree GB Adult Surveys 2020-2024 (n: 12 247 to 13 266, 18+) and Action on Smoking and Health Smokefree GB Youth Survey 2024 (n = 28…
Open article record in new tab ↗Fibromyalgia is a chronic disorder characterised by widespread pain and other symptoms that substantially impact the quality of life. This double-blind, randomised, placebo-controlled trial primarily assessed feasibility (procedures and intervention adherence) and safety/tolerability of a 1:1 delta-9-tetrahydrocannabinol:cannabidiol (THC:CBD) cannabis oil (10 mg/mL each) in 24 adults with fibromyalgia, with second…
Purpose Glaucoma is a leading cause of irreversible blindness globally, primarily driven by elevated intraocular pressure (IOP). Still, some patients progress despite significant IOP lowering, potentially due to impaired ocular blood flow. This study aimed to evaluate the effects of dronabinol, a synthetic tetrahydrocannabinol derivative, on ocular blood flow in primary open-angle glaucoma (POAG) patients. Methods…
Background An estimated 5 to 8 million US children live with a parent who uses cannabis, and most cannabis users report smoking cannabis inside their homes, placing children at risk for cannabis secondhand smoke (cSHS) exposure. Indoor air quality (IAQ) monitoring provides real-time feedback on airborne pollutants and has shown promise in reducing in-home tobacco secondhand smoke exposure, suggesting its potential…
Importance The primary psychoactive compound in cannabis, ∆9-tetrahydrocannabinol (THC) induces intoxication and functional impairment, raising safety concerns in driving. The traditional impairment detection method, behavioral field sobriety tests (FSTs), are subject to bias. Objective To determine whether resting-state functional near-infrared spectroscopy (fNIRS) can detect THC-related impairment with greater a…
Rationale Traumatically injured individuals can develop chronic negative psychological sequelae. Improved understanding of contributing, peri-traumatic risk factors is essential to reduce the risk of these consequences. Previous studies have found that peri-traumatic, circulating endocannabinoid concentrations are positively associated with development of post-traumatic stress disorder (PTSD), chronic pain and dep…
BACKGROUND: Cannabis, the most consumed illicit drug globally, has been legal for non-medical use in Canada since 2018. Problematic internet use is considered a behavioral addiction involving excessive online activities (e.g., social media, video watching), which can cause social isolation, family issues, psychological distress, and even suicide ideation. Studies mainly conducted with adolescents indicate a link b…