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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
33 articles
Newest firstIntroduction Use of cannabis vaping products has been increasing in Canada. This study examined the prevalence and patterns of use of cannabis vaping products, including higher-risk use, by sex and age. Methods Data were from four cycles of the Canadian Cannabis Survey, an annual web-based survey of people aged ≥ 16 years in Canada. Past 12-month consumers of cannabis for non-medical purposes were analysed (n2020…
Open article record in new tab ↗Background and objectives Adolescent substance use is a critical public health concern with significant long-term consequences, yet research on disparities by sexual orientation remains limited. Despite the unique stressors faced by sexual minority youth-particularly bisexual individuals-that increase their risk for substance use, most studies investigate disparities among older adolescents and adults. Using recen…
Introduction The co-use of substances confers risks above single-product use and has significant public health implications. This study investigated trends in past 30-day co-use of nicotine/tobacco products with alcohol and cannabis in the US using Population Assessment of Tobacco and Health Study data from Waves 4-6 (December 2016-November 2021). Methods All wave 4-6 PATH participants age 15+ were included in ana…
Open article record in new tab ↗Background Stigma experienced by individuals with cannabis use disorder (CUD) has been identified as a significant impediment to their engagement with treatment programs. Therefore, this study aims to investigate the effect of sociodemographic factors and familiarity with cannabis on stigmatizing attributions towards adolescent and adult case vignettes of people affected by CUD. Method A quota sampling web survey…
Open article record in new tab ↗New psychoactive substances (NPS) are health-hazardous through unpredictable toxicity and effects and largely unknown epidemiology, motivating studies of the latter. Up to 138 NPS were retrospectively identified using liquid chromatography-high resolution mass spectrometry data from all 34 183 oral fluid drug samples collected in one Swedish health care region 2019-2020 representing 9468 psychiatric and addiction…
Background and aims Cannabis use among U.S. older adults has risen rapidly over the past two decades. This study examined the changes in and correlates of cannabis-involved substance use treatment admissions among this demographic. Methods Using the 2000-2021 concatenated Treatment Episode Data Set-Admissions (TEDS-A) age 50+ (N=5,593,004), we fitted joinpoint regression models to examine changes in the percent of…
Open article record in new tab ↗The cannabinoid receptor 1 (CB1R) in the hippocampus has been involved in impulsivity and alcohol consumption in adolescent rats. However, the role of CB1R in the cerebellum, despite that structure's exceptionally high CB1R density, remains unexplored. We therefore tested the hypothesis that cerebellar CB1R contributes to regulating impulsive behaviour, alcohol consumption and seeking. Male Wistar rats, adolescent…
Open article record in new tab ↗Purpose A model is proposed in which longitudinal changes in adolescents' dispositions increase age-related risk for the onset of substance use. Method Pooled surveys from 25 longitudinal studies were examined. Disposition was calculated from eight variables: use intentions; refusal intentions; attitudes; positive consequence beliefs; beliefs about negative consequences; descriptive peer normative beliefs; injunct…
Open article record in new tab ↗Background Cannabis is a commonly used psychoactive drug, but its cognitive effects remain unclear, particularly in older adults. This study examined associations between past and present cannabis use and cognitive function among dementia-free older adults. Methods Cross-sectional and longitudinal data were drawn from the UK Biobank, including adults aged ≥60 years. Cannabis use patterns were self-reported, and co…
Open article record in new tab ↗Adolescents and young adults are using synthetic cannabinoids at increasing rates, and the use of synthetic cannabinoids (SCs) carries significant medical and psychiatric risks. Although studies have been conducted to preliminarily explore the pharmacological effects of the fourth-generation synthetic cannabinoid 5F-EDMB-PICA (ethyl 2-(1-(5-fluoropentyl)-1 H-indole-3-carboxamido)-3,3-dimethylbutyrate), there is st…
With increasing substance misuse among older adults, we examined the question of whether older adults may be less likely to endorse certain DSM-5 criteria for alcohol and cannabis use disorders (AUD and CUD). We used the 2021-2023 National Surveys on Drug Use and Health (N = 17,494 for AUD and N = 12,264 for CUD) and descriptive statistics to compare the 65+ and under 65 age groups in their endorsements of 11 DSM-…
Open article record in new tab ↗Background Veteran Response to Dosage in Chiropractic Therapy (VERDICT) was a pragmatic randomized trial testing chiropractic dosage effects in 766 veterans with chronic low back pain (CLBP) of ≥ 3 months. This cross-sectional analysis compares baseline characteristics of younger (18-to-64 years) and older veterans (≥ 65 years). Methods Data were collected from February 22, 2021 to May 21, 2025 via electronic heal…
The endocannabinoid system is a critical brain signaling pathway that is dysregulated in various brain disorders, including Alzheimer's disease (AD). Cannabinoid-targeted therapies and imaging approaches have gained increasing interest; however, the biological impact of the endocannabinoid system in disease needs further validation. We aimed to study changes in cannabinoid receptor 1 (CB1) and monoacylglycerol lip…
Background Cannabinoid-based medicines (CBMs) are being used widely in older people. However, information on the incidence of adverse events (AEs) is limited. Objective To quantify the incidence rate difference (IRD) of AEs in middle aged and older adults of age ≥50 years receiving CBMs and also examine associations with weekly doses. Design Systematic review and meta-analysis. Data sources MEDLINE, PubMed, EMBASE…
Background/purpose We evaluated the minimally invasive surgery for congenital biliary dilatation (CBD) in adults and children and analyzed the surgical outcomes, especially in children aged <6 years. Methods Characteristics and surgical outcomes of patients with CBD who underwent minimally invasive surgery at our hospital between 2013 and 2023 were retrospectively reviewed. Results Overall, 129 patients (89 childr…
Introduction Psychological well-being (PWB) is an important component of positive mental health (PMH) and an asset for population health. This study examined correlates of PWB among community-dwelling adults (18+ years) in the 10 Canadian provinces. Methods Using data from the 2019 Canadian Community Health Survey Rapid Response on PMH, we conducted linear regression analyses with sociodemographic, mental health,…
Background To explore at what age youth start using tobacco and/or nicotine products, which product is used first, product initiation sequences, and whether some socio-demographic characteristics are associated with substance use initiation. Methods Data were collected from an online questionnaire disseminated through social media and professional partners, targeting youth aged 14-25 in French-speaking Switzerland…
Rationale Attentional bias to drug-related stimuli is hypothesised to contribute towards addiction. However, the acute effects of Δ9-tetrahydrocannabinol (THC) on attentional bias to cannabis cues, the differential response in adults and adolescents, and the moderating effect of cannabidiol (CBD) are unknown. Objectives Our study investigated (1) the acute effects of vaporised cannabis on attentional bias to canna…
Open article record in new tab ↗Background Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders, including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to assess the interaction between prenatal and lactation alcohol exposure (PLAE) and a high-fat diet (HFD) during childhood and…
Background During adolescence, neuronal circuits exhibit plasticity in response to physiological changes and to adapt to environmental events. Nigrostriatal dopaminergic pathways are in constant flux during development. Evidence suggests a relationship between early use of cannabinoids and psychiatric disorders characterized by altered dopaminergic systems, such as schizophrenia and addiction. However, the impact…