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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
113 articles
Newest firstTriple-negative breast cancer (TNBC) remains highly aggressive and refractory to conventional treatments, underscoring the need for novel combination strategies. Here, we employed 2D and 3D in vitro models, transcriptomic profiling, and in vivo xenograft studies to evaluate the anticancer efficacy of cannabinoids combined with the terpene β-caryophyllene (BC) in resistant TNBC models. Among the tested cannabinoids…
Open article record in new tab ↗BackgroundThe therapeutic potential of Cannabis sativa has attracted growing interest in oncology. Its diverse phytochemicals, including cannabinoids, flavonoids, and terpenes, interact with oncogenic signaling pathways and the endocannabinoid system influencing tumour progression and therapeutic responses.ObjectiveThis review critically evaluates the molecular mechanisms by which Cannabis sativa phytochemicals mo…
Open article record in new tab ↗Cannabis sativa is one of the oldest and most versatile plants with many facets ranging from intoxicant to medicine. Legalisation of medicinal cannabis leads to an increasing complexity of specific forensic questions to distinguish between recreational and medicinal use, for example, in context with participation in road traffic. Hence, there is a recent interest in finding objective markers that enable the differ…
Open article record in new tab ↗Three-dimensional (3D) printing has emerged as a versatile platform in pharmaceutical sciences, enabling fabrication of personalized dosage forms with controlled drug release and tailored properties using printable hydrogel bioinks. This study aimed to develop mucoadhesive hydrogel buccal films for cannabinoid delivery using extrusion-based 3D bioprinting. The films incorporated cannabidiol (CBD) and tetrahydrocan…
Open article record in new tab ↗Introduction Cannabis sativa L. roots are traditionally used to manage gastrointestinal (GI) disorders; however, experimental pharmacological evidence supporting these uses remains limited. This study investigated the chemical profile, safety, and GI-related pharmacological effects of an ethanolic extract of C. sativa roots (CEECs). Methods Chemical characterization was performed by spectrophotometric determinatio…
Cannabis sativa L. has a long history of medicinal and industrial use, with female flowers as the primary source of bioactive cannabinoids and terpenoids synthesized in glandular trichomes. Despite its importance, the genetic mechanisms governing flower development, sex determination, and secondary metabolite biosynthesis remain incompletely understood. Here, we combined transcriptomic and comparative genomic anal…
Open article record in new tab ↗Nine previously undescribed meroterpenoid glucosides, named nemophilosides A-I, were isolated from the whole plant extract of Nemophila menziesii. Their molecular structures were determined from their NMR and MS spectra, and the absolute configurations were confirmed using ECD spectroscopy by comparing the experimental data with calculated data. The meroterpenoids consist of monoterpenoids and hydroquinone moietie…
Simple SummaryThe pet food industry is increasingly looking for natural ingredients that can improve both the nutritional value and microbiological safety of dog diets while making better use of agricultural resources. Industrial hemp cultivation generates large amounts of leaves that are often underutilized, although they contain valuable natural compounds. This study compared hemp leaves and inflorescences from…
Chronic stress is increasingly recognized as a major contributor to systemic disease. Prolonged or repeated activation of the hypothalamic–pituitary–adrenal (HPA) axis and sympathoadrenal systems may contribute to glucocorticoid receptor resistance and chronic low-grade inflammation, although stress-related responses vary depending on stressor characteristics, population, age, sex, health status, and study design.…
Open article record in new tab ↗Background This review article addresses the vaping chemistry of manufactured cannabis concentrates-a topic that remains under-researched despite the widespread availability and growing popularity of these products. Given their current prevalence and the fact that many of the findings discussed herein are from early-stage investigations, further research is essential to fully assess the public health risks associa…
Open article record in new tab ↗Background Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder caused by oxidative stress and dysregulation of lipid metabolism. The endocannabinoid system (ECS), particularly the type 1 cannabinoid (CB1) receptor, plays a crucial role in NAFLD progression. Cannabinoids, such as cannabidiol (CBD) and tetrahydrocannabinol (THC), along with terpenes, such as beta-myrcene and d-limonene, have shown p…
Objective Cannabis sativa L. is renowned for its medicinal and recreational uses. With the increasing global legalization of C. sativa L.-based products for medicinal purposes, there is a growing need for well-characterized products. While the stability of cannabinoids such as tetrahydrocannabinol and cannabidiol is well understood, information on the chemical and enantiomeric stability of terpenes remains scarce.…
Open article record in new tab ↗Water availability is a key factor affecting both morphological development and secondary metabolite production in Cannabis sativa L. This study evaluated the effects of water stress applied during the vegetative and flowering stages on plant performance, cannabinoid concentration, and terpene composition in two Chemotype III (cannabidiol-dominant) varieties. Plants were subjected to moderate and severe water stre…
Open article record in new tab ↗Cannabis sativa L. exhibits a complex sensory profile governed by a diverse range of volatile and non-volatile compounds. Volatile constituents-such as terpenes, aldehydes, ketones, esters, and sulfur-containing compounds-together with non-volatile taste-active molecules including flavonoids and phenolic compounds, underlie its distinctive aroma and flavor. This review examines how genetic diversity, cultivation p…
Open article record in new tab ↗Trichomes in cannabis (Cannabis sativa L.) are specialized structures responsible for cannabinoid and terpene biosynthesis, making their density a critical parameter for both research and industrial applications. However, consistent trichome density assessment remains challenging due to anatomical variability and the absence of standardized methodologies. This review critically examines the existing literature on…
Open article record in new tab ↗Terpenoids are the largest and most diverse family of natural products. Volatile terpenes from Cannabis sativa are crucial in flavours, fragrances, and pharmaceuticals due to their unique odours and biological activities, including antimalarial, antibacterial, and insecticidal properties. Their synthesis is catalysed by terpene synthase (TPS) enzymes, which perform cyclisation and rearrangement reactions of over 5…
An efficient method for the simultaneous extraction of cannabinoids and terpenes from the leaves and flowers of Cannabis sativa L. (var. Felina 32) was developed. Extraction parameters, including solvent type, temperature, and pressure, were optimized, revealing that hexane enables high-yield cannabinoid recovery. Moreover, terpene composition was influenced by the extraction temperature. Two extracts with the hig…
Triatoma infestans is one of the primary vectors of Chagas disease. This vector has developed increasing resistance to pyrethroids, the main insecticides used for its control. Recent studies have highlighted the repellent and lethal effects of Cannabis sativa on insects, suggesting its potential use in pest management. Based on this, we hypothesize that C. sativa could be a viable bioactive for controlling T. infe…
This study compared the effects of storage time and electron beam (EB) irradiation on microbial counts and chemical stability of dried flowers from two hemp cultivars over 12 weeks. Cannabinoid and terpene content, as well as microbial load, were evaluated at 0, 4, 8, and 12 weeks in EB-irradiated and non-irradiated samples. Microbial count in non-irradiated flowers reached up to 4.1 × 106 colony-forming units (CF…
Open article record in new tab ↗Industrial hemp phytochemistry is shaped by genetics and agronomic management, yet field studies integrating both remain scarce. The combined effects of cultivar, planting density, fertilization, and flowering time on cannabinoids, terpenes, and antioxidants in Cannabis sativa L. were evaluated. A field trial was conducted in Mallorca (2023) using two cultivars (Enectaliana, Enectarol) grown at two densities (Sect…